Intestinal protective effects of essential oil from Chimonanthus salicifolius linked to Mfn2-tethered mitochondria-endoplasmic reticulum connection
[Display omitted] •41 compounds in Chimonanthus salicifolius essential oil (CSEO) identified by GC–MS.•CSEO protected intestinal epithelial cells from H2O2-induced oxidative stress.•Mfn2-tethered MAMs was implicated in the intestinal protection of CSEO.•Beneficial effects of CSEO linked to mitochond...
Saved in:
| Published in | Journal of functional foods Vol. 116; p. 106142 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
01.05.2024
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1756-4646 2214-9414 |
| DOI | 10.1016/j.jff.2024.106142 |
Cover
| Abstract | [Display omitted]
•41 compounds in Chimonanthus salicifolius essential oil (CSEO) identified by GC–MS.•CSEO protected intestinal epithelial cells from H2O2-induced oxidative stress.•Mfn2-tethered MAMs was implicated in the intestinal protection of CSEO.•Beneficial effects of CSEO linked to mitochondria-endoplasmic reticulum crosstalk.
Mitochondrial fusion protein 2 (Mfn2), a molecular tether for forming Mitochondria-associated membranes (MAMs), were dynamic platforms implicated in mitochondria-endoplasmic reticulum crosstalk. Here, 41 compounds were identified in Chimonanthus salicifolius essential oil (CSEO) by GC–MS, and its antioxidant capacities were demonstrated by free radical scavenging assays. Subsequently, cell viability results showed that treatment of intestinal epithelium-derived cell line (IEC-6 cells) with CSEO plus H2O2, considerably reduced oxidative damage, enhanced cell viability and antioxidant enzyme activities, when compared with those of treatment with H2O2 alone. Meanwhile, CSEO was demonstrated to reduce H2O2-caused apoptosis in parallel with enhancement of mitochondrial transmembrane potential, reduction of reactive oxygen species and calcium accumulation. Moreover, H2O2 significantly suppressed Mfn2 expression suggesting that intestinal impairment was involved in MAMs dysfunction. However, combination of H2O2 and CSEO significantly up-regulated Mfn2 protein. Together, CSEO exerted beneficial effects against intestinal injury by maintaining mitochondria-endoplasmic reticulum crosstalk through regulation of Mfn2. |
|---|---|
| AbstractList | Mitochondrial fusion protein 2 (Mfn2), a molecular tether for forming Mitochondria-associated membranes (MAMs), were dynamic platforms implicated in mitochondria-endoplasmic reticulum crosstalk. Here, 41 compounds were identified in Chimonanthus salicifolius essential oil (CSEO) by GC–MS, and its antioxidant capacities were demonstrated by free radical scavenging assays. Subsequently, cell viability results showed that treatment of intestinal epithelium-derived cell line (IEC-6 cells) with CSEO plus H₂O₂, considerably reduced oxidative damage, enhanced cell viability and antioxidant enzyme activities, when compared with those of treatment with H₂O₂ alone. Meanwhile, CSEO was demonstrated to reduce H₂O₂-caused apoptosis in parallel with enhancement of mitochondrial transmembrane potential, reduction of reactive oxygen species and calcium accumulation. Moreover, H₂O₂ significantly suppressed Mfn2 expression suggesting that intestinal impairment was involved in MAMs dysfunction. However, combination of H₂O₂ and CSEO significantly up-regulated Mfn2 protein. Together, CSEO exerted beneficial effects against intestinal injury by maintaining mitochondria-endoplasmic reticulum crosstalk through regulation of Mfn2. [Display omitted] •41 compounds in Chimonanthus salicifolius essential oil (CSEO) identified by GC–MS.•CSEO protected intestinal epithelial cells from H2O2-induced oxidative stress.•Mfn2-tethered MAMs was implicated in the intestinal protection of CSEO.•Beneficial effects of CSEO linked to mitochondria-endoplasmic reticulum crosstalk. Mitochondrial fusion protein 2 (Mfn2), a molecular tether for forming Mitochondria-associated membranes (MAMs), were dynamic platforms implicated in mitochondria-endoplasmic reticulum crosstalk. Here, 41 compounds were identified in Chimonanthus salicifolius essential oil (CSEO) by GC–MS, and its antioxidant capacities were demonstrated by free radical scavenging assays. Subsequently, cell viability results showed that treatment of intestinal epithelium-derived cell line (IEC-6 cells) with CSEO plus H2O2, considerably reduced oxidative damage, enhanced cell viability and antioxidant enzyme activities, when compared with those of treatment with H2O2 alone. Meanwhile, CSEO was demonstrated to reduce H2O2-caused apoptosis in parallel with enhancement of mitochondrial transmembrane potential, reduction of reactive oxygen species and calcium accumulation. Moreover, H2O2 significantly suppressed Mfn2 expression suggesting that intestinal impairment was involved in MAMs dysfunction. However, combination of H2O2 and CSEO significantly up-regulated Mfn2 protein. Together, CSEO exerted beneficial effects against intestinal injury by maintaining mitochondria-endoplasmic reticulum crosstalk through regulation of Mfn2. |
| ArticleNumber | 106142 |
| Author | Li, Yi-Jun Li, Wen-Juan Yang, Song-Yu Chen, Xuan-Ying Yang, Hua-Yu Chen, Sheng-Bin |
| Author_xml | – sequence: 1 givenname: Hua-Yu surname: Yang fullname: Yang, Hua-Yu organization: State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China – sequence: 2 givenname: Yi-Jun surname: Li fullname: Li, Yi-Jun organization: School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang 330031, China – sequence: 3 givenname: Xuan-Ying surname: Chen fullname: Chen, Xuan-Ying organization: The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China – sequence: 4 givenname: Song-Yu surname: Yang fullname: Yang, Song-Yu organization: The Fourth School of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330031, China – sequence: 5 givenname: Sheng-Bin surname: Chen fullname: Chen, Sheng-Bin organization: The Fourth School of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330031, China – sequence: 6 givenname: Wen-Juan surname: Li fullname: Li, Wen-Juan email: liwenjuan8211@126.com organization: State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China |
| BookMark | eNp9UbuOFDEQtNAhsXfwAWQOSWbxazxzIkIrOE46RAKx5bHb2l489mJ7TuI7-GG8WmKiflV1q7puyU3KCQh5y9meM67fn_anEPaCCdVrzZV4QXZCcDXcK65uyI5Pox6UVvoVua31xJjWXLId-fOYGtSGyUZ6LrmBa_gMFELoWaU5UKgVUsM-zxhpKHmlhyOuOdnUjlul1UZ0GHLEXkRMP8HTlunXkMTQoB2h9MaKLbtjTr6gHSD5fI62ruhogYZui9tKXU7pcj2n1-RlsLHCm3_xjvz4_On74cvw9O3h8fDxaXBSjG2QS1AzWDaxmQmhvXBh1IuUWk9aBjsGMS1LB7h75hYelB_l5P3M7Mw7BJS8I--ue7vwX1v_glmxOojRJshbNZKPUgut5dyh_Ap1JddaIJhzwdWW34YzczHAnEw3wFwMMFcDOufDlQNdwzNCMdUhJAceSxdqfMb_sP8CLNOT_w |
| Cites_doi | 10.1111/tpj.14874 10.3390/foods11162475 10.5582/bst.2022.01116 10.1016/j.fct.2021.112445 10.1007/978-3-030-42667-5_1 10.3390/app7030195 10.1016/j.burns.2021.11.009 10.3325/cmj.2020.61.126 10.1016/j.foodchem.2022.134906 10.1155/2019/7591840 10.3390/ijms20246338 10.1039/D2FO03310K 10.1021/acs.jafc.1c06812 10.1039/C9TB00594C 10.1016/j.foodchem.2022.132698 10.1021/acsami.1c18261 10.1016/j.jff.2022.105336 10.1016/j.cytogfr.2021.03.002 10.1590/fst.55720 10.1016/j.jff.2022.105087 10.1016/j.jff.2022.105127 10.1016/j.ymeth.2013.03.020 10.1016/j.fct.2020.111347 10.1039/D1FO04222J 10.1002/bmc.5322 10.3390/foods12051079 10.1016/j.jff.2020.103862 10.3390/foods11030464 10.1002/jsfa.8600 10.1016/j.fct.2022.112849 10.1155/2021/5527315 10.1002/jsfa.11941 |
| ContentType | Journal Article |
| Copyright | 2024 The Authors |
| Copyright_xml | – notice: 2024 The Authors |
| DBID | 6I. AAFTH AAYXX CITATION 7S9 L.6 |
| DOI | 10.1016/j.jff.2024.106142 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 2214-9414 |
| ExternalDocumentID | 10_1016_j_jff_2024_106142 S1756464624001440 |
| GroupedDBID | --K --M .~1 0R~ 0SF 1B1 1~. 4.4 457 4G. 5GY 5VS 6I. 7-5 71M 8P~ AABVA AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATLK AAXUO ABFNM ABGRD ABGSF ABJNI ABMAC ABXDB ACDAQ ACGFS ACNNM ACRLP ADBBV ADECG ADEZE ADMUD ADQTV ADUVX AEBSH AEHWI AEKER AENEX AEQOU AEXQZ AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJOXV AJSZI AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC EBS EFJIC EJD EP2 EP3 F5P FDB FEDTE FIRID FLBIZ FNPLU FYGXN GBLVA GROUPED_DOAJ HVGLF HZ~ J1W KOM M41 MO0 N9A NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 P2P PC. Q38 RIG ROL SDF SES SPC SSA SSK SSU SSZ T5K ~G- AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEIPS AEUPX AFJKZ AFPUW AGCQF AGRNS AIGII AIIUN AKBMS AKYEP ANKPU APXCP BNPGV CITATION SSH 7S9 L.6 |
| ID | FETCH-LOGICAL-c325t-3bf48ea07080226d2cf56b3366763fa5f27bb8eac90cb1f4d537dd80a81667e43 |
| IEDL.DBID | .~1 |
| ISSN | 1756-4646 |
| IngestDate | Fri Aug 22 20:38:17 EDT 2025 Tue Jul 01 03:10:59 EDT 2025 Sat May 25 15:41:20 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | DPPH EI CSEO DCF EM SOD Mitochondria-associated membranes Mitochondrial fusion protein MDA ER AsA IEC-6 cells BHT Intestinal protection BSA Chimonanthus salicifolius essential oil FBS Rho-123 MAMs Mfn2 ABTS Mitochondria-endoplasmic reticulum crosstalk |
| Language | English |
| License | This is an open access article under the CC BY-NC license. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c325t-3bf48ea07080226d2cf56b3366763fa5f27bb8eac90cb1f4d537dd80a81667e43 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S1756464624001440 |
| PQID | 3153626638 |
| PQPubID | 24069 |
| ParticipantIDs | proquest_miscellaneous_3153626638 crossref_primary_10_1016_j_jff_2024_106142 elsevier_sciencedirect_doi_10_1016_j_jff_2024_106142 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-05-01 |
| PublicationDateYYYYMMDD | 2024-05-01 |
| PublicationDate_xml | – month: 05 year: 2024 text: 2024-05-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Journal of functional foods |
| PublicationYear | 2024 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Tie, Xiang, Chen, Qiao, Cui, Su, Tan (b0125) 2022; 13 Christensen, Jansen, Sanchez, Waterhouse (b0030) 2013; 61 Angane, Swift, Huang, Butts, Quek (b0010) 2022; 11 Kim, Kim (b0055) 2021; 14 Wang, Fan, Hu, Sha, Zhang, Wang, Zhang, Wang, Zheng, Li (b0135) 2022; 94 An, Li, Zou, Wang, Zhang, Huang, Wang (b0015) 2023; 14 Chávez-Delgado, Jacobo-Velázquez (b0025) 2023; 12 Zhuang, Wu, Wang, He, He, Yin (b0160) 2019; 2019 Dhakad, Pandey, Beg, Rawat, Singh (b0035) 2018; 98 Boczek, Radzik, Ferenc, Zylinska (b0020) 2019; 20 Dong, Sun, Maker, Ren, Yu (b0040) 2022; 70 Alqahtani, Alqahtani, Al-Thabit, Roni, Syed (b0005) 2019; 7 Liao, Yang, Li, Zhou, Xiao, Yuan, Cha, He, Li (b0065) 2022; 93 Wen, Lei, Hou, Ke (b0140) 2021; 42 Mao, Zhang, Ji, Yun, Wei, Cui, Wang (b0090) 2022; 102 Fan, Wei, Wei, Zhang, Hou, Shen, Sun, Li, Wang, Jiao, Li (b0045) 2022; 99 Wan, Yao, Wu, Fu, Wu, Li (b0130) 2021; 156 Park, Lee, Jin, Park, Han, Jeong, Kwon, Kim, Park, Hong (b0100) 2022; 16 Rossi, Bohl, Braber, Ballatore, Escobar, Bodoira, Maestri, Porporatto, Cavaglieri, Montenegro (b0110) 2020; 67 Gao, Loveless, Shay, Teng (b0050) 2020; 1260 Liu, Liang, Jing, Yue, Xia, Yuan, Yue (b0070) 2022; 405 Yang, Li (b0150) 2022; 36 Yang, Li, Cheng, Fang, Mustafa, Pan, Xing, Lv, Zhang, Cheng (b0145) 2022; 385 Zhou, Ba, Wang, Gao, He, Yan, Wang, Shen (b0155) 2022; 48 Lv, Qiu, Liu, Li, Zhang, Wang, Fang, Pan, Chen, Cheng, Barker, Huang, Wei, Cheng, Huang (b0080) 2020; 103 Shi, Yu, Zhuang, Xi, He, Shao, Huang, Liu, Yang (b0115) 2021; 2021 Svaguša, Martinić, Martinić, Kovačević, Šepac, Miličić, Bulum, Starčević, Sirotković-Skerlev, Seiwerth (b0120) 2020; 61 Liu, Song (b0075) 2022; 161 Qian, Lin, Liu, Pan, Xie, Yang (b0105) 2022; 11 Malijauskaite, Connolly, Newport, McGourty (b0095) 2021; 60 Li, Wang, Kong, Yang, Luo, Yang (b0060) 2020; 141 Ma, Lv, Zhou, Fang, Cheng, Jiang, Cheng, Yao (b0085) 2017; 7 Yang (10.1016/j.jff.2024.106142_b0150) 2022; 36 Liu (10.1016/j.jff.2024.106142_b0075) 2022; 161 Ma (10.1016/j.jff.2024.106142_b0085) 2017; 7 Li (10.1016/j.jff.2024.106142_b0060) 2020; 141 Malijauskaite (10.1016/j.jff.2024.106142_b0095) 2021; 60 Boczek (10.1016/j.jff.2024.106142_b0020) 2019; 20 Wen (10.1016/j.jff.2024.106142_b0140) 2021; 42 Zhou (10.1016/j.jff.2024.106142_b0155) 2022; 48 Mao (10.1016/j.jff.2024.106142_b0090) 2022; 102 Liu (10.1016/j.jff.2024.106142_b0070) 2022; 405 Rossi (10.1016/j.jff.2024.106142_b0110) 2020; 67 Chávez-Delgado (10.1016/j.jff.2024.106142_b0025) 2023; 12 Angane (10.1016/j.jff.2024.106142_b0010) 2022; 11 Dhakad (10.1016/j.jff.2024.106142_b0035) 2018; 98 Wang (10.1016/j.jff.2024.106142_b0135) 2022; 94 Shi (10.1016/j.jff.2024.106142_b0115) 2021; 2021 Christensen (10.1016/j.jff.2024.106142_b0030) 2013; 61 Gao (10.1016/j.jff.2024.106142_b0050) 2020; 1260 Svaguša (10.1016/j.jff.2024.106142_b0120) 2020; 61 Kim (10.1016/j.jff.2024.106142_b0055) 2021; 14 Dong (10.1016/j.jff.2024.106142_b0040) 2022; 70 Wan (10.1016/j.jff.2024.106142_b0130) 2021; 156 Lv (10.1016/j.jff.2024.106142_b0080) 2020; 103 An (10.1016/j.jff.2024.106142_b0015) 2023; 14 Qian (10.1016/j.jff.2024.106142_b0105) 2022; 11 Fan (10.1016/j.jff.2024.106142_b0045) 2022; 99 Park (10.1016/j.jff.2024.106142_b0100) 2022; 16 Alqahtani (10.1016/j.jff.2024.106142_b0005) 2019; 7 Liao (10.1016/j.jff.2024.106142_b0065) 2022; 93 Yang (10.1016/j.jff.2024.106142_b0145) 2022; 385 Tie (10.1016/j.jff.2024.106142_b0125) 2022; 13 Zhuang (10.1016/j.jff.2024.106142_b0160) 2019; 2019 |
| References_xml | – volume: 14 start-page: 23002 year: 2021 end-page: 23021 ident: b0055 article-title: ROS-scavenging therapeutic hydrogels for modulation of the inflammatory response publication-title: ACS Applied Materials & Interfaces – volume: 94 start-page: 105127 year: 2022 end-page: 105135 ident: b0135 article-title: Maltol, a naturally occurring flavor enhancer, ameliorates cisplatin-induced apoptosis by inhibiting NLRP3 inflammasome activation by modulating ROS-mediated oxidative stress publication-title: Journal of Functional Foods – volume: 11 start-page: 464 year: 2022 end-page: 473 ident: b0010 article-title: Essential oils and their major components: An updated review on antimicrobial activities, mechanism of action, and their potential application in the food industry publication-title: Foods – volume: 16 start-page: 291 year: 2022 end-page: 300 ident: b0100 article-title: The preventive effect of loganin on oxidative stress-induced cellular damage in human keratinocyte HaCaT cells publication-title: BioScience Trends – volume: 103 start-page: 1910 year: 2020 end-page: 1923 ident: b0080 article-title: The Chimonanthus salicifolius genome provides insight into magnoliid evolution and flavonoid biosynthesis publication-title: The Plant Journal – volume: 7 start-page: 195 year: 2017 end-page: 203 ident: b0085 article-title: Identification of traditional she medicine Shi-Liang tea species and closely related species using the ITS2 Barcode publication-title: Applied Sciences – volume: 36 start-page: e5322 year: 2022 end-page: e5330 ident: b0150 article-title: Optimization of extraction process and the antioxidant activity spectrum–effect relationship of Angelica dahurica publication-title: Biomedical Chromatography – volume: 42 start-page: e55720 year: 2021 end-page: e55728 ident: b0140 article-title: Main components of ethyl acetate extract of Chimonanthus salicifolius and its effects on intestinal mucositis in mice induced by 5-fluorouracil publication-title: Food Science and Technology – volume: 12 start-page: 1079 year: 2023 end-page: 1088 ident: b0025 article-title: Essential oils: Recent advances on their dual role as food preservatives and Nutraceuticals against the metabolic syndrome publication-title: Foods – volume: 60 start-page: 76 year: 2021 end-page: 88 ident: b0095 article-title: Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms publication-title: Cytokine & Growth Factor Reviews – volume: 141 start-page: 111347 year: 2020 end-page: 111356 ident: b0060 article-title: Illicium verum essential oil, a potential natural fumigant in preservation of lotus seeds from fungal contamination publication-title: Food and Chemical Toxicology – volume: 99 start-page: 105336 year: 2022 end-page: 110545 ident: b0045 article-title: Platycodin D restores the intestinal mechanical Barrier by reducing endoplasmic reticulum stress-mediated apoptosis publication-title: Journal of Functional Foods – volume: 11 start-page: 2475 year: 2022 end-page: 2483 ident: b0105 article-title: In-vitro study on the antibacterial and antioxidant activity of four Commercial essential oils and in-situ evaluation of their effect on quality deterioration of Pacific white shrimp (Litopenaeus vannamei) during cold storage publication-title: Foods – volume: 98 start-page: 833 year: 2018 end-page: 848 ident: b0035 article-title: Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: A review publication-title: Journal of the Science of Food and Agriculture – volume: 13 start-page: 4023 year: 2022 end-page: 4031 ident: b0125 article-title: Facile synthesis of food-grade and size-controlled nanocarriers based on self-assembly of procyanidins and phycocyanin publication-title: Food & Function – volume: 102 start-page: 5903 year: 2022 end-page: 5912 ident: b0090 article-title: Leucine protects bovine intestinal epithelial cells from hydrogen peroxide-induced apoptosis by alleviating oxidative damage publication-title: Journal of the Science of Food and Agriculture – volume: 67 start-page: 103862 year: 2020 end-page: 103870 ident: b0110 article-title: Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells: Studies of cytotoxicity, cytoprotection, and interaction with ROS publication-title: Journal of Functional Foods – volume: 385 start-page: 132698 year: 2022 end-page: 1326106 ident: b0145 article-title: Proteomics and metabolomics reveal the mechanism underlying differential antioxidant activity among the organs of two base plants of Shiliang TEA (Chimonanthus salicifolius and Chimonanthus zhejiangensis) publication-title: Food Chemistry – volume: 1260 start-page: 1 year: 2020 end-page: 12 ident: b0050 article-title: Targeting ROS-mediated crosstalk between autophagy and apoptosis in cancer publication-title: Reviews on New Drug Targets in Age-Related Disorders – volume: 61 start-page: 138 year: 2013 end-page: 145 ident: b0030 article-title: Flow cytometry based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c release publication-title: Methods – volume: 2021 start-page: 5527315 year: 2021 end-page: 5527323 ident: b0115 article-title: Regulation of mitochondrial function by natural products for the treatment of metabolic associated fatty liver disease publication-title: Canadian Journal of Gastroenterology and Hepatology – volume: 93 start-page: 105087 year: 2022 end-page: 110596 ident: b0065 article-title: Anti-inflammatory effect of essential oil from Amomum Tsaoko Crevost et Lemarie publication-title: Journal of Functional Foods – volume: 48 start-page: 1213 year: 2022 end-page: 1220 ident: b0155 article-title: Combination of sodium butyrate and probiotics ameliorates severe burn-induced intestinal injury by inhibiting oxidative stress and inflammatory response publication-title: Burns – volume: 2019 start-page: 7591840 year: 2019 end-page: 7591849 ident: b0160 article-title: Resveratrol attenuates oxidative stress-induced intestinal Barrier injury through PI3K/Akt-mediated Nrf2 signaling pathway publication-title: Oxidative Medicine and Cellular Longevity – volume: 70 start-page: 3127 year: 2022 end-page: 3135 ident: b0040 article-title: Ozone treatment increases the release of VOC from Barley, which modifies seed germination publication-title: Journal of Agricultural and Food Chemistry – volume: 14 start-page: 2698 year: 2023 end-page: 2709 ident: b0015 article-title: Walnut polyphenols and the active metabolite urolithin a improve oxidative damage in SH-SY5Y cells by up-regulating PKA/CREB/BDNF signaling publication-title: Food & Function – volume: 156 start-page: 112445 year: 2021 end-page: 112453 ident: b0130 article-title: Chimonanthus nitens Oliv. essential oil mitigates lipopolysaccharide-induced acute lung injury in rats publication-title: Food and Chemical Toxicology – volume: 20 start-page: 6338 year: 2019 end-page: 6347 ident: b0020 article-title: The puzzling role of neuron-specific PMCA isoforms in the aging process publication-title: International Journal of Molecular Sciences – volume: 161 start-page: 112849 year: 2022 end-page: 112857 ident: b0075 article-title: Quercetin protects human liver cells from o, p’-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production publication-title: Food and Chemical Toxicology – volume: 405 start-page: 134906 year: 2022 end-page: 134914 ident: b0070 article-title: Preparation and characterization of publication-title: Food Chemistry – volume: 7 start-page: 4461 year: 2019 end-page: 4473 ident: b0005 article-title: Novel lignin nanoparticles for oral drug delivery publication-title: J – volume: 61 start-page: 126 year: 2020 end-page: 138 ident: b0120 article-title: Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart publication-title: Croatian Medical Journal – volume: 103 start-page: 1910 issue: 5 year: 2020 ident: 10.1016/j.jff.2024.106142_b0080 article-title: The Chimonanthus salicifolius genome provides insight into magnoliid evolution and flavonoid biosynthesis publication-title: The Plant Journal doi: 10.1111/tpj.14874 – volume: 11 start-page: 2475 year: 2022 ident: 10.1016/j.jff.2024.106142_b0105 article-title: In-vitro study on the antibacterial and antioxidant activity of four Commercial essential oils and in-situ evaluation of their effect on quality deterioration of Pacific white shrimp (Litopenaeus vannamei) during cold storage publication-title: Foods doi: 10.3390/foods11162475 – volume: 16 start-page: 291 year: 2022 ident: 10.1016/j.jff.2024.106142_b0100 article-title: The preventive effect of loganin on oxidative stress-induced cellular damage in human keratinocyte HaCaT cells publication-title: BioScience Trends doi: 10.5582/bst.2022.01116 – volume: 156 start-page: 112445 year: 2021 ident: 10.1016/j.jff.2024.106142_b0130 article-title: Chimonanthus nitens Oliv. essential oil mitigates lipopolysaccharide-induced acute lung injury in rats publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2021.112445 – volume: 1260 start-page: 1 year: 2020 ident: 10.1016/j.jff.2024.106142_b0050 article-title: Targeting ROS-mediated crosstalk between autophagy and apoptosis in cancer publication-title: Reviews on New Drug Targets in Age-Related Disorders doi: 10.1007/978-3-030-42667-5_1 – volume: 7 start-page: 195 issue: 3 year: 2017 ident: 10.1016/j.jff.2024.106142_b0085 article-title: Identification of traditional she medicine Shi-Liang tea species and closely related species using the ITS2 Barcode publication-title: Applied Sciences doi: 10.3390/app7030195 – volume: 48 start-page: 1213 year: 2022 ident: 10.1016/j.jff.2024.106142_b0155 article-title: Combination of sodium butyrate and probiotics ameliorates severe burn-induced intestinal injury by inhibiting oxidative stress and inflammatory response publication-title: Burns doi: 10.1016/j.burns.2021.11.009 – volume: 61 start-page: 126 year: 2020 ident: 10.1016/j.jff.2024.106142_b0120 article-title: Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart publication-title: Croatian Medical Journal doi: 10.3325/cmj.2020.61.126 – volume: 405 start-page: 134906 year: 2022 ident: 10.1016/j.jff.2024.106142_b0070 article-title: Preparation and characterization of Lycium Barbarum seed oil Pickering emulsions and evaluation of antioxidant activity publication-title: Food Chemistry doi: 10.1016/j.foodchem.2022.134906 – volume: 2019 start-page: 7591840 year: 2019 ident: 10.1016/j.jff.2024.106142_b0160 article-title: Resveratrol attenuates oxidative stress-induced intestinal Barrier injury through PI3K/Akt-mediated Nrf2 signaling pathway publication-title: Oxidative Medicine and Cellular Longevity doi: 10.1155/2019/7591840 – volume: 20 start-page: 6338 year: 2019 ident: 10.1016/j.jff.2024.106142_b0020 article-title: The puzzling role of neuron-specific PMCA isoforms in the aging process publication-title: International Journal of Molecular Sciences doi: 10.3390/ijms20246338 – volume: 14 start-page: 2698 year: 2023 ident: 10.1016/j.jff.2024.106142_b0015 article-title: Walnut polyphenols and the active metabolite urolithin a improve oxidative damage in SH-SY5Y cells by up-regulating PKA/CREB/BDNF signaling publication-title: Food & Function doi: 10.1039/D2FO03310K – volume: 70 start-page: 3127 year: 2022 ident: 10.1016/j.jff.2024.106142_b0040 article-title: Ozone treatment increases the release of VOC from Barley, which modifies seed germination publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/acs.jafc.1c06812 – volume: 7 start-page: 4461 year: 2019 ident: 10.1016/j.jff.2024.106142_b0005 article-title: Novel lignin nanoparticles for oral drug delivery publication-title: Journal of Materials Chemistry B doi: 10.1039/C9TB00594C – volume: 385 start-page: 132698 year: 2022 ident: 10.1016/j.jff.2024.106142_b0145 article-title: Proteomics and metabolomics reveal the mechanism underlying differential antioxidant activity among the organs of two base plants of Shiliang TEA (Chimonanthus salicifolius and Chimonanthus zhejiangensis) publication-title: Food Chemistry doi: 10.1016/j.foodchem.2022.132698 – volume: 14 start-page: 23002 year: 2021 ident: 10.1016/j.jff.2024.106142_b0055 article-title: ROS-scavenging therapeutic hydrogels for modulation of the inflammatory response publication-title: ACS Applied Materials & Interfaces doi: 10.1021/acsami.1c18261 – volume: 99 start-page: 105336 year: 2022 ident: 10.1016/j.jff.2024.106142_b0045 article-title: Platycodin D restores the intestinal mechanical Barrier by reducing endoplasmic reticulum stress-mediated apoptosis publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2022.105336 – volume: 60 start-page: 76 year: 2021 ident: 10.1016/j.jff.2024.106142_b0095 article-title: Gradients in the in vivo intestinal stem cell compartment and their in vitro recapitulation in mimetic platforms publication-title: Cytokine & Growth Factor Reviews doi: 10.1016/j.cytogfr.2021.03.002 – volume: 42 start-page: e55720 year: 2021 ident: 10.1016/j.jff.2024.106142_b0140 article-title: Main components of ethyl acetate extract of Chimonanthus salicifolius and its effects on intestinal mucositis in mice induced by 5-fluorouracil publication-title: Food Science and Technology doi: 10.1590/fst.55720 – volume: 93 start-page: 105087 year: 2022 ident: 10.1016/j.jff.2024.106142_b0065 article-title: Anti-inflammatory effect of essential oil from Amomum Tsaoko Crevost et Lemarie publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2022.105087 – volume: 94 start-page: 105127 year: 2022 ident: 10.1016/j.jff.2024.106142_b0135 article-title: Maltol, a naturally occurring flavor enhancer, ameliorates cisplatin-induced apoptosis by inhibiting NLRP3 inflammasome activation by modulating ROS-mediated oxidative stress publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2022.105127 – volume: 61 start-page: 138 year: 2013 ident: 10.1016/j.jff.2024.106142_b0030 article-title: Flow cytometry based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c release publication-title: Methods doi: 10.1016/j.ymeth.2013.03.020 – volume: 141 start-page: 111347 year: 2020 ident: 10.1016/j.jff.2024.106142_b0060 article-title: Illicium verum essential oil, a potential natural fumigant in preservation of lotus seeds from fungal contamination publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2020.111347 – volume: 13 start-page: 4023 year: 2022 ident: 10.1016/j.jff.2024.106142_b0125 article-title: Facile synthesis of food-grade and size-controlled nanocarriers based on self-assembly of procyanidins and phycocyanin publication-title: Food & Function doi: 10.1039/D1FO04222J – volume: 36 start-page: e5322 year: 2022 ident: 10.1016/j.jff.2024.106142_b0150 article-title: Optimization of extraction process and the antioxidant activity spectrum–effect relationship of Angelica dahurica publication-title: Biomedical Chromatography doi: 10.1002/bmc.5322 – volume: 12 start-page: 1079 year: 2023 ident: 10.1016/j.jff.2024.106142_b0025 article-title: Essential oils: Recent advances on their dual role as food preservatives and Nutraceuticals against the metabolic syndrome publication-title: Foods doi: 10.3390/foods12051079 – volume: 67 start-page: 103862 year: 2020 ident: 10.1016/j.jff.2024.106142_b0110 article-title: Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells: Studies of cytotoxicity, cytoprotection, and interaction with ROS publication-title: Journal of Functional Foods doi: 10.1016/j.jff.2020.103862 – volume: 11 start-page: 464 year: 2022 ident: 10.1016/j.jff.2024.106142_b0010 article-title: Essential oils and their major components: An updated review on antimicrobial activities, mechanism of action, and their potential application in the food industry publication-title: Foods doi: 10.3390/foods11030464 – volume: 98 start-page: 833 year: 2018 ident: 10.1016/j.jff.2024.106142_b0035 article-title: Biological, medicinal and toxicological significance of Eucalyptus leaf essential oil: A review publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.8600 – volume: 161 start-page: 112849 year: 2022 ident: 10.1016/j.jff.2024.106142_b0075 article-title: Quercetin protects human liver cells from o, p’-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2022.112849 – volume: 2021 start-page: 5527315 year: 2021 ident: 10.1016/j.jff.2024.106142_b0115 article-title: Regulation of mitochondrial function by natural products for the treatment of metabolic associated fatty liver disease publication-title: Canadian Journal of Gastroenterology and Hepatology doi: 10.1155/2021/5527315 – volume: 102 start-page: 5903 year: 2022 ident: 10.1016/j.jff.2024.106142_b0090 article-title: Leucine protects bovine intestinal epithelial cells from hydrogen peroxide-induced apoptosis by alleviating oxidative damage publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.11941 |
| SSID | ssj0066130 |
| Score | 2.3647602 |
| Snippet | [Display omitted]
•41 compounds in Chimonanthus salicifolius essential oil (CSEO) identified by GC–MS.•CSEO protected intestinal epithelial cells from... Mitochondrial fusion protein 2 (Mfn2), a molecular tether for forming Mitochondria-associated membranes (MAMs), were dynamic platforms implicated in... |
| SourceID | proquest crossref elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 106142 |
| SubjectTerms | antioxidant enzymes apoptosis calcium cell lines cell viability Chimonanthus Chimonanthus salicifolius essential oil essential oils free radicals Intestinal protection intestines membrane potential mitochondria Mitochondria-associated membranes Mitochondria-endoplasmic reticulum crosstalk Mitochondrial fusion protein reactive oxygen species reticulum |
| Title | Intestinal protective effects of essential oil from Chimonanthus salicifolius linked to Mfn2-tethered mitochondria-endoplasmic reticulum connection |
| URI | https://dx.doi.org/10.1016/j.jff.2024.106142 https://www.proquest.com/docview/3153626638 |
| Volume | 116 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ (Directory of Open Access Journals) customDbUrl: eissn: 2214-9414 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0066130 issn: 1756-4646 databaseCode: DOA dateStart: 20200101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 2214-9414 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0066130 issn: 1756-4646 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection 2013 customDbUrl: eissn: 2214-9414 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0066130 issn: 1756-4646 databaseCode: .~1 dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection Journals customDbUrl: eissn: 2214-9414 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0066130 issn: 1756-4646 databaseCode: AIKHN dateStart: 20200101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection Journals customDbUrl: eissn: 2214-9414 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0066130 issn: 1756-4646 databaseCode: ACRLP dateStart: 20200101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 2214-9414 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0066130 issn: 1756-4646 databaseCode: AKRWK dateStart: 20090101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhueRS2iSl6WNRoORQUHZrPew9LkvDNiW5JIHchJ7EYVdest5DL_0T_cOdke1AA82h-CQhGaORPo003zcm5LPHpFgl98w7KZlQJjATCseitJWd2Ko0UxQKX16pxa24uJN3O2Q-aGGQVtljf4fpGa37mnE_muN1XY-vYeNTAh5kQWKIEhXsQiGt7-zXE81DoX-cRZFSMWw9RDYzx-shYhbPQpzlg1Hxr73pGUrnref8NXnV-4x01n3WG7IT0gE5nCU4L69-0lOaWZz5evyQ_MYrPli22KHPwQB4RnvaBm0ixWThCdb1kjb1kqK8hM7vwWLIiLnfbugGPHNXx2ZZQwHju8HTtqGXMRWszfJgqFgBEABwJg_zl4XkmzV44ava0SyKxBtF6pBCk1UTR-T2_NvNfMH6Hy8wxwvZMm6jqIIBNEAhrvKFi1JZzpEPy6ORsSithQZuOnH2axRe8tL7amIwCFkGwd-S3dSk8I5QGHFeOeW8mzghTGVNGSU4pcZPhXImHJMvw5DrdZdfQw_EswcN9tFoH93Z55iIwSj6r0miAf9f6nYyGFDD4sGIiEmh2W40B7yHEx184vv_e_UHso-ljgH5key2j9vwCbyU1o7yNByRvdn3H4urUT7r_wGgEewu |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLZGd4ALYgzEgIGREAck0xL_SHqsKqaOrb2wSbtZ_qllap2Kpgf-Dv5h3nOSA5PgMOUUJ44sP_vzs9_3vRDy0WNSrJJ75p2UTCgTmAmFY1Hayk5sVZopCoWXK7W4Ft9v5M0BmQ9aGKRV9tjfYXpG675k3PfmeFvX4x-w8CkBF7IgMUT5iBwKCZg8Ioez84vFagBkhS5y1kVKxbDCENzMNK-7iIk8C_El742Kfy1P94A6rz5nz8jT3m2ks65lR-QgpOfkeJZgy7z5RT_RTOTMJ-TH5Dee8sHMxQp9GgaANNozN2gTKeYLTzC117Sp1xQVJnR-C0ZDUsztfkd34Jy7OjbrGm4wxBs8bRu6jKlgbVYIQ8EGsACwM3kYwiwk32zBEd_UjmZdJB4qUocsmiyceEGuz75dzRes__cCc7yQLeM2iioYAATU4ipfuCiV5RwpsTwaGYvSWnjBTSfOfo3CS156X00MxiHLIPhLMkpNCq8IhR7nlVPOu4kTwlTWlFGCX2r8VChnwgn5PHS53nYpNvTAPbvTYB-N9tGdfU6IGIyi_xonGpaA_1X7MBhQw_zBoIhJodnvNAfIh00dNPH1wz79njxeXC0v9eX56uINeYJPOkLkWzJqf-7DKTgtrX3XD8o_FbPt5A |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Intestinal+protective+effects+of+essential+oil+from+Chimonanthus+salicifolius+linked+to+Mfn2-tethered+mitochondria-endoplasmic+reticulum+connection&rft.jtitle=Journal+of+functional+foods&rft.au=Yang%2C+Hua-Yu&rft.au=Li%2C+Yi-Jun&rft.au=Chen%2C+Xuan-Ying&rft.au=Yang%2C+Song-Yu&rft.date=2024-05-01&rft.issn=1756-4646&rft.volume=116&rft.spage=106142&rft_id=info:doi/10.1016%2Fj.jff.2024.106142&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jff_2024_106142 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-4646&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-4646&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-4646&client=summon |