Intra‐ and Peri‐tumoral Radiomics Based on Dynamic Contrast Enhanced ‐MRI to Identify Lymph Node Metastasis and Prognosis in Intrahepatic Cholangiocarcinoma

• Published in: Journal of magnetic resonance imaging Vol. 60; no. 6; pp. 2669 - 2680
• Main Authors: Pan, Yi‐Jun, Wu, Sun‐jie, Zeng, Yan, Cao, Zi‐Rui, Shan, Yan, Lin, Jiang, Xu, Peng‐Ju
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2024
• Subjects: Cholangiocarcinoma; Field strength; Image contrast; Image enhancement; Lymph nodes; Lymphatic system; Magnetic resonance imaging; Medical imaging; Medical prognosis; Metastases; Metastasis; Nomograms; Patients; Prognosis; Radiomics; Rank tests; Regression analysis; Regression models; Risk; Risk groups; Statistical analysis; Statistical tests; Survival; Training; radiomics; cholangiocarcinoma; prognosis; lymph node metastasis
• ISSN: 1053-1807; 1522-2586; 1522-2586
• DOI: 10.1002/jmri.29390

Lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (iCCA) affects treatment strategies and prognosis. However, preoperative imaging is not reliable enough for identifying LNM. To develop and validate a radiomics nomogram based on dynamic contrast enhanced (DCE)-MR images for identifying LNM and prognosis in iCCA. Retrospective. Two hundred four patients with pathologically proven iCCA who underwent curative-intent resection and lymphadenectomy (training cohort: N = 107, internal test cohort: N = 46, and external test cohort: N = 51). T1- and T2-weighted imaging, diffusion-weighted imaging and DCE imaging at 1.5 T or 3.0 T. Radiomics features were extracted from intra- and peri-tumoral regions on preoperative DCE-MR images. Imaging features were evaluated by three radiologists, and significant variables in univariable and multivariable regression analysis were included in clinical model. The best-performing radiomics signature and clinical characteristics (intrahepatic duct dilatation, MRI-reported LNM) were combined to build a nomogram. Patients were divided into high-risk and low-risk groups based on their nomogram scores (cutoff = 0.341). Patients were followed up for 1-102 months (median 12) after surgery, the overall survival (OS) and recurrence-free survival (RFS) were calculated. Receiver operating characteristic (ROC) curve, calibration, decision curve, Delong test, Kaplan-Meier curves, log rank test. Two tailed P < 0.05 was considered statistically significant. The nomogram incorporating intra- and peri-tumoral radiomics features, intrahepatic duct dilatation and MRI-reported LNM obtained the best discrimination for LNM, with areas under the ROC curves of 0.946, 0.913, and 0.859 in the training, internal, and external test cohorts. In the entire cohort, high-risk patients had significantly lower RFS and OS than low-risk patients. High-risk of LNM was an independent factor of unfavorable OS and RFS. The nomogram integrating intra- and peri-tumoral radiomics signatures has potential to identify LNM and prognosis in iCCA. 3 TECHNICAL EFFICACY: Stage 2.