Computational profiling and pharmacokinetic modelling of Febuxostat: Evaluating its potential as a therapeutic agent for diabetic wound healing - Nirenjen, S.; Narayanan, J. (Biochimica et biophysica acta. General subjects, 2025)
Keywords: Animals; Cell Line; Cell Movement - drug effects; Cell Survival - drug effects; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetic wounds; Febuxostat; Febuxostat - pharmacokinetics; Febuxostat - pharmacology; Humans; Inflammation; Mice; Molecular docking; Molecular Docking Simulation; Molecular dynamics; Molecular Dynamics Simulation; MRSA infections; Vascular Endothelial Growth Factor A - metabolism; Wound healing; Wound Healing - drug effects; T2DM; MRSA infections; Diabetic wounds; Molecular dynamics; NFkB; ADMET; Molecular docking; PDB; MRSA; MD; TGF-β; GSK; Wound healing; Febuxostat; VEGF; IKK; Inflammation; RMSD; COX; TPSA; DHFR; OPLS4; TNF-α; PASS; ROS; GPCR; TIP3P; MMP-9