Azoxystrobin, a mitochondrial complex III Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitro - Gao, An-Hui; Fu, Yan-Yun; Zhang, Kun-Zhi; Zhang, Mei; Jiang, Hao-Wen; Fan, Li-Xia; Nan, Fa-Jun; Yuan, Chong-Gang; Li, Jia; Zhou, Yu-Bo; Li, Jing-Ya (Biochimica et biophysica acta, 2014)
Keywords: adipocytes; Adipogenesis - genetics; AMP-activated protein kinase; animal models; Animals; Azoxystrobin; Diet, High-Fat; drugs; electron transport chain; Electron Transport Complex III - antagonists & inhibitors; Electron Transport Complex III - metabolism; Energy Metabolism - genetics; gene expression; Gene Expression Regulation; glucose; Glucose - metabolism; glucose tolerance; Hep G2 Cells; homeostasis; human cell lines; Humans; insulin resistance; Lipid Metabolism; lipogenesis; liver; Liver - metabolism; Metabolic diseases; metabolic syndrome; Methacrylates - administration & dosage; Methacrylates - metabolism; Mice; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria complex III; myotubes; obesity; Obesity - drug therapy; Obesity - metabolism; Obesity - pathology; Pyrimidines - administration & dosage; Pyrimidines - metabolism; Strobilurins; triacylglycerols; Triglycerides - metabolism; ubiquinol-cytochrome-c reductase; Azoxystrobin; Metabolic diseases; AMP-activated protein kinase; Mitochondria complex III