Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation - Moore, Mary P.; Wang, Xiaobo; Kennelly, John Paul; Shi, Hongxue; Ishino, Yuki; Kano, Kuniyuki; Aoki, Junken; Cherubini, Alessandro; Ronzoni, Luisa; Guo, Xiuqing; Chalasani, Naga P.; Khalid, Shareef; et al. (Hepatology, 2025)
Keywords: Acyltransferases - genetics; Acyltransferases - metabolism; Adaptor Proteins, Signal Transducing; Animals; Disease Models, Animal; Genetic Predisposition to Disease; Hepatocytes - metabolism; Humans; Liver Cirrhosis - etiology; Liver Cirrhosis - genetics; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - genetics; Trans-Activators - metabolism; Transcriptional Coactivator with PDZ-Binding Motif Proteins; Up-Regulation