NrCAM activates the NF‐κB signalling pathway by competitively binding to SUMO‐1 and promotes Th17 cell differentiation in Graves' disease - Huang, Fengjiao; Zhang, Lijuan; Zhou, Yingying; Zhao, Shuiying; Wang, Jiao (Scandinavian journal of immunology, 2024)
Keywords: Adult; CD4 antigen; Cell activation; Cell adhesion molecules; Cell differentiation; Cell Differentiation - immunology; Cells, Cultured; Female; Graves disease; Graves Disease - immunology; Graves Disease - metabolism; Helper cells; Humans; Interleukins - genetics; Interleukins - metabolism; Leukocytes (mononuclear); Lymphocytes; Lymphocytes T; Male; Middle Aged; Molecular modelling; NF-kappa B - metabolism; NF-KappaB Inhibitor alpha - metabolism; NF‐κB; Nitriles - pharmacology; NrCAM; Peripheral blood mononuclear cells; Phosphorylation; Protein Binding; Rel protein; Signal transduction; Signal Transduction - immunology; Sulfones - pharmacology; SUMO-1 Protein - metabolism; SUMO‐1; Th17 cell differentiation; Th17 Cells - immunology; Th17 Cells - metabolism; Ubiquitin; NF‐κB; NrCAM; Th17 cell differentiation; Graves' disease; SUMO‐1