Wettability and physicochemical characteristics of biphasic calcium phosphate mixtures depending on the ratio of hydroxyapatite and β-tricalcium phosphate

• Published in: Hanʼguk Seramik Hakhoe chi Vol. 60; no. 5; pp. 811 - 816
• Main Authors: Lee, Se Woong, Park, Okmin, Rho, Hyung Tay, Kim, Sang-il
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.09.2023
• Subjects: Ceramics; Chemistry and Materials Science; Composites; Glass; Materials Science; Natural Materials; Original Article; Wettability; Hydroxyapatite; Contact angle; tricalcium phosphate
• ISSN: 1229-7801; 2234-0491
• DOI: 10.1007/s43207-023-00304-6

Alloplastic grafts are synthetic, inorganic, biocompatible, and bioactive bone substitutes which promote osteoconduction, including hydroxyapatite (HA), β -tricalcium phosphate ( β -TCP), and biphasic calcium phosphate (BCP). A mixture of HA and β -TCP has been widely used as an alloplastic graft in dental applications, for its ability to modify the biodegradation rate by changing the HA/ β -TCP ratio. Wettability is widely known to be a significant and favorable factor for bone grafting materials as it allows immediate exposition to vascular invasion. Herein, a series of x HA-(100– x ) β -TCP ( x  = 0, 10, 30, 50, 70, 90, and 100 wt.%) samples were prepared and their wettability and physicochemical properties were examined. The chemical compositions and structural properties of the samples were studied using X-ray diffraction, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and energy dispersive X-ray spectroscopy. The pH of the samples in Dulbecco’s modified Eagle’s medium (DMEM) solvent increased from 7.55 to 8.55–9.28, implying the dissolution of the samples and Ca 2+ release. Contact angle of deionized water on the samples decreased gradually with increasing β -TCP content. HA exhibited low wetting while β -TCP exhibited complete wetting. Therefore, in terms of wettability, good osteogenic ability and workability for a bone grafting material can be achieved by including β -TCP.