Anti-viral activity of blue chanterelle (Polyozellus multiplex) that inhibits α-glucosidase

• Published in: Food science and biotechnology Vol. 22; no. 3; pp. 747 - 750
• Main Authors: Lee, Doseung, Boo, Kyung Hwan, Lee, Jin-Man, Unno, Tatsuya, Lee, Wang Shik, Cho, Moonjae, Riu, Key Zung, Lee, Dong-Sun
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.06.2013; 한국식품과학회
• Subjects: Chemistry; Chemistry and Materials Science; Food Science; Nutrition; Research Note; 식품과학; α-glucosidase inhibitor; trafficking inhibitor
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-013-0140-7

Blue chanterelle ( Polyozellus multiplex ), known as an edible mushroom, was extracted using methanol to screen on anti-viral agent. Syncytium formation in Newcastle disease virus (NDV)-infected baby hamster kidney (BHK) cell originates from the trafficking of viral glycoprotein into cell-surface. Blue chanterelle inhibited not only syncytium formation, but also trafficking of glycoprotein, hemagglutinin-neuramidase (HN), onto cell-surface. Viral glycoprotein is processed within the endoplasmic reticulum during routing to surface. Blue chanterelle extracts showed the inhibitory activities (IC 50 10 μg/mL) against α-glucosidase. These results suggested that blue chanterelle extracts inhibited the cell-surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.