A novel peptide derived from Haematococcus pluvialis residue exhibits anti-aging activity in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway
To explore the value of Haematococcus pluvialis ( H. pluvialis ) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel peptide (HPp) as a potential bioactive component. However, the possible anti-aging activity in vivo was not...
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| Published in | Food & function Vol. 14; no. 12; pp. 5576 - 5588 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
19.06.2023
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2042-6496 2042-650X 2042-650X |
| DOI | 10.1039/D3FO00383C |
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| Abstract | To explore the value of
Haematococcus pluvialis
(
H. pluvialis
) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel peptide (HPp) as a potential bioactive component. However, the possible anti-aging activity
in vivo
was not illuminated. In this study, the capacity of extending the lifespan and the mechanism based on
Caenorhabditis elegans
(
C. elegans
) were determined. The results showed that 100 μM HPp not only enhanced the lifespan of
C. elegans
in normal environments by 20.96% but also strengthened the lifespan in oxidative and thermal conditions effectively. Moreover, HPp succeeded in lessening the decline in physiological functions of aging worms. In terms of antioxidant efficacy, SOD and CAT enzyme activity were promoted, but the level of MDA was diminished significantly after HPp treatment. Subsequent analysis directly reflected the relationship between higher stress resistance and up-regulation of
skn-1
and
hsp-16.2
, and between greater antioxidant ability and up-regulation of
sod-3
and
ctl-2
. Further studies illustrated that HPp up-graded the mRNA transcription of the genes associated with the insulin/insulin-like growth factor signaling (IIS) pathway and some co-factors, including
daf-16
,
daf-2
,
ins-18
, and
sir-2.1
. Particularly, the activation of the IIS pathway required the regulation of subcellular localization of DAF-16/FOXO. Taken together, HPp could promote longevity with improved stress resistance and antioxidant properties
in vivo
through the IIS pathway. These data suggested that HPp might serve as a good source of anti-aging actives, and in particular, laid a foundation for the high value-added application of marine microalgae. |
|---|---|
| AbstractList | To explore the value of
(
) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel peptide (HPp) as a potential bioactive component. However, the possible anti-aging activity
was not illuminated. In this study, the capacity of extending the lifespan and the mechanism based on
(
) were determined. The results showed that 100 μM HPp not only enhanced the lifespan of
in normal environments by 20.96% but also strengthened the lifespan in oxidative and thermal conditions effectively. Moreover, HPp succeeded in lessening the decline in physiological functions of aging worms. In terms of antioxidant efficacy, SOD and CAT enzyme activity were promoted, but the level of MDA was diminished significantly after HPp treatment. Subsequent analysis directly reflected the relationship between higher stress resistance and up-regulation of
and
, and between greater antioxidant ability and up-regulation of
and
. Further studies illustrated that HPp up-graded the mRNA transcription of the genes associated with the insulin/insulin-like growth factor signaling (IIS) pathway and some co-factors, including
,
,
, and
. Particularly, the activation of the IIS pathway required the regulation of subcellular localization of DAF-16/FOXO. Taken together, HPp could promote longevity with improved stress resistance and antioxidant properties
through the IIS pathway. These data suggested that HPp might serve as a good source of anti-aging actives, and in particular, laid a foundation for the high value-added application of marine microalgae. To explore the value of Haematococcus pluvialis (H. pluvialis) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel peptide (HPp) as a potential bioactive component. However, the possible anti-aging activity in vivo was not illuminated. In this study, the capacity of extending the lifespan and the mechanism based on Caenorhabditis elegans (C. elegans) were determined. The results showed that 100 μM HPp not only enhanced the lifespan of C. elegans in normal environments by 20.96% but also strengthened the lifespan in oxidative and thermal conditions effectively. Moreover, HPp succeeded in lessening the decline in physiological functions of aging worms. In terms of antioxidant efficacy, SOD and CAT enzyme activity were promoted, but the level of MDA was diminished significantly after HPp treatment. Subsequent analysis directly reflected the relationship between higher stress resistance and up-regulation of skn-1 and hsp-16.2, and between greater antioxidant ability and up-regulation of sod-3 and ctl-2. Further studies illustrated that HPp up-graded the mRNA transcription of the genes associated with the insulin/insulin-like growth factor signaling (IIS) pathway and some co-factors, including daf-16, daf-2, ins-18, and sir-2.1. Particularly, the activation of the IIS pathway required the regulation of subcellular localization of DAF-16/FOXO. Taken together, HPp could promote longevity with improved stress resistance and antioxidant properties in vivo through the IIS pathway. These data suggested that HPp might serve as a good source of anti-aging actives, and in particular, laid a foundation for the high value-added application of marine microalgae.To explore the value of Haematococcus pluvialis (H. pluvialis) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel peptide (HPp) as a potential bioactive component. However, the possible anti-aging activity in vivo was not illuminated. In this study, the capacity of extending the lifespan and the mechanism based on Caenorhabditis elegans (C. elegans) were determined. The results showed that 100 μM HPp not only enhanced the lifespan of C. elegans in normal environments by 20.96% but also strengthened the lifespan in oxidative and thermal conditions effectively. Moreover, HPp succeeded in lessening the decline in physiological functions of aging worms. In terms of antioxidant efficacy, SOD and CAT enzyme activity were promoted, but the level of MDA was diminished significantly after HPp treatment. Subsequent analysis directly reflected the relationship between higher stress resistance and up-regulation of skn-1 and hsp-16.2, and between greater antioxidant ability and up-regulation of sod-3 and ctl-2. Further studies illustrated that HPp up-graded the mRNA transcription of the genes associated with the insulin/insulin-like growth factor signaling (IIS) pathway and some co-factors, including daf-16, daf-2, ins-18, and sir-2.1. Particularly, the activation of the IIS pathway required the regulation of subcellular localization of DAF-16/FOXO. Taken together, HPp could promote longevity with improved stress resistance and antioxidant properties in vivo through the IIS pathway. These data suggested that HPp might serve as a good source of anti-aging actives, and in particular, laid a foundation for the high value-added application of marine microalgae. To explore the value of Haematococcus pluvialis (H. pluvialis) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel peptide (HPp) as a potential bioactive component. However, the possible anti-aging activity in vivo was not illuminated. In this study, the capacity of extending the lifespan and the mechanism based on Caenorhabditis elegans (C. elegans) were determined. The results showed that 100 μM HPp not only enhanced the lifespan of C. elegans in normal environments by 20.96% but also strengthened the lifespan in oxidative and thermal conditions effectively. Moreover, HPp succeeded in lessening the decline in physiological functions of aging worms. In terms of antioxidant efficacy, SOD and CAT enzyme activity were promoted, but the level of MDA was diminished significantly after HPp treatment. Subsequent analysis directly reflected the relationship between higher stress resistance and up-regulation of skn-1 and hsp-16.2, and between greater antioxidant ability and up-regulation of sod-3 and ctl-2. Further studies illustrated that HPp up-graded the mRNA transcription of the genes associated with the insulin/insulin-like growth factor signaling (IIS) pathway and some co-factors, including daf-16, daf-2, ins-18, and sir-2.1. Particularly, the activation of the IIS pathway required the regulation of subcellular localization of DAF-16/FOXO. Taken together, HPp could promote longevity with improved stress resistance and antioxidant properties in vivo through the IIS pathway. These data suggested that HPp might serve as a good source of anti-aging actives, and in particular, laid a foundation for the high value-added application of marine microalgae. To explore the value of Haematococcus pluvialis ( H. pluvialis ) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel peptide (HPp) as a potential bioactive component. However, the possible anti-aging activity in vivo was not illuminated. In this study, the capacity of extending the lifespan and the mechanism based on Caenorhabditis elegans ( C. elegans ) were determined. The results showed that 100 μM HPp not only enhanced the lifespan of C. elegans in normal environments by 20.96% but also strengthened the lifespan in oxidative and thermal conditions effectively. Moreover, HPp succeeded in lessening the decline in physiological functions of aging worms. In terms of antioxidant efficacy, SOD and CAT enzyme activity were promoted, but the level of MDA was diminished significantly after HPp treatment. Subsequent analysis directly reflected the relationship between higher stress resistance and up-regulation of skn-1 and hsp-16.2 , and between greater antioxidant ability and up-regulation of sod-3 and ctl-2 . Further studies illustrated that HPp up-graded the mRNA transcription of the genes associated with the insulin/insulin-like growth factor signaling (IIS) pathway and some co-factors, including daf-16 , daf-2 , ins-18 , and sir-2.1 . Particularly, the activation of the IIS pathway required the regulation of subcellular localization of DAF-16/FOXO. Taken together, HPp could promote longevity with improved stress resistance and antioxidant properties in vivo through the IIS pathway. These data suggested that HPp might serve as a good source of anti-aging actives, and in particular, laid a foundation for the high value-added application of marine microalgae. |
| Author | Xie, Junting Xiao, Jie Chen, Xiaoyan He, Wanshi Cao, Yong Xia, Zenghui Liu, Xiaojuan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37232088$$D View this record in MEDLINE/PubMed |
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Haematococcus pluvialis
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H. pluvialis
) residue remaining after astaxanthin extraction and being discarded uneconomically, in our... To explore the value of ( ) residue remaining after astaxanthin extraction and being discarded uneconomically, in our previous study, we discovered a novel... To explore the value of Haematococcus pluvialis (H. pluvialis) residue remaining after astaxanthin extraction and being discarded uneconomically, in our... |
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| SubjectTerms | Aging Algae Antioxidants Astaxanthin Caenorhabditis elegans Chloramphenicol O-acetyltransferase Cytotoxicity Enzymatic activity Enzyme activity Forkhead protein Growth factors Haematococcus pluvialis In vivo methods and tests Insulin Insulin-like growth factor I Insulin-like growth factors Life span Localization Lymphocytes T Nematodes Peptides Residues Signal transduction Signaling |
| Title | A novel peptide derived from Haematococcus pluvialis residue exhibits anti-aging activity in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway |
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