In-vitro drug release and stability assessment of tailored levan–chitosan biocomposite hydrogel
An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic...
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Published in | Iranian polymer journal Vol. 33; no. 1; pp. 11 - 23 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.01.2024
Springer Nature B.V |
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Online Access | Get full text |
ISSN | 1026-1265 1735-5265 |
DOI | 10.1007/s13726-023-01229-x |
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Abstract | An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic properties with highly interconnected porous structures. The obtained OLC-gel exhibited better thermal stability compared to pristine levan. It was found that the OLC exhibited pH-dependent swelling behavior. The swelling ratio of OLC-gel at three different pH values indicates high hydrophilic nature in the order of pH 2.6 > pH 9.0 > pH 7.4. The hemolytic activity (3%) shown by the hydrogel was found to be within the clinical acceptance level (< 5%). OLC-gel loaded with turmeric oleoresin with 8.28% curcumin content showed a sustained release rate over 24 h. The kinetic release profile of the OLC-gel followed the Korsmeyer–Peppas model with non-Fickian release transport. The synthesized OLC-gel exhibited good cytocompatibility when tested against L929 fibroblast cells. The formed OLC-gel supported cell adhesion and proliferation of fibroblast cells which could support tissue regeneration at the wound site. The characteristics of OLC-gels suggested that OLC has excellent potential to serve as a wound dressing material.
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AbstractList | An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic properties with highly interconnected porous structures. The obtained OLC-gel exhibited better thermal stability compared to pristine levan. It was found that the OLC exhibited pH-dependent swelling behavior. The swelling ratio of OLC-gel at three different pH values indicates high hydrophilic nature in the order of pH 2.6 > pH 9.0 > pH 7.4. The hemolytic activity (3%) shown by the hydrogel was found to be within the clinical acceptance level (< 5%). OLC-gel loaded with turmeric oleoresin with 8.28% curcumin content showed a sustained release rate over 24 h. The kinetic release profile of the OLC-gel followed the Korsmeyer–Peppas model with non-Fickian release transport. The synthesized OLC-gel exhibited good cytocompatibility when tested against L929 fibroblast cells. The formed OLC-gel supported cell adhesion and proliferation of fibroblast cells which could support tissue regeneration at the wound site. The characteristics of OLC-gels suggested that OLC has excellent potential to serve as a wound dressing material.
Graphical abstract An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of levan and imine bond formation during cross-linking mechanism. The gelation time for OLC was less than 10 min and the gel exhibited viscoelastic properties with highly interconnected porous structures. The obtained OLC-gel exhibited better thermal stability compared to pristine levan. It was found that the OLC exhibited pH-dependent swelling behavior. The swelling ratio of OLC-gel at three different pH values indicates high hydrophilic nature in the order of pH 2.6 > pH 9.0 > pH 7.4. The hemolytic activity (3%) shown by the hydrogel was found to be within the clinical acceptance level (< 5%). OLC-gel loaded with turmeric oleoresin with 8.28% curcumin content showed a sustained release rate over 24 h. The kinetic release profile of the OLC-gel followed the Korsmeyer–Peppas model with non-Fickian release transport. The synthesized OLC-gel exhibited good cytocompatibility when tested against L929 fibroblast cells. The formed OLC-gel supported cell adhesion and proliferation of fibroblast cells which could support tissue regeneration at the wound site. The characteristics of OLC-gels suggested that OLC has excellent potential to serve as a wound dressing material. |
Author | Shanmugam, Saravanan Ramiah Veerapandian, Bhuvaneshwari Sarwareddy, Kartik Kumar Venkatachalam, Ponnusami Mani, Krishna Priya Selvaraj, Thirupathi Kumara Raja |
Author_xml | – sequence: 1 givenname: Bhuvaneshwari surname: Veerapandian fullname: Veerapandian, Bhuvaneshwari organization: Biomass Conversion and Bioproducts Laboratory, Center for Bioenergy, School of Chemical & Biotechnology, SASTRA Deemed University – sequence: 2 givenname: Thirupathi Kumara Raja surname: Selvaraj fullname: Selvaraj, Thirupathi Kumara Raja organization: Biomass Conversion and Bioproducts Laboratory, Center for Bioenergy, School of Chemical & Biotechnology, SASTRA Deemed University – sequence: 3 givenname: Saravanan Ramiah surname: Shanmugam fullname: Shanmugam, Saravanan Ramiah organization: Biomass Conversion and Bioproducts Laboratory, Center for Bioenergy, School of Chemical & Biotechnology, SASTRA Deemed University, Department of Biosystems Engineering, Auburn University – sequence: 4 givenname: Kartik Kumar surname: Sarwareddy fullname: Sarwareddy, Kartik Kumar organization: Cardiomyocyte Toxicity and Oncology Research Laboratory, School of Chemical & Biotechnology, SASTRA Deemed University – sequence: 5 givenname: Krishna Priya surname: Mani fullname: Mani, Krishna Priya organization: Cardiomyocyte Toxicity and Oncology Research Laboratory, School of Chemical & Biotechnology, SASTRA Deemed University – sequence: 6 givenname: Ponnusami orcidid: 0000-0002-0982-5354 surname: Venkatachalam fullname: Venkatachalam, Ponnusami email: vponnu@chem.sastra.edu organization: Biomass Conversion and Bioproducts Laboratory, Center for Bioenergy, School of Chemical & Biotechnology, SASTRA Deemed University |
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Snippet | An oxidized levan–chitosan (OLC) cross-linked hydrogel, a 3D network polymeric material, was prepared. Spectroscopic techniques confirmed the oxidation of... |
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SubjectTerms | Biocompatibility Cell adhesion Ceramics Chemistry Chemistry and Materials Science Chitosan Composite materials Composites Crosslinking Fibroblasts Glass Hydrogels Natural Materials Oleoresins Original Research Oxidation Polymer Sciences Regeneration (physiology) Stability analysis Sustained release Swelling ratio Thermal stability Tissue engineering Wound healing |
Title | In-vitro drug release and stability assessment of tailored levan–chitosan biocomposite hydrogel |
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