Unveiling CYP450 inhibition by the pesticide prothioconazole through integrated in vitro studies and PBPK modeling - Perovani, Icaro S.; Yamamoto, Priscila A.; da Silva, Rodrigo M.; Lopes, Norberto P.; de Moraes, Natalia V.; de Oliveira, Anderson R. M. (Archives of toxicology, 2025)
Keywords: Adult; Animals; Area Under Curve; Balance studies; Biomedical and Life Sciences; Biomedicine; Computer Simulation; Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics; Cytochrome P-450 Enzyme Inhibitors - toxicity; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Cytochromes P450; Data processing; Drug dosages; Drug interaction; Drug Interactions; Environmental Health; Enzymes; Fungicides; Fungicides, Industrial - pharmacokinetics; Fungicides, Industrial - toxicity; Humans; Liver; Male; Mass balance; Metabolism; Metabolites; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Midazolam; Models, Biological; Nifedipine; Occupational Medicine/Industrial Medicine; Omeprazole; Pesticides; Pharmacokinetics; Pharmacology/Toxicology; Plasma; Rats; Rats, Sprague-Dawley; Risk assessment; Static models; Substrate inhibition; Tolbutamide; Toxicity; Toxicokinetics and Metabolism; Triazoles - administration & dosage; Triazoles - pharmacokinetics; Triazoles - toxicity; United States--US; Prothioconazole; Inhibition; CYP450; Risk assessment; Fungicide; PBPK modeling