One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst

• Published in: Monatshefte für Chemie Vol. 154; no. 2; pp. 231 - 237
• Main Authors: El Hallaoui, Achraf, Merroun, Youssef, Chehab, Soukaina, Ghailane, Rachida, Souizi, Abdelaziz
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.02.2023; Springer Nature; Springer Nature B.V
• Subjects: Acetophenone; Aldehydes; Ammonium acetate; Analytical Chemistry; Aromatic compounds; Bimetals; Catalysis; Catalysts; Chemistry; Chemistry and Materials Science; Chemistry, Multidisciplinary; Chemistry/Food Science; Chemists; Heterocyclic compounds; Inorganic Chemistry; Organic Chemistry; Original Paper; Phosphates; Physical Chemistry; Physical Sciences; Pyridines; Science & Technology; Silver compounds; Theoretical and Computational Chemistry; Trisubstituted pyridines; Aza-heterocycles; Bimetallic catalyst; One-pot condensation; Al/Ag; PO; ACID; SOLVENT-FREE; EFFICIENT SYNTHESIS; DEGRADATION; PYRIDINES; Al/Ag3PO4
• ISSN: 0026-9247; 1434-4475
• DOI: 10.1007/s00706-022-03023-6

The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag 3 PO 4 phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines. Graphical abstract