Overcrowding Stress in Livestock Production Alters Gut Microbiota Composition and Neuronal Nitric Oxide Synthase (nNOS) Expression in nNOS-HiBiT Knock-in Mouse Model
Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitric oxide synthase (nNOS). This study aimed to investigate the effects of overcrowding str...
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| Published in | Food science of animal resources Vol. 45; no. 2; pp. 598 - 613 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Society for Food Science of Animal Resources
01.03.2025
한국축산식품학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2636-0772 2636-0780 2636-0780 |
| DOI | 10.5851/kosfa.2024.e117 |
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| Abstract | Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitric oxide synthase (nNOS). This study aimed to investigate the effects of overcrowding stress on the gut microbiota composition and nNOS expression. We generated an nNOS-HiBiT knock-in mouse model using the HiBiT system, a highly sensitive tool for accurately quantifying gene expression. Overcrowding stress was induced by housing twenty mice per cage (MPC20) and compared with a control group of two mice per cage (MPC2). Overcrowding stress increases nNOS levels in the hypothalamus and ileum and serum corticosterone levels. Gut microbial composition differed between the control and overcrowding stress-induced groups in the ileum, cecum, and colon. Specifically,
and
decreased in all three regions of MPC20, whereas
in the ileum and colon and
in the cecum increased in MPC20. Notably,
consistently decreased when nNOS and corticosterone expression were used as covariates under overcrowding stress. These regional variations reflect the differential impact of overcrowding stress on the intestinal tract, indicating complex interactions through nNOS expression within the brain-gut-microbiome axis. Importantly, the addition of probiotic feed, particularly those containing
, may counteract these decreases, leading to enhanced gut health and improved quality of livestock food products. This study enhances our understanding of the correlation between overcrowding stress and the gut microbiota, providing valuable data for improving the management environment in livestock farming. |
|---|---|
| AbstractList | Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitric oxide synthase (nNOS). This study aimed to investigate the effects of overcrowding stress on the gut microbiota composition and nNOS expression. We generated an nNOS-HiBiT knock-in mouse model using the HiBiT system, a highly sensitive tool for accurately quantifying gene expression. Overcrowding stress was induced by housing twenty mice per cage (MPC20) and compared with a control group of two mice per cage (MPC2). Overcrowding stress increases nNOS levels in the hypothalamus and ileum and serum corticosterone levels. Gut microbial composition differed between the control and overcrowding stress-induced groups in the ileum, cecum, and colon. Specifically,
and
decreased in all three regions of MPC20, whereas
in the ileum and colon and
in the cecum increased in MPC20. Notably,
consistently decreased when nNOS and corticosterone expression were used as covariates under overcrowding stress. These regional variations reflect the differential impact of overcrowding stress on the intestinal tract, indicating complex interactions through nNOS expression within the brain-gut-microbiome axis. Importantly, the addition of probiotic feed, particularly those containing
, may counteract these decreases, leading to enhanced gut health and improved quality of livestock food products. This study enhances our understanding of the correlation between overcrowding stress and the gut microbiota, providing valuable data for improving the management environment in livestock farming. Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitric oxide synthase (nNOS). This study aimed to investigate the effects of overcrowding stress on the gut microbiota composition and nNOS expression. We generated an nNOS-HiBiT knock-in mouse model using the HiBiT system, a highly sensitive tool for accurately quantifying gene expression. Overcrowding stress was induced by housing twenty mice per cage (MPC20) and compared with a control group of two mice per cage (MPC2). Overcrowding stress increases nNOS levels in the hypothalamus and ileum and serum corticosterone levels. Gut microbial composition differed between the control and overcrowding stress-induced groups in the ileum, cecum, and colon. Specifically, Bifidobacterium and Akkermansia decreased in all three regions of MPC20, whereas Helicobacter in the ileum and colon and Parasuterella in the cecum increased in MPC20. Notably, Bifidobacterium consistently decreased when nNOS and corticosterone expression were used as covariates under overcrowding stress. These regional variations reflect the differential impact of overcrowding stress on the intestinal tract, indicating complex interactions through nNOS expression within the brain-gut-microbiome axis. Importantly, the addition of probiotic feed, particularly those containing Bifidobacterium, may counteract these decreases, leading to enhanced gut health and improved quality of livestock food products. This study enhances our understanding of the correlation between overcrowding stress and the gut microbiota, providing valuable data for improving the management environment in livestock farming. KCI Citation Count: 0 Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitric oxide synthase (nNOS). This study aimed to investigate the effects of overcrowding stress on the gut microbiota composition and nNOS expression. We generated an nNOS-HiBiT knock-in mouse model using the HiBiT system, a highly sensitive tool for accurately quantifying gene expression. Overcrowding stress was induced by housing twenty mice per cage (MPC20) and compared with a control group of two mice per cage (MPC2). Overcrowding stress increases nNOS levels in the hypothalamus and ileum and serum corticosterone levels. Gut microbial composition differed between the control and overcrowding stress-induced groups in the ileum, cecum, and colon. Specifically, Bifidobacterium and Akkermansia decreased in all three regions of MPC20, whereas Helicobacter in the ileum and colon and Parasuterella in the cecum increased in MPC20. Notably, Bifidobacterium consistently decreased when nNOS and corticosterone expression were used as covariates under overcrowding stress. These regional variations reflect the differential impact of overcrowding stress on the intestinal tract, indicating complex interactions through nNOS expression within the brain-gut-microbiome axis. Importantly, the addition of probiotic feed, particularly those containing Bifidobacterium, may counteract these decreases, leading to enhanced gut health and improved quality of livestock food products. This study enhances our understanding of the correlation between overcrowding stress and the gut microbiota, providing valuable data for improving the management environment in livestock farming. Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitric oxide synthase (nNOS). This study aimed to investigate the effects of overcrowding stress on the gut microbiota composition and nNOS expression. We generated an nNOS-HiBiT knock-in mouse model using the HiBiT system, a highly sensitive tool for accurately quantifying gene expression. Overcrowding stress was induced by housing twenty mice per cage (MPC20) and compared with a control group of two mice per cage (MPC2). Overcrowding stress increases nNOS levels in the hypothalamus and ileum and serum corticosterone levels. Gut microbial composition differed between the control and overcrowding stress-induced groups in the ileum, cecum, and colon. Specifically, Bifidobacterium and Akkermansia decreased in all three regions of MPC20, whereas Helicobacter in the ileum and colon and Parasuterella in the cecum increased in MPC20. Notably, Bifidobacterium consistently decreased when nNOS and corticosterone expression were used as covariates under overcrowding stress. These regional variations reflect the differential impact of overcrowding stress on the intestinal tract, indicating complex interactions through nNOS expression within the brain-gut-microbiome axis. Importantly, the addition of probiotic feed, particularly those containing Bifidobacterium, may counteract these decreases, leading to enhanced gut health and improved quality of livestock food products. This study enhances our understanding of the correlation between overcrowding stress and the gut microbiota, providing valuable data for improving the management environment in livestock farming.Overcrowding stress in livestock farming is a significant concern for animal health and livestock products such as meats, milk, and eggs. It affects gut health by altering microbiota and regulating neuronal nitric oxide synthase (nNOS). This study aimed to investigate the effects of overcrowding stress on the gut microbiota composition and nNOS expression. We generated an nNOS-HiBiT knock-in mouse model using the HiBiT system, a highly sensitive tool for accurately quantifying gene expression. Overcrowding stress was induced by housing twenty mice per cage (MPC20) and compared with a control group of two mice per cage (MPC2). Overcrowding stress increases nNOS levels in the hypothalamus and ileum and serum corticosterone levels. Gut microbial composition differed between the control and overcrowding stress-induced groups in the ileum, cecum, and colon. Specifically, Bifidobacterium and Akkermansia decreased in all three regions of MPC20, whereas Helicobacter in the ileum and colon and Parasuterella in the cecum increased in MPC20. Notably, Bifidobacterium consistently decreased when nNOS and corticosterone expression were used as covariates under overcrowding stress. These regional variations reflect the differential impact of overcrowding stress on the intestinal tract, indicating complex interactions through nNOS expression within the brain-gut-microbiome axis. Importantly, the addition of probiotic feed, particularly those containing Bifidobacterium, may counteract these decreases, leading to enhanced gut health and improved quality of livestock food products. This study enhances our understanding of the correlation between overcrowding stress and the gut microbiota, providing valuable data for improving the management environment in livestock farming. |
| Author | Kim, Heebal Eo, Kyungsun Lee, Chaewon Huh, Chul Sung Park, Hyunjoon Yeo, Soyoung Yeom, Su Cheong |
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| Cites_doi | 10.3390/nu15143122 10.3748/wjg.v20.i41.15163 10.1128/IAI.66.11.5477-5484.1998 10.1093/cercor/bhae056 10.1111/j.1572-0241.2000.02012.x 10.1111/j.1469-7793.1998.549bt.x 10.3920/BM2015.0156 10.1038/tp.2016.191 10.1159/000050681 10.1016/j.prevetmed.2020.105147 10.1016/j.cell.2023.05.001 10.1264/jsme2.ME14176 10.1523/JNEUROSCI.0004-11.2011 10.3109/00365529209011167 10.15698/mic2017.04.569 10.1071/MA20022 10.1038/s41598-019-40140-5 10.1111/asj.13008 10.1038/nmeth.3869 10.1093/nar/gks1219 10.1080/19490976.2022.2057778 10.1053/jpsu.2000.0350539 10.1371/journal.pcbi.1009442 10.1038/s41387-020-0115-8 10.1093/bioinformatics/btx617 10.3390/app112412000 10.3168/jds.2016-11293 10.1038/s41586-019-1443-5 10.1159/000050673 10.1523/JNEUROSCI.0422-20.2021 10.1080/19490976.2021.2000275 10.2337/db11-0227 10.1111/jgh.14281 10.14309/ajg.0000000000000203 10.1128/AEM.05212-11 10.1111/j.1572-0241.2000.02252.x 10.1016/j.bbrc.2021.06.018 10.1038/srep45942 10.1007/s00253-021-11622-2 10.1080/08964289.1991.9937553 10.1002/brb3.1699 10.1146/annurev-animal-091020-075907 10.1007/BF00844770 10.1159/000533131 10.3389/fimmu.2024.1365871 10.1080/03079457.2013.874006 10.1210/en.2006-0347 10.1093/bioinformatics/btu170 10.1093/japr/10.4.329 10.1039/C8RA01432A 10.3748/wjg.v23.i30.5486 10.3389/fmicb.2022.805963 10.1093/nar/gkad407 10.1002/cne.903010107 10.1038/s41598-021-83284-z 10.3389/fnins.2015.00003 10.1186/s12917-019-2190-4 10.1177/1535370217694434 10.3389/fbioe.2021.770248 10.3390/cells10051028 10.1210/en.2004-0068 10.3168/jds.2015-10556 10.1080/10408398.2018.1517725 10.3923/ijps.2004.361.364 10.1016/S0165-1838(98)00074-5 10.3748/wjg.v20.i18.5212 10.1097/MPG.0000000000002226 10.3109/10253890802642188 10.1016/S0016-5085(00)70141-7 10.1136/gutjnl-2019-320105 |
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| Keywords | HiBiT system Bifidobacterium gut microbiota overcrowding stress neuronal nitric oxide synthase (nNOS) |
| Language | English |
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| References | Levenstein (key2.0250314095441e+13_B35) 2000; 95 Cheng (key2.0250314095441e+13_B14) 2021; 566 Reber (key2.0250314095441e+13_B54) 2006; 147 Mizuta (key2.0250314095441e+13_B44) 2000; 118 Uyeno (key2.0250314095441e+13_B59) 2015; 30 Yin (key2.0250314095441e+13_B67) 2021; 41 Ito (key2.0250314095441e+13_B30) 2017; 242 Ou (key2.0250314095441e+13_B49) 2020; 10 Weber (key2.0250314095441e+13_B65) 2017; 34 Chen (key2.0250314095441e+13_B11) 2015; 9 Blacher (key2.0250314095441e+13_B5) 2019; 572 Luo (key2.0250314095441e+13_B38) 2018; 8 Alawneh (key2.0250314095441e+13_B1) 2020; 183 Hu (key2.0250314095441e+13_B29) 2024; 34 Schneider (key2.0250314095441e+13_B55) 2023; 186 Peixoto (key2.0250314095441e+13_B52) 2021; 9 Ding (key2.0250314095441e+13_B18) 2021; 105 Krishnan (key2.0250314095441e+13_B34) 2020; 41 Berthoud (key2.0250314095441e+13_B4) 1990; 301 Everard (key2.0250314095441e+13_B21) 2011; 60 Delaroque (key2.0250314095441e+13_B17) 2021; 13 Han (key2.0250314095441e+13_B27) 2021; 10 Kellow (key2.0250314095441e+13_B33) 1992; 27 Yang (key2.0250314095441e+13_B66) 2017; 7 Wang (key2.0250314095441e+13_B61) 2011; 77 Ayala (key2.0250314095441e+13_B3) 2017; 4 McGaughey (key2.0250314095441e+13_B42) 2019; 9 Pang (key2.0250314095441e+13_B50) 2022; 88 De Vries (key2.0250314095441e+13_B16) 2016; 99 Partrick (key2.0250314095441e+13_B51) 2021; 11 Wang (key2.0250314095441e+13_B60) 2019; 114 Méndez-Palacios (key2.0250314095441e+13_B43) 2018; 89 Su (key2.0250314095441e+13_B57) 2000; 95 Estrada (key2.0250314095441e+13_B20) 2001; 10 Yunker (key2.0250314095441e+13_B68) 1998; 71 Henneke (key2.0250314095441e+13_B28) 2022; 14 Mallick (key2.0250314095441e+13_B40) 2021; 17 Zhai (key2.0250314095441e+13_B69) 2019; 59 Gomes (key2.0250314095441e+13_B25) 2014; 43 Quast (key2.0250314095441e+13_B53) 2012; 41 Zhou (key2.0250314095441e+13_B71) 2011; 31 Mönnikes (key2.0250314095441e+13_B46) 2001; 19 Nakao (key2.0250314095441e+13_B47) 1998; 507 Bolger (key2.0250314095441e+13_B7) 2014; 30 Cenit (key2.0250314095441e+13_B10) 2017; 23 Chen (key2.0250314095441e+13_B12) 2021; 9 Jensen (key2.0250314095441e+13_B31) 2019; 15 Wang (key2.0250314095441e+13_B62) 2020; 69 Zhang (key2.0250314095441e+13_B70) 2020; 10 Culpepper (key2.0250314095441e+13_B15) 2016; 7 Guo (key2.0250314095441e+13_B26) 2009; 12 Mogor (key2.0250314095441e+13_B45) 2021; 11 Budzyński (key2.0250314095441e+13_B8) 2014; 20 Li (key2.0250314095441e+13_B36) 1998; 66 Boehme (key2.0250314095441e+13_B6) 2023; 15 Fustini (key2.0250314095441e+13_B22) 2017; 100 Wang (key2.0250314095441e+13_B63) 2000; 35 Allen (key2.0250314095441e+13_B2) 2016; 6 Garrett (key2.0250314095441e+13_B23) 1991; 14 Kabir (key2.0250314095441e+13_B32) 2004; 3 Shirakawa (key2.0250314095441e+13_B56) 2004; 145 Warren (key2.0250314095441e+13_B64) 2024; 15 Chen (key2.0250314095441e+13_B13) 2018; 33 Nalla (key2.0250314095441e+13_B48) 2022; 13 Duffy (key2.0250314095441e+13_B19) 1991; 17 Gerards (key2.0250314095441e+13_B24) 2001; 19 Tojo (key2.0250314095441e+13_B58) 2014; 20 Callahan (key2.0250314095441e+13_B9) 2016; 13 Lu (key2.0250314095441e+13_B37) 2023; 51 Maltz (key2.0250314095441e+13_B41) 2019; 68 Ma (key2.0250314095441e+13_B39) 2023; 82 |
| References_xml | – volume: 15 start-page: 3122 year: 2023 ident: key2.0250314095441e+13_B6 article-title: Bifidobacterium longum subsp. longum reduces perceived psychological stress in healthy adults: An exploratory clinical trial publication-title: Nutrients doi: 10.3390/nu15143122 – volume: 20 start-page: 15163 year: 2014 ident: key2.0250314095441e+13_B58 article-title: Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis publication-title: World J Gastroenterol doi: 10.3748/wjg.v20.i41.15163 – volume: 66 start-page: 5477 year: 1998 ident: key2.0250314095441e+13_B36 article-title: SCID/NCr mice naturally infected with Helicobacter hepaticus develop progressive hepatitis, proliferative typhlitis, and colitis publication-title: Infect Immun doi: 10.1128/IAI.66.11.5477-5484.1998 – volume: 34 start-page: bhae056 year: 2024 ident: key2.0250314095441e+13_B29 article-title: A causal relationship between gut microbiota and subcortical brain structures contributes to the microbiota-gut-brain axis: A mendelian randomization study publication-title: Cereb Cortex doi: 10.1093/cercor/bhae056 – volume: 95 start-page: 1213 year: 2000 ident: key2.0250314095441e+13_B35 article-title: Stress and exacerbation in ulcerative colitis: A prospective study of patients enrolled in remission publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2000.02012.x – volume: 507 start-page: 549 year: 1998 ident: key2.0250314095441e+13_B47 article-title: Extrinsic neural control of nitric oxide synthase expression in the myenteric plexus of rat jejunum publication-title: J Physiol doi: 10.1111/j.1469-7793.1998.549bt.x – volume: 7 start-page: 327 year: 2016 ident: key2.0250314095441e+13_B15 article-title: Bifidobacterium bifidum R0071 decreases stress-associated diarrhoea-related symptoms and self-reported stress: A secondary analysis of a randomised trial publication-title: Benef Microbes doi: 10.3920/BM2015.0156 – volume: 6 year: 2016 ident: key2.0250314095441e+13_B2 article-title: Bifidobacterium longum 1714 as a translational psychobiotic: Modulation of stress, electrophysiology and neurocognition in healthy volunteers publication-title: Transl Psychiatry doi: 10.1038/tp.2016.191 – volume: 19 start-page: 201 year: 2001 ident: key2.0250314095441e+13_B46 article-title: Role of stress in functional gastrointestinal disorders: Evidence for stress-induced alterations in gastrointestinal motility and sensitivity publication-title: Dig Dis doi: 10.1159/000050681 – volume: 183 start-page: 105147 year: 2020 ident: key2.0250314095441e+13_B1 article-title: Systematic review of an intervention: The use of probiotics to improve health and productivity of calves publication-title: Prev Vet Med doi: 10.1016/j.prevetmed.2020.105147 – volume: 186 start-page: 2823 year: 2023 ident: key2.0250314095441e+13_B55 article-title: The enteric nervous system relays psychological stress to intestinal inflammation publication-title: Cell doi: 10.1016/j.cell.2023.05.001 – volume: 30 start-page: 126 year: 2015 ident: key2.0250314095441e+13_B59 article-title: Effect of probiotics/prebiotics on cattle health and productivity publication-title: Microbes Environ doi: 10.1264/jsme2.ME14176 – volume: 31 start-page: 7579 year: 2011 ident: key2.0250314095441e+13_B71 article-title: Hippocampal neuronal nitric oxide synthase mediates the stress-related depressive behaviors of glucocorticoids by downregulating glucocorticoid receptor publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0004-11.2011 – volume: 27 start-page: 53 year: 1992 ident: key2.0250314095441e+13_B33 article-title: Effects of acute psychologic stress on small-intestinal motility in health and the irritable bowel syndrome publication-title: Scand J Gastroenterol doi: 10.3109/00365529209011167 – volume: 4 start-page: 133 year: 2017 ident: key2.0250314095441e+13_B3 article-title: Microbial flora, probiotics, Bacillus subtilis and the search for a long and healthy human longevity publication-title: Microb Cell doi: 10.15698/mic2017.04.569 – volume: 41 start-page: 86 year: 2020 ident: key2.0250314095441e+13_B34 article-title: On the use of probiotics to improve dairy cattle health and productivity publication-title: Microbiol Aust doi: 10.1071/MA20022 – volume: 9 start-page: 3281 year: 2019 ident: key2.0250314095441e+13_B42 article-title: Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice publication-title: Sci Rep doi: 10.1038/s41598-019-40140-5 – volume: 89 start-page: 994 year: 2018 ident: key2.0250314095441e+13_B43 article-title: Productive and economic parameters of pigs supplemented from weaning to finishing with prebiotic and probiotic feed additives publication-title: Anim Sci J doi: 10.1111/asj.13008 – volume: 13 start-page: 581 year: 2016 ident: key2.0250314095441e+13_B9 article-title: DADA2: High-resolution sample inference from illumina amplicon data publication-title: Nat Methods doi: 10.1038/nmeth.3869 – volume: 41 start-page: D590 year: 2012 ident: key2.0250314095441e+13_B53 article-title: The SILVA ribosomal RNA gene database project: Improved data processing and web-based tools publication-title: Nucleic Acids Res doi: 10.1093/nar/gks1219 – volume: 14 start-page: 2057778 year: 2022 ident: key2.0250314095441e+13_B28 article-title: A dietary carbohydrate – gut parasutterella – human fatty acid biosynthesis metabolic axis in obesity and type 2 diabetes publication-title: Gut Microbes doi: 10.1080/19490976.2022.2057778 – volume: 35 start-page: 539 year: 2000 ident: key2.0250314095441e+13_B63 article-title: Involvement of endogenous nitric oxide and c-kit: Expressing cells in chronic intestinal pseudo-obstruction publication-title: J Pediatr Surg doi: 10.1053/jpsu.2000.0350539 – volume: 17 year: 2021 ident: key2.0250314095441e+13_B40 article-title: Multivariable association discovery in population-scale meta-omics studies publication-title: PLOS Comput Biol doi: 10.1371/journal.pcbi.1009442 – volume: 10 start-page: 12 year: 2020 ident: key2.0250314095441e+13_B49 article-title: Protective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer’s disease publication-title: Nutr Diabetes doi: 10.1038/s41387-020-0115-8 – volume: 34 start-page: 1411 year: 2017 ident: key2.0250314095441e+13_B65 article-title: Nephele: A cloud platform for simplified, standardized and reproducible microbiome data analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/btx617 – volume: 11 start-page: 12000 year: 2021 ident: key2.0250314095441e+13_B45 article-title: The enteric nervous system and the microenvironment of the gut: The translational aspects of the microbiome-gut-brain axis publication-title: Appl Sci doi: 10.3390/app112412000 – volume: 100 start-page: 620 year: 2017 ident: key2.0250314095441e+13_B22 article-title: Overstocking dairy cows during the dry period affects dehydroepiandrosterone and cortisol secretion publication-title: J Dairy Sci doi: 10.3168/jds.2016-11293 – volume: 572 start-page: 474 year: 2019 ident: key2.0250314095441e+13_B5 article-title: Potential roles of gut microbiome and metabolites in modulating ALS in mice publication-title: Nature doi: 10.1038/s41586-019-1443-5 – volume: 19 start-page: 170 year: 2001 ident: key2.0250314095441e+13_B24 article-title: H. pylori infection and visceral hypersensitivity in patients with irritable bowel syndrome publication-title: Dig Dis doi: 10.1159/000050673 – volume: 41 start-page: 2523 year: 2021 ident: key2.0250314095441e+13_B67 article-title: Neuronal nitric oxide synthase in nucleus accumbens specifically mediates susceptibility to social defeat stress through cyclin-dependent kinase 5 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0422-20.2021 – volume: 13 start-page: 2000275 year: 2021 ident: key2.0250314095441e+13_B17 article-title: Social overcrowding impacts gut microbiota, promoting stress, inflammation, and dysglycemia publication-title: Gut Microbes doi: 10.1080/19490976.2021.2000275 – volume: 60 start-page: 2775 year: 2011 ident: key2.0250314095441e+13_B21 article-title: Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice publication-title: Diabetes doi: 10.2337/db11-0227 – volume: 33 start-page: 1844 year: 2018 ident: key2.0250314095441e+13_B13 article-title: Parasutterella, in association with irritable bowel syndrome and intestinal chronic inflammation publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.14281 – volume: 114 start-page: 1152 year: 2019 ident: key2.0250314095441e+13_B60 article-title: Bifidobacterium longum 1714TM strain modulates brain activity of healthy volunteers during social stress publication-title: Am J Gasteroenterol doi: 10.14309/ajg.0000000000000203 – volume: 77 start-page: 6718 year: 2011 ident: key2.0250314095441e+13_B61 article-title: Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism publication-title: Appl Environ Microbiol doi: 10.1128/AEM.05212-11 – volume: 95 start-page: 1900 year: 2000 ident: key2.0250314095441e+13_B57 article-title: The association between Helicobacter pylori infection and functional dyspepsia in patients with irritable bowel syndrome publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2000.02252.x – volume: 566 start-page: 170 year: 2021 ident: key2.0250314095441e+13_B14 article-title: The outer membrane protein amuc_1100 of Akkermansia muciniphila alleviates the depression-like behavior of depressed mice induced by chronic stress publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2021.06.018 – volume: 88 year: 2022 ident: key2.0250314095441e+13_B50 article-title: Bifidobacterium animalis promotes the growth of weaning piglets by improving intestinal development, enhancing antioxidant capacity, and modulating gut microbiota publication-title: Food Microbiol – volume: 7 start-page: 45942 year: 2017 ident: key2.0250314095441e+13_B66 article-title: Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice publication-title: Sci Rep doi: 10.1038/srep45942 – volume: 105 start-page: 8411 year: 2021 ident: key2.0250314095441e+13_B18 article-title: A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress–induced depressive-like behavior in mice by regulating gut microbiota and metabolites publication-title: Appl Microbiol Biotechnol doi: 10.1007/s00253-021-11622-2 – volume: 17 start-page: 101 year: 1991 ident: key2.0250314095441e+13_B19 article-title: Relevance of major stress events as an indicator of disease activity prevalence in inflammatory bowel disease publication-title: Behav Med doi: 10.1080/08964289.1991.9937553 – volume: 10 year: 2020 ident: key2.0250314095441e+13_B70 article-title: Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta-analysis based on randomized controlled trials publication-title: Brain Behav doi: 10.1002/brb3.1699 – volume: 9 start-page: 289 year: 2021 ident: key2.0250314095441e+13_B52 article-title: Advances in microbiome research for animal health publication-title: Annu Rev Anim Biosci doi: 10.1146/annurev-animal-091020-075907 – volume: 14 start-page: 87 year: 1991 ident: key2.0250314095441e+13_B23 article-title: The relation between daily stress and Crohn’s disease publication-title: J Behav Med doi: 10.1007/BF00844770 – volume: 82 start-page: 247 year: 2023 ident: key2.0250314095441e+13_B39 article-title: Psychological stress and gut microbiota composition: A systematic review of human studies publication-title: Neuropsychobiology doi: 10.1159/000533131 – volume: 15 start-page: 1365871 year: 2024 ident: key2.0250314095441e+13_B64 article-title: Dangers of the chronic stress response in the context of the microbiota-gut-immune-brain axis and mental health: A narrative review publication-title: Front Immunol doi: 10.3389/fimmu.2024.1365871 – volume: 43 start-page: 82 year: 2014 ident: key2.0250314095441e+13_B25 article-title: Overcrowding stress decreases macrophage activity and increases Salmonella Enteritidis invasion in broiler chickens publication-title: Avian Pathol doi: 10.1080/03079457.2013.874006 – volume: 147 start-page: 4968 year: 2006 ident: key2.0250314095441e+13_B54 article-title: Chronic intermittent psychosocial stress (social defeat/ overcrowding) in mice increases the severity of an acute DSS-induced colitis and impairs regeneration publication-title: Endocrinology doi: 10.1210/en.2006-0347 – volume: 30 start-page: 2114 year: 2014 ident: key2.0250314095441e+13_B7 article-title: Trimmomatic: A flexible trimmer for illumina sequence data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 – volume: 10 start-page: 329 year: 2001 ident: key2.0250314095441e+13_B20 article-title: Administration of Bifidobacterium bifidum to chicken broilers reduces the number of carcass condemnations for cellulitis at the abattoir publication-title: J Appl Poult Res doi: 10.1093/japr/10.4.329 – volume: 8 start-page: 20166 year: 2018 ident: key2.0250314095441e+13_B38 article-title: Association between metabolic profile and microbiomic changes in rats with functional dyspepsia publication-title: RSC Adv doi: 10.1039/C8RA01432A – volume: 23 start-page: 5486 year: 2017 ident: key2.0250314095441e+13_B10 article-title: Influence of gut microbiota on neuropsychiatric disorders publication-title: World J Gastroenterol doi: 10.3748/wjg.v23.i30.5486 – volume: 13 start-page: 805963 year: 2022 ident: key2.0250314095441e+13_B48 article-title: Impact of probiotics on dairy production efficiency publication-title: Front Microbiol doi: 10.3389/fmicb.2022.805963 – volume: 51 start-page: W310 year: 2023 ident: key2.0250314095441e+13_B37 article-title: Microbiomeanalyst 2.0: Comprehensive statistical, functional and integrative analysis of microbiome data publication-title: Nucleic Acids Res doi: 10.1093/nar/gkad407 – volume: 301 start-page: 65 year: 1990 ident: key2.0250314095441e+13_B4 article-title: Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with dil injected into the dorsal vagal complex in the rat publication-title: J Comp Neurol doi: 10.1002/cne.903010107 – volume: 11 start-page: 3763 year: 2021 ident: key2.0250314095441e+13_B51 article-title: Ingestion of probiotic (Lactobacillus helveticus and Bifidobacterium longum) alters intestinal microbial structure and behavioral expression following social defeat stress publication-title: Sci Rep doi: 10.1038/s41598-021-83284-z – volume: 9 start-page: 3 year: 2015 ident: key2.0250314095441e+13_B11 article-title: Response of the nitrergic system to activation of the neuroendocrine stress axis publication-title: Front Neurosci doi: 10.3389/fnins.2015.00003 – volume: 15 start-page: 442 year: 2019 ident: key2.0250314095441e+13_B31 article-title: Case-control study on factors associated with a decreased milk yield and a depressed health status of dairy herds in northern Germany publication-title: BMC Vet Res doi: 10.1186/s12917-019-2190-4 – volume: 242 start-page: 762 year: 2017 ident: key2.0250314095441e+13_B30 article-title: Inducible and neuronal nitric oxide synthases exert contrasting effects during rat intestinal recovery following fasting publication-title: Exp Biol Med doi: 10.1177/1535370217694434 – volume: 9 start-page: 770248 year: 2021 ident: key2.0250314095441e+13_B12 article-title: Recent development of probiotic bifidobacteria for treating human diseases publication-title: Front Bioeng Biotechnol doi: 10.3389/fbioe.2021.770248 – volume: 10 start-page: 1028 year: 2021 ident: key2.0250314095441e+13_B27 article-title: Positive correlation between nNOS and stress-activated bowel motility is confirmed by in vivo HiBiT system publication-title: Cells doi: 10.3390/cells10051028 – volume: 145 start-page: 3603 year: 2004 ident: key2.0250314095441e+13_B56 article-title: Immobilization induces acute nitric oxide production in the rat hypothalamus: A role of ionotropic glutamate receptors in the paraventricular nucleus publication-title: Endocrinology doi: 10.1210/en.2004-0068 – volume: 99 start-page: 3848 year: 2016 ident: key2.0250314095441e+13_B16 article-title: Economic evaluation of stall stocking density of lactating dairy cows publication-title: J Dairy Sci doi: 10.3168/jds.2015-10556 – volume: 59 start-page: 3227 year: 2019 ident: key2.0250314095441e+13_B69 article-title: A next generation probiotic, Akkermansia muciniphila publication-title: Crit Rev Food Sci Nutr doi: 10.1080/10408398.2018.1517725 – volume: 3 start-page: 361 year: 2004 ident: key2.0250314095441e+13_B32 article-title: The dynamics of probiotics on growth performance and immune response in broilers publication-title: Int J Poult Sci doi: 10.3923/ijps.2004.361.364 – volume: 71 start-page: 148 year: 1998 ident: key2.0250314095441e+13_B68 article-title: Extrinsic denervation increases myenteric nitric oxide synthase-containing neurons and inhibitory neuromuscular transmission in guinea pig publication-title: J Auton Nerv Syst doi: 10.1016/S0165-1838(98)00074-5 – volume: 20 start-page: 5212 year: 2014 ident: key2.0250314095441e+13_B8 article-title: Brain-gut axis in the pathogenesis of helicobacter pylori infection publication-title: World J Gastroenterol doi: 10.3748/wjg.v20.i18.5212 – volume: 68 start-page: 533 year: 2019 ident: key2.0250314095441e+13_B41 article-title: Social stress affects colonic inflammation, the gut microbiome, and short-chain fatty acid levels and receptors publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/MPG.0000000000002226 – volume: 12 start-page: 478 year: 2009 ident: key2.0250314095441e+13_B26 article-title: Psychological stress enhances the colonization of the stomach by Helicobacter pylori in the BALB/c mouse publication-title: Stress doi: 10.3109/10253890802642188 – volume: 118 start-page: 714 year: 2000 ident: key2.0250314095441e+13_B44 article-title: Impaired nitrergic innervation in rat colitis induced by dextran sulfate sodium publication-title: Gastroenterology doi: 10.1016/S0016-5085(00)70141-7 – volume: 69 start-page: 1988 year: 2020 ident: key2.0250314095441e+13_B62 article-title: A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice publication-title: Gut doi: 10.1136/gutjnl-2019-320105 |
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| Title | Overcrowding Stress in Livestock Production Alters Gut Microbiota Composition and Neuronal Nitric Oxide Synthase (nNOS) Expression in nNOS-HiBiT Knock-in Mouse Model |
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