Total-Body Dynamic Imaging and Kinetic Modeling of [ 18 F]F-AraG in Healthy Individuals and a Non–Small Cell Lung Cancer Patient Undergoing Anti–PD-1 Immunotherapy - Omidvari, Negar; Levi, Jelena; Abdelhafez, Yasser G.; Wang, Yiran; Nardo, Lorenzo; Daly, Megan E.; Wang, Guobao; Cherry, Simon R. (Journal of Nuclear Medicine, 2024)
Keywords: Adult; Aged; Apoptosis; Biomarkers; Blood; Cancer therapies; Carcinoma, Non-Small-Cell Lung - diagnostic imaging; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - immunology; Cell death; Clinical Investigation; Female; Fluorine isotopes; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - therapeutic use; Immune system; Immunopathogenesis; Immunotherapy; Kinetics; Lung cancer; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - drug therapy; Lung Neoplasms - immunology; Lymph nodes; Lymphocytes; Lymphocytes T; Male; Medical imaging; Middle Aged; Modelling; Models, Biological; Non-small cell lung carcinoma; Organs; Parameter estimation; Parameter identification; PD-1 protein; Pharmacokinetics; Positron emission; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Small cell lung carcinoma; Therapy; Tumor microenvironment; Tumors; Whole Body Imaging; NSCLC; T cells; immunotherapy; total-body PET; kinetic modeling