Genetic Risk Score Constructed from Polymorphisms in the VEGFA, TBX5, and SMAD7 Genes Provides Novel Insights into the Molecular Mechanisms of the Tetralogy of Fallot and Ventricular Septal Defect (Case-Control Study from the Pakistani Population)

Congenital heart defects are common and complex birth-defect malformations in developed and developing countries. It is a multifactorial disease that involves the interaction of either gene-gene or gene-environment. This comparative study was the first report on the genotypic-phenotypic correlation...

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Published inThe American journal of cardiology Vol. 203; pp. 368 - 375
Main Authors Ashiq, Sana, Sabar, Muhammad Farooq, Hyder, Syed Najam
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.09.2023
Elsevier Limited
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Online AccessGet full text
ISSN0002-9149
1879-1913
1879-1913
DOI10.1016/j.amjcard.2023.06.070

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Abstract Congenital heart defects are common and complex birth-defect malformations in developed and developing countries. It is a multifactorial disease that involves the interaction of either gene-gene or gene-environment. This comparative study was the first report on the genotypic-phenotypic correlation in the Pakistani population. The single nucleotide polymorphisms (SNPs) were further tested for association with maternal diabetes mellitus or hypertension. In addition, the cumulative genetic risk score (GRS) for low to moderately-associated SNPs was calculated for each study subject, which can ultimately guide us for better therapeutic options and prevention strategies. According to the predefined selection criteria, 376 subjects were recruited. The multiplex mini-sequencing genotyping technique opted for the cost-effective genotyping of selected loci. The association of variants with the disease was examined using logistic regression analysis. The statistical and graphical analysis was conducted using SPSS, Haploview, SNPStats, and GraphPad Prism. The results for all SNPs analysis suggested a nonsignificant association with overall congenital heart defect risk except rs3809923. However, interestingly on stratified analysis variants, rs3809923 and rs3809922 showed an association only with tetralogy of Fallot. The remaining risk factor analysis for maternal hypertension and diabetes mellitus association with SNPs were nonsignificant. The GRS was the first time constructed for this low to moderately-associated variants. Interestingly, the cumulative GRS was significantly different from the control group revealing the cumulative effect of these polymorphisms panel in patients. In conclusion, the use of GRS in the clinical setting can predict better risk association and patient outcomes.
AbstractList Congenital heart defects are common and complex birth-defect malformations in developed and developing countries. It is a multifactorial disease that involves the interaction of either gene-gene or gene-environment. This comparative study was the first report on the genotypic-phenotypic correlation in the Pakistani population. The single nucleotide polymorphisms (SNPs) were further tested for association with maternal diabetes mellitus or hypertension. In addition, the cumulative genetic risk score (GRS) for low to moderately-associated SNPs was calculated for each study subject, which can ultimately guide us for better therapeutic options and prevention strategies. According to the predefined selection criteria, 376 subjects were recruited. The multiplex mini-sequencing genotyping technique opted for the cost-effective genotyping of selected loci. The association of variants with the disease was examined using logistic regression analysis. The statistical and graphical analysis was conducted using SPSS, Haploview, SNPStats, and GraphPad Prism. The results for all SNPs analysis suggested a nonsignificant association with overall congenital heart defect risk except rs3809923. However, interestingly on stratified analysis variants, rs3809923 and rs3809922 showed an association only with tetralogy of Fallot. The remaining risk factor analysis for maternal hypertension and diabetes mellitus association with SNPs were nonsignificant. The GRS was the first time constructed for this low to moderately-associated variants. Interestingly, the cumulative GRS was significantly different from the control group revealing the cumulative effect of these polymorphisms panel in patients. In conclusion, the use of GRS in the clinical setting can predict better risk association and patient outcomes.
Congenital heart defects are common and complex birth-defect malformations in developed and developing countries. It is a multifactorial disease that involves the interaction of either gene-gene or gene-environment. This comparative study was the first report on the genotypic-phenotypic correlation in the Pakistani population. The single nucleotide polymorphisms (SNPs) were further tested for association with maternal diabetes mellitus or hypertension. In addition, the cumulative genetic risk score (GRS) for low to moderately-associated SNPs was calculated for each study subject, which can ultimately guide us for better therapeutic options and prevention strategies. According to the predefined selection criteria, 376 subjects were recruited. The multiplex mini-sequencing genotyping technique opted for the cost-effective genotyping of selected loci. The association of variants with the disease was examined using logistic regression analysis. The statistical and graphical analysis was conducted using SPSS, Haploview, SNPStats, and GraphPad Prism. The results for all SNPs analysis suggested a nonsignificant association with overall congenital heart defect risk except rs3809923. However, interestingly on stratified analysis variants, rs3809923 and rs3809922 showed an association only with tetralogy of Fallot. The remaining risk factor analysis for maternal hypertension and diabetes mellitus association with SNPs were nonsignificant. The GRS was the first time constructed for this low to moderately-associated variants. Interestingly, the cumulative GRS was significantly different from the control group revealing the cumulative effect of these polymorphisms panel in patients. In conclusion, the use of GRS in the clinical setting can predict better risk association and patient outcomes.Congenital heart defects are common and complex birth-defect malformations in developed and developing countries. It is a multifactorial disease that involves the interaction of either gene-gene or gene-environment. This comparative study was the first report on the genotypic-phenotypic correlation in the Pakistani population. The single nucleotide polymorphisms (SNPs) were further tested for association with maternal diabetes mellitus or hypertension. In addition, the cumulative genetic risk score (GRS) for low to moderately-associated SNPs was calculated for each study subject, which can ultimately guide us for better therapeutic options and prevention strategies. According to the predefined selection criteria, 376 subjects were recruited. The multiplex mini-sequencing genotyping technique opted for the cost-effective genotyping of selected loci. The association of variants with the disease was examined using logistic regression analysis. The statistical and graphical analysis was conducted using SPSS, Haploview, SNPStats, and GraphPad Prism. The results for all SNPs analysis suggested a nonsignificant association with overall congenital heart defect risk except rs3809923. However, interestingly on stratified analysis variants, rs3809923 and rs3809922 showed an association only with tetralogy of Fallot. The remaining risk factor analysis for maternal hypertension and diabetes mellitus association with SNPs were nonsignificant. The GRS was the first time constructed for this low to moderately-associated variants. Interestingly, the cumulative GRS was significantly different from the control group revealing the cumulative effect of these polymorphisms panel in patients. In conclusion, the use of GRS in the clinical setting can predict better risk association and patient outcomes.
Author Ashiq, Sana
Sabar, Muhammad Farooq
Hyder, Syed Najam
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Cites_doi 10.1113/JP276758
10.3109/02770903.2015.1124441
10.1161/CIRCGEN.121.003500
10.3892/etm.2022.11240
10.3390/ijms21155294
10.4103/0974-2069.189125
10.1017/S1047951120004874
10.1038/npjgenmed.2016.31
10.3389/fcvm.2021.653244
10.1002/mgg3.612
10.1161/JAHA.119.015255
10.1371/journal.pone.0072423
10.1007/s11033-023-08418-0
10.1089/gtmb.2014.0303
10.1080/08977194.2018.1513505
10.1093/ije/dyz009
10.1186/s43044-021-00199-w
10.1007/s10654-020-00653-0
10.1016/j.ijcard.2022.09.021
10.1016/S2352-4642(19)30402-X
10.1161/CIRCRESAHA.112.300853
10.1371/journal.pone.0004978
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Keywords GRS
Congenital heart defect
SNP
tetralogy of Fallot
Language English
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References Ashiq, Ashiq, Sabar (bib0001) 2021; 73
Sabar, Ghani, Shahid, Sumrin, Ali, Akram, Tariq, Bano (bib0009) 2016; 53
Fahed, Gelb, Seidman, Seidman (bib0012) 2013; 112
Kodo, Uchida, Yamagishi (bib0008) 2021; 8
Colliva, Braga, Giacca, Zacchigna (bib0014) 2020; 598
Spendlove, Bondhus, Lluri, Sul, Arboleda (bib0011) 2022; 3
Griffin, Hall, Topf, Eden, Stuart, Parsons, Peart, Deanfield, O'Sullivan, Babu-Narayan, Gatzoulis, Bu'lock, Bhattacharya, Bentham, Farrall, Granados Riveron, Brook, Burn, Cordell, Goodship, Keavney (bib0020) 2009; 4
Rashid, Qureshi, Hyder, Sadiq (bib0019) 2016; 9
Yan, Ge, Xi, Zhang, Guo (bib0021) 2015; 19
Zhao, Chen, Yang, Wang, Zhang, Chen, Ye, Luo, Qin (bib0003) 2020; 35
Ashiq, Sabar (bib0018) 2023; 50
Costain, Silversides, Bassett (bib0006) 2016; 1
Liu, Chen, Zühlke, Black, Choy, Li, Keavney (bib0005) 2019; 48
Braile, Marcella, Cristinziano, Galdiero, Modestino, Ferrara, Varricchi, Marone, Loffredo (bib0013) 2020; 21
Peyvandi, Baer, Chambers, Norton, Rajagopal, Ryckman, Moon-Grady, Jelliffe-Pawlowski, Steurer (bib0007) 2020; 9
Wang, Jin, Duan, Qiao, Sun, Huang, Shi, Jin, Wang (bib0017) 2013; 8
Borghini, Vecoli, Mercuri, Turchi, Andreassi (bib0010) 2021; 31
Zhu, Qiao, Wang, Mi, Chen, Lu, Gu, Zheng (bib0016) 2017; 9
Behiry, Al-Azzouny, Sabry, Behairy, Salem (bib0023) 2019; 7
Abhinav, Zhang, Zhao, Xu, Wang, Yang (bib0002) 2022; 23
Wang, Xu, Xu (bib0015) 2018; 36
Zimmerman, Smith, Sable, Echko, Wilner, Olsen, Atalay, Awasthi, Bhutta, Boucher, Castro (bib0004) 2020; 4
Woudstra, Skoric-Milosavljevic, Mulder, Meijboom, Post, Jongbloed, van Dijk, van Melle, Konings, Postma, Bezzina, Bouma, Tanck (bib0025) 2023; 371
Morton, Pereira, Quiat, Richter, Kitaygorodsky, Hagen, Bernstein, Brueckner, Goldmuntz, Kim, Lifton, Porter, Tristani-Firouzi, Chung, Roberts, Gelb, Shen, Newburger, Seidman, Seidman (bib0024) 2022; 15
Mohamed Sa'dom, Hashim, Maran, Mohd Zain, Wan Ibrahim, Wong, Corno, Wan Taib, Tan (bib0022) 2016; 6
Costain (10.1016/j.amjcard.2023.06.070_bib0006) 2016; 1
Abhinav (10.1016/j.amjcard.2023.06.070_bib0002) 2022; 23
Braile (10.1016/j.amjcard.2023.06.070_bib0013) 2020; 21
Liu (10.1016/j.amjcard.2023.06.070_bib0005) 2019; 48
Ashiq (10.1016/j.amjcard.2023.06.070_bib0001) 2021; 73
Zhao (10.1016/j.amjcard.2023.06.070_bib0003) 2020; 35
Colliva (10.1016/j.amjcard.2023.06.070_bib0014) 2020; 598
Behiry (10.1016/j.amjcard.2023.06.070_bib0023) 2019; 7
Zimmerman (10.1016/j.amjcard.2023.06.070_bib0004) 2020; 4
Sabar (10.1016/j.amjcard.2023.06.070_bib0009) 2016; 53
Fahed (10.1016/j.amjcard.2023.06.070_bib0012) 2013; 112
Griffin (10.1016/j.amjcard.2023.06.070_bib0020) 2009; 4
Peyvandi (10.1016/j.amjcard.2023.06.070_bib0007) 2020; 9
Morton (10.1016/j.amjcard.2023.06.070_bib0024) 2022; 15
Woudstra (10.1016/j.amjcard.2023.06.070_bib0025) 2023; 371
Yan (10.1016/j.amjcard.2023.06.070_bib0021) 2015; 19
Rashid (10.1016/j.amjcard.2023.06.070_bib0019) 2016; 9
Wang (10.1016/j.amjcard.2023.06.070_bib0015) 2018; 36
Zhu (10.1016/j.amjcard.2023.06.070_bib0016) 2017; 9
Ashiq (10.1016/j.amjcard.2023.06.070_bib0018) 2023; 50
Wang (10.1016/j.amjcard.2023.06.070_bib0017) 2013; 8
Borghini (10.1016/j.amjcard.2023.06.070_bib0010) 2021; 31
Kodo (10.1016/j.amjcard.2023.06.070_bib0008) 2021; 8
Spendlove (10.1016/j.amjcard.2023.06.070_bib0011) 2022; 3
Mohamed Sa'dom (10.1016/j.amjcard.2023.06.070_bib0022) 2016; 6
References_xml – volume: 9
  start-page: 210
  year: 2016
  end-page: 215
  ident: bib0019
  article-title: Pattern of congenital heart disease in a developing country tertiary care center: factors associated with delayed diagnosis
  publication-title: Ann Pediatr Cardiol
– volume: 48
  start-page: 455
  year: 2019
  end-page: 463
  ident: bib0005
  article-title: Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies
  publication-title: Int J Epidemiol
– volume: 35
  start-page: 631
  year: 2020
  end-page: 642
  ident: bib0003
  article-title: Birth prevalence of congenital heart disease in China, 1980–2019: a systematic review and meta-analysis of 617 studies
  publication-title: Eur J Epidemiol
– volume: 3
  year: 2022
  ident: bib0011
  article-title: Polygenic risk scores of endo-phenotypes identify the effect of genetic background in congenital heart disease
  publication-title: HGG Adv
– volume: 50
  start-page: 5013
  year: 2023
  end-page: 5020
  ident: bib0018
  article-title: Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population
  publication-title: Mol Biol Rep
– volume: 8
  year: 2021
  ident: bib0008
  article-title: Genetic and cellular interaction during cardiovascular development implicated in congenital heart diseases
  publication-title: Front Cardiovasc Med
– volume: 21
  start-page: 5294
  year: 2020
  ident: bib0013
  article-title: VEGF-A in cardiomyocytes and heart diseases
  publication-title: Int J Mol Sci
– volume: 4
  start-page: e4978
  year: 2009
  ident: bib0020
  article-title: Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation
  publication-title: PLoS One
– volume: 23
  start-page: 1
  year: 2022
  end-page: 9
  ident: bib0002
  article-title: A novel
  publication-title: Exp Ther Med
– volume: 112
  start-page: 707
  year: 2013
  end-page: 720
  ident: bib0012
  article-title: Genetics of congenital heart disease: the glass half empty
  publication-title: Circ Res
– volume: 9
  start-page: 442
  year: 2017
  end-page: 453
  ident: bib0016
  article-title: T-box family of transcription factor-TBX5, insights in development and disease
  publication-title: Am J Transl Res
– volume: 1
  start-page: 16031
  year: 2016
  ident: bib0006
  article-title: The importance of copy number variation in congenital heart disease
  publication-title: NPJ Genom Med
– volume: 73
  start-page: 72
  year: 2021
  ident: bib0001
  article-title: The role of NKX2-5 gene polymorphisms in congenital heart disease (CHD): a systematic review and meta-analysis
  publication-title: Egypt Heart J
– volume: 6
  start-page: 138
  year: 2016
  end-page: 145
  ident: bib0022
  article-title: Screening of SMAD7 in Malay patients with ventricular septal defect
  publication-title: Am J Cardiovasc Dis
– volume: 31
  start-page: 965
  year: 2021
  end-page: 968
  ident: bib0010
  article-title: Individual and joint effects of genetic polymorphisms in microRNA-machinery genes on congenital heart disease susceptibility
  publication-title: Cardiol Young
– volume: 53
  start-page: 341
  year: 2016
  end-page: 348
  ident: bib0009
  article-title: Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan
  publication-title: J Asthma
– volume: 15
  year: 2022
  ident: bib0024
  article-title: Genome-wide de novo variants in congenital heart disease are not associated with maternal diabetes or obesity
  publication-title: Circ Genom Precis Med
– volume: 4
  start-page: 185
  year: 2020
  end-page: 200
  ident: bib0004
  article-title: Global, regional, and national burden of congenital heart disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
  publication-title: Lancet Child Adolesc Health
– volume: 36
  start-page: 232
  year: 2018
  end-page: 238
  ident: bib0015
  article-title: The roles of vascular endothelial growth factor gene polymorphisms in congenital heart diseases: a meta-analysis
  publication-title: Growth Factors
– volume: 9
  year: 2020
  ident: bib0007
  article-title: Environmental and socioeconomic factors influence the live-born incidence of congenital heart disease: a population-based study in California
  publication-title: J Am Heart Assoc
– volume: 8
  start-page: e72423
  year: 2013
  ident: bib0017
  article-title: Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population
  publication-title: PLoS One
– volume: 7
  start-page: e612
  year: 2019
  ident: bib0023
  article-title: Association of NKX2-5, GATA4, and TBX5 polymorphisms with congenital heart disease in Egyptian children
  publication-title: Mol Genet Genomic Med
– volume: 19
  start-page: 264
  year: 2015
  end-page: 271
  ident: bib0021
  article-title: Genetic variations of VEGF gene were associated with tetralogy of Fallot risk in a Chinese Han population
  publication-title: Genet Test Mol Biomarkers
– volume: 371
  start-page: 153
  year: 2023
  end-page: 159
  ident: bib0025
  article-title: Common genetic variants improve risk stratification after the atrial switch operation for transposition of the great arteries
  publication-title: Int J Cardiol
– volume: 598
  start-page: 2923
  year: 2020
  end-page: 2939
  ident: bib0014
  article-title: Endothelial cell–cardiomyocyte crosstalk in heart development and disease
  publication-title: J Physiol
– volume: 9
  start-page: 442
  year: 2017
  ident: 10.1016/j.amjcard.2023.06.070_bib0016
  article-title: T-box family of transcription factor-TBX5, insights in development and disease
  publication-title: Am J Transl Res
– volume: 598
  start-page: 2923
  year: 2020
  ident: 10.1016/j.amjcard.2023.06.070_bib0014
  article-title: Endothelial cell–cardiomyocyte crosstalk in heart development and disease
  publication-title: J Physiol
  doi: 10.1113/JP276758
– volume: 53
  start-page: 341
  year: 2016
  ident: 10.1016/j.amjcard.2023.06.070_bib0009
  article-title: Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan
  publication-title: J Asthma
  doi: 10.3109/02770903.2015.1124441
– volume: 6
  start-page: 138
  year: 2016
  ident: 10.1016/j.amjcard.2023.06.070_bib0022
  article-title: Screening of SMAD7 in Malay patients with ventricular septal defect
  publication-title: Am J Cardiovasc Dis
– volume: 15
  year: 2022
  ident: 10.1016/j.amjcard.2023.06.070_bib0024
  article-title: Genome-wide de novo variants in congenital heart disease are not associated with maternal diabetes or obesity
  publication-title: Circ Genom Precis Med
  doi: 10.1161/CIRCGEN.121.003500
– volume: 23
  start-page: 1
  year: 2022
  ident: 10.1016/j.amjcard.2023.06.070_bib0002
  article-title: A novel KLF13 mutation underlying congenital patent ductus arteriosus and ventricular septal defect, as well as bicuspid aortic valve
  publication-title: Exp Ther Med
  doi: 10.3892/etm.2022.11240
– volume: 21
  start-page: 5294
  year: 2020
  ident: 10.1016/j.amjcard.2023.06.070_bib0013
  article-title: VEGF-A in cardiomyocytes and heart diseases
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21155294
– volume: 9
  start-page: 210
  year: 2016
  ident: 10.1016/j.amjcard.2023.06.070_bib0019
  article-title: Pattern of congenital heart disease in a developing country tertiary care center: factors associated with delayed diagnosis
  publication-title: Ann Pediatr Cardiol
  doi: 10.4103/0974-2069.189125
– volume: 31
  start-page: 965
  year: 2021
  ident: 10.1016/j.amjcard.2023.06.070_bib0010
  article-title: Individual and joint effects of genetic polymorphisms in microRNA-machinery genes on congenital heart disease susceptibility
  publication-title: Cardiol Young
  doi: 10.1017/S1047951120004874
– volume: 1
  start-page: 16031
  year: 2016
  ident: 10.1016/j.amjcard.2023.06.070_bib0006
  article-title: The importance of copy number variation in congenital heart disease
  publication-title: NPJ Genom Med
  doi: 10.1038/npjgenmed.2016.31
– volume: 8
  year: 2021
  ident: 10.1016/j.amjcard.2023.06.070_bib0008
  article-title: Genetic and cellular interaction during cardiovascular development implicated in congenital heart diseases
  publication-title: Front Cardiovasc Med
  doi: 10.3389/fcvm.2021.653244
– volume: 3
  year: 2022
  ident: 10.1016/j.amjcard.2023.06.070_bib0011
  article-title: Polygenic risk scores of endo-phenotypes identify the effect of genetic background in congenital heart disease
  publication-title: HGG Adv
– volume: 7
  start-page: e612
  year: 2019
  ident: 10.1016/j.amjcard.2023.06.070_bib0023
  article-title: Association of NKX2-5, GATA4, and TBX5 polymorphisms with congenital heart disease in Egyptian children
  publication-title: Mol Genet Genomic Med
  doi: 10.1002/mgg3.612
– volume: 9
  year: 2020
  ident: 10.1016/j.amjcard.2023.06.070_bib0007
  article-title: Environmental and socioeconomic factors influence the live-born incidence of congenital heart disease: a population-based study in California
  publication-title: J Am Heart Assoc
  doi: 10.1161/JAHA.119.015255
– volume: 8
  start-page: e72423
  year: 2013
  ident: 10.1016/j.amjcard.2023.06.070_bib0017
  article-title: Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0072423
– volume: 50
  start-page: 5013
  year: 2023
  ident: 10.1016/j.amjcard.2023.06.070_bib0018
  article-title: Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-023-08418-0
– volume: 19
  start-page: 264
  year: 2015
  ident: 10.1016/j.amjcard.2023.06.070_bib0021
  article-title: Genetic variations of VEGF gene were associated with tetralogy of Fallot risk in a Chinese Han population
  publication-title: Genet Test Mol Biomarkers
  doi: 10.1089/gtmb.2014.0303
– volume: 36
  start-page: 232
  year: 2018
  ident: 10.1016/j.amjcard.2023.06.070_bib0015
  article-title: The roles of vascular endothelial growth factor gene polymorphisms in congenital heart diseases: a meta-analysis
  publication-title: Growth Factors
  doi: 10.1080/08977194.2018.1513505
– volume: 48
  start-page: 455
  year: 2019
  ident: 10.1016/j.amjcard.2023.06.070_bib0005
  article-title: Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies
  publication-title: Int J Epidemiol
  doi: 10.1093/ije/dyz009
– volume: 73
  start-page: 72
  year: 2021
  ident: 10.1016/j.amjcard.2023.06.070_bib0001
  article-title: The role of NKX2-5 gene polymorphisms in congenital heart disease (CHD): a systematic review and meta-analysis
  publication-title: Egypt Heart J
  doi: 10.1186/s43044-021-00199-w
– volume: 35
  start-page: 631
  year: 2020
  ident: 10.1016/j.amjcard.2023.06.070_bib0003
  article-title: Birth prevalence of congenital heart disease in China, 1980–2019: a systematic review and meta-analysis of 617 studies
  publication-title: Eur J Epidemiol
  doi: 10.1007/s10654-020-00653-0
– volume: 371
  start-page: 153
  year: 2023
  ident: 10.1016/j.amjcard.2023.06.070_bib0025
  article-title: Common genetic variants improve risk stratification after the atrial switch operation for transposition of the great arteries
  publication-title: Int J Cardiol
  doi: 10.1016/j.ijcard.2022.09.021
– volume: 4
  start-page: 185
  year: 2020
  ident: 10.1016/j.amjcard.2023.06.070_bib0004
  article-title: Global, regional, and national burden of congenital heart disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
  publication-title: Lancet Child Adolesc Health
  doi: 10.1016/S2352-4642(19)30402-X
– volume: 112
  start-page: 707
  year: 2013
  ident: 10.1016/j.amjcard.2023.06.070_bib0012
  article-title: Genetics of congenital heart disease: the glass half empty
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.112.300853
– volume: 4
  start-page: e4978
  year: 2009
  ident: 10.1016/j.amjcard.2023.06.070_bib0020
  article-title: Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0004978
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Snippet Congenital heart defects are common and complex birth-defect malformations in developed and developing countries. It is a multifactorial disease that involves...
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SubjectTerms Cardiovascular disease
Comparative studies
Congenital defects
Congenital diseases
Congenital heart defect
Defects
Developing countries
Diabetes mellitus
Factor analysis
Genes
Genomics
Genotyping
GRS
Haplotypes
Health risk assessment
Heart
Hypertension
LDCs
Molecular modelling
Nucleotides
Population studies
Regression analysis
Risk analysis
Risk factors
Single-nucleotide polymorphism
Smad7 protein
SNP
Statistical analysis
Tetralogy of Fallot
Ventricle
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