Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density

• Published in: Journal of cosmetic dermatology Vol. 18; no. 6; pp. 1693 - 1699
• Main Authors: Maia Campos, Patricia M. B. G., Melo, Maisa Oliveira, Siqueira César, Francine Celise
• Format: Journal Article
• Language: English
• Published: England 01.12.2019
• Subjects: Administration, Cutaneous; Administration, Oral; Adult; biophysical and skin imaging techniques; dermocosmetic formulation; Dietary Supplements; Elasticity - drug effects; Female; Healthy Volunteers; Humans; hydrolyzed collagen; Middle Aged; oral supplementation; Peptides - administration & dosage; Photography; rice peptides; Skin - diagnostic imaging; Skin - drug effects; Skin - metabolism; Skin Aging - drug effects; Skin Care - methods; Ultrasonography; Viscosity - drug effects; rice peptides; dermocosmetic formulation; oral supplementation; hydrolyzed collagen; biophysical and skin imaging techniques
• ISSN: 1473-2130; 1473-2165; 1473-2165
• DOI: 10.1111/jocd.12893

Summary Background The combination of oral supplementation and topical formulations to the improvement of skin conditions has been proposed as an innovative approach to obtain effective treatments. However, studies comparing the effectiveness of each type of treatments are still in lack. This way, the objective of this work was to evaluate the clinical efficacy of a dermocosmetic formulation with di‐ and tripeptides, as well the effects of an oral supplementation based on hydrolyzed collagen through biophysical and skin imaging techniques. Methods Sixty healthy female subjects, aged between 40 and 50 years, were enrolled, being separated in 3 groups: topical formulation, oral supplementation, and oral placebo. The stratum corneum water content, skin viscoelasticity, dermis echogenicity, and skin pores parameters were evaluated. Results The group with the topical formulation showed a significant increase in the stratum corneum water content and skin elasticity after 28‐day period and also acted in the dermis echogenicity after 90 days with the formulation with peptides. The oral supplementation acted on skin elasticity and presented a more pronounced effect on dermis echogenicity, reducing skin pores after 90‐day period. Conclusion The obtained results with oral supplementation and topical application of hydrolyzed proteins were considered complementary in the improvement of general skin conditions, acting in different mechanisms.