In-vitro drug release and stability assessment of tailored levan–chitosan biocomposite hydrogel

An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic...

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Published inIranian polymer journal Vol. 33; no. 1; pp. 11 - 23
Main Authors Veerapandian, Bhuvaneshwari, Selvaraj, Thirupathi Kumara Raja, Shanmugam, Saravanan Ramiah, Sarwareddy, Kartik Kumar, Mani, Krishna Priya, Venkatachalam, Ponnusami
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2024
Springer Nature B.V
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ISSN1026-1265
1735-5265
DOI10.1007/s13726-023-01229-x

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Abstract An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic properties with highly interconnected porous structures. The obtained OLC-gel exhibited better thermal stability compared to pristine levan. It was found that the OLC exhibited pH-dependent swelling behavior. The swelling ratio of OLC-gel at three different pH values indicates high hydrophilic nature in the order of pH 2.6 > pH 9.0 > pH 7.4. The hemolytic activity (3%) shown by the hydrogel was found to be within the clinical acceptance level (< 5%). OLC-gel loaded with turmeric oleoresin with 8.28% curcumin content showed a sustained release rate over 24 h. The kinetic release profile of the OLC-gel followed the Korsmeyer–Peppas model with non-Fickian release transport. The synthesized OLC-gel exhibited good cytocompatibility when tested against L929 fibroblast cells. The formed OLC-gel supported cell adhesion and proliferation of fibroblast cells which could support tissue regeneration at the wound site. The characteristics of OLC-gels suggested that OLC has excellent potential to serve as a wound dressing material. Graphical abstract
AbstractList An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic properties with highly interconnected porous structures. The obtained OLC-gel exhibited better thermal stability compared to pristine levan. It was found that the OLC exhibited pH-dependent swelling behavior. The swelling ratio of OLC-gel at three different pH values indicates high hydrophilic nature in the order of pH 2.6 > pH 9.0 > pH 7.4. The hemolytic activity (3%) shown by the hydrogel was found to be within the clinical acceptance level (< 5%). OLC-gel loaded with turmeric oleoresin with 8.28% curcumin content showed a sustained release rate over 24 h. The kinetic release profile of the OLC-gel followed the Korsmeyer–Peppas model with non-Fickian release transport. The synthesized OLC-gel exhibited good cytocompatibility when tested against L929 fibroblast cells. The formed OLC-gel supported cell adhesion and proliferation of fibroblast cells which could support tissue regeneration at the wound site. The characteristics of OLC-gels suggested that OLC has excellent potential to serve as a wound dressing material. Graphical abstract
An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic properties with highly interconnected porous structures. The obtained OLC-gel exhibited better thermal stability compared to pristine levan. It was found that the OLC exhibited pH-dependent swelling behavior. The swelling ratio of OLC-gel at three different pH values indicates high hydrophilic nature in the order of pH 2.6 > pH 9.0 > pH 7.4. The hemolytic activity (3%) shown by the hydrogel was found to be within the clinical acceptance level (< 5%). OLC-gel loaded with turmeric oleoresin with 8.28% curcumin content showed a sustained release rate over 24 h. The kinetic release profile of the OLC-gel followed the Korsmeyer–Peppas model with non-Fickian release transport. The synthesized OLC-gel exhibited good cytocompatibility when tested against L929 fibroblast cells. The formed OLC-gel supported cell adhesion and proliferation of fibroblast cells which could support tissue regeneration at the wound site. The characteristics of OLC-gels suggested that OLC has excellent potential to serve as a wound dressing material.
Author Shanmugam, Saravanan Ramiah
Veerapandian, Bhuvaneshwari
Sarwareddy, Kartik Kumar
Venkatachalam, Ponnusami
Mani, Krishna Priya
Selvaraj, Thirupathi Kumara Raja
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Keywords Wound dressing
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Snippet An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of...
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SubjectTerms Biocompatibility
Cell adhesion
Ceramics
Chemistry
Chemistry and Materials Science
Chitosan
Composite materials
Composites
Crosslinking
Fibroblasts
Glass
Hydrogels
Natural Materials
Oleoresins
Original Research
Oxidation
Polymer Sciences
Regeneration (physiology)
Stability analysis
Sustained release
Swelling ratio
Thermal stability
Tissue engineering
Wound healing
Title In-vitro drug release and stability assessment of tailored levan–chitosan biocomposite hydrogel
URI https://link.springer.com/article/10.1007/s13726-023-01229-x
https://www.proquest.com/docview/2909669451
Volume 33
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