Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well-defined in the context...

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Bibliographic Details
Published in	Development (Cambridge) Vol. 143; no. 17; pp. 3050 - 3060
Main Authors	Yu, Jason S. L., Cui, Wei
Format	Journal Article
Language	English
Published	England 01.09.2016
Subjects	Animals Cell Proliferation - genetics Cell Proliferation - physiology Cell Survival - genetics Cell Survival - physiology Humans Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Pluripotent Stem Cells - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - genetics Signal Transduction - physiology TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism mTOR AKT Proliferation and differentiation PI3K Metabolism Pluripotency
Online Access	Get full text
ISSN	0950-1991 1477-9129
DOI	10.1242/dev.137075

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Abstract	Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well-defined in the context of tumorigenesis, recent studies – in particular those using pluripotent stem cells – have highlighted the importance of this pathway to development and cellular differentiation. Here, we review the recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR signalling plays in the control of pluripotency and differentiation, with a particular focus on the molecular mechanisms underlying these functions.
AbstractList	Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well-defined in the context of tumorigenesis, recent studies - in particular those using pluripotent stem cells - have highlighted the importance of this pathway to development and cellular differentiation. Here, we review the recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR signalling plays in the control of pluripotency and differentiation, with a particular focus on the molecular mechanisms underlying these functions. Summary: This Review highlights the important role of the PI3K/AKT/mTOR signalling pathway in stem cells and discusses its role in regulating important aspects of proliferation and differentiation. Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well-defined in the context of tumorigenesis, recent studies - in particular those using pluripotent stem cells - have highlighted the importance of this pathway to development and cellular differentiation. Here, we review the recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR signalling plays in the control of pluripotency and differentiation, with a particular focus on the molecular mechanisms underlying these functions.
Author	Cui, Wei Yu, Jason S. L.
Author_xml	– sequence: 1 givenname: Jason S. L. orcidid: 0000-0001-5203-3603 surname: Yu fullname: Yu, Jason S. L. organization: Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, Du Cane Road, London W12 0NN, UK – sequence: 2 givenname: Wei orcidid: 0000-0003-2019-380X surname: Cui fullname: Cui, Wei organization: Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, Du Cane Road, London W12 0NN, UK
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/27578176$$D View this record in MEDLINE/PubMed
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Snippet	Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the...
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SubjectTerms	Animals Cell Proliferation - genetics Cell Proliferation - physiology Cell Survival - genetics Cell Survival - physiology Humans Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Pluripotent Stem Cells - metabolism Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - genetics Signal Transduction - physiology TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
Title	Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
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