Structures of Nanodiamonds with Photoactive Modifiers

• Published in: Surface investigation, x-ray, synchrotron and neutron techniques Vol. 17; no. 1; pp. 7 - 16
• Main Authors: Lebedev, V. T., Kulvelis, Yu. V., Soroka, M. A., Kyzyma, O. A., Vul, A. Ya
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.02.2023; Springer Nature B.V
• Subjects: Aqueous solutions; Biomedical materials; Chemistry and Materials Science; Detonation; Diamonds; Electronegativity; Europium; Fullerenes; Heat treatment; Magnetic properties; Magnetic resonance imaging; Materials Science; Nanostructure; Neutron scattering; Photodynamic therapy; Photon correlation spectroscopy; Surfaces and Interfaces; Thin Films; diamond; scattering; neutron; complex; nanoparticle; biomedicine; diphthalocyanine; structure; fullerene; aggregate
• ISSN: 1027-4510; 1819-7094
• DOI: 10.1134/S1027451023010159

Binary and ternary complexes of europium fullerenes and diphthalocyanines with detonation nanodiamonds are obtained for the first time, which can serve as platforms for the delivery of these hydrophobic molecules into aqueous biological media for magnetic resonance imaging, photodynamic therapy, and diagnostics using luminescent labels. Detonation nanodiamonds (~4–5 nm in size) have a positive potential (30–70 mV) in an aqueous medium due to the groups (CH, COH) grafted to the surface by heat treatment in an atmosphere of hydrogen. When positively charged diamonds interact with electronegative hydrated fullerenes in an aqueous medium, the initial aggregates of each of the components are destroyed, and the electrostatic attraction between them leads to the formation of stable compact complexes ~20 nm in size, according to dynamic light scattering and neutron scattering in colloids (20°C). Binary complexes include, on average, two fullerene molecules per 30–40 diamond particles. Introducing diphthalocyanine molecules into a binary colloid yields stable ternary structures. The resulting complexes of diamonds, fullerenes, and diphthalocyanine molecules are promising for biomedical applications due to the luminescent and magnetic properties of the components.