Exploring the link: DNA methylation and kidney injury markers in farmers exposed to glyphosate-surfactant herbicides

Glyphosate-surfactant herbicides (GSH), widely used herbicides, have raised concerns about their potential nephrotoxic effects. Despite extensive studies, the safety of GSH remains debatable. This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biom...

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Published in	Regulatory toxicology and pharmacology Vol. 156; p. 105765
Main Authors	Khacha-ananda, Supakit, Intayoung, Unchisa, Kohsuwan, Kanyapak, Wunnapuk, Klintean
Format	Journal Article
Language	English
Published	Netherlands Elsevier Inc 01.02.2025
Subjects	Adult Biomarkers - urine DNA methylation DNA Methylation - drug effects Farmers Female Glycine - adverse effects Glycine - analogs & derivatives Glycine - toxicity Glyphosate Hepatitis A Virus Cellular Receptor 1 Herbicides - adverse effects Herbicides - toxicity Humans IGFBP7 Kidney - drug effects Kidney Diseases - chemically induced Kidney Diseases - urine Kidney injury KIM-1 Male Middle Aged Occupational Exposure - adverse effects Surface-Active Agents - adverse effects Surface-Active Agents - toxicity TIMP2 KIM-1 TIMP2 DNA methylation IGFBP7 Glyphosate Kidney injury
Online Access	Get full text
ISSN	0273-2300 1096-0295 1096-0295
DOI	10.1016/j.yrtph.2024.105765

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Abstract	Glyphosate-surfactant herbicides (GSH), widely used herbicides, have raised concerns about their potential nephrotoxic effects. Despite extensive studies, the safety of GSH remains debatable. This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biomarkers—specifically DNA methylation, KIM-1, TIMP2, and IGFBP7—in farmers regularly exposed to these chemicals. Two urine samples, pre-task (0-h) and post-task (24-h), were collected to analyze these biomarkers. No significant immediate changes were observed post-exposure, possibly due to personal protective equipment use. Moderate positive correlations were found between IGFBP7 and KIM-1, and IGFBP7 and TIMP2, suggesting early kidney injury. About 50% of subjects had a biomarker ratio greater than 1, indicating increased levels of IGFBP7, TIMP2, and KIM-1 after GSH exposure. This indicates that farmers who regularly spray GSH are at high risk of exposure, potentially leading to significant renal injury. Further long-term studies are needed to assess the chronic effects and validate these biomarkers for monitoring renal health in populations exposed to glyphosate. [Display omitted] •Moderate correlations between renal biomarkers suggest early kidney injury and cell death from occupational GSH exposure.•About 50% of subjects showed increased biomarker levels post-exposure, indicating potential early renal response to GSH.•Results highlight the need for long-term studies to assess chronic GSH effects and validate renal biomarkers for monitoring.
AbstractList	Glyphosate-surfactant herbicides (GSH), widely used herbicides, have raised concerns about their potential nephrotoxic effects. Despite extensive studies, the safety of GSH remains debatable. This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biomarkers—specifically DNA methylation, KIM-1, TIMP2, and IGFBP7—in farmers regularly exposed to these chemicals. Two urine samples, pre-task (0-h) and post-task (24-h), were collected to analyze these biomarkers. No significant immediate changes were observed post-exposure, possibly due to personal protective equipment use. Moderate positive correlations were found between IGFBP7 and KIM-1, and IGFBP7 and TIMP2, suggesting early kidney injury. About 50% of subjects had a biomarker ratio greater than 1, indicating increased levels of IGFBP7, TIMP2, and KIM-1 after GSH exposure. This indicates that farmers who regularly spray GSH are at high risk of exposure, potentially leading to significant renal injury. Further long-term studies are needed to assess the chronic effects and validate these biomarkers for monitoring renal health in populations exposed to glyphosate. [Display omitted] •Moderate correlations between renal biomarkers suggest early kidney injury and cell death from occupational GSH exposure.•About 50% of subjects showed increased biomarker levels post-exposure, indicating potential early renal response to GSH.•Results highlight the need for long-term studies to assess chronic GSH effects and validate renal biomarkers for monitoring. Glyphosate-surfactant herbicides (GSH), widely used herbicides, have raised concerns about their potential nephrotoxic effects. Despite extensive studies, the safety of GSH remains debatable. This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biomarkers-specifically DNA methylation, KIM-1, TIMP2, and IGFBP7-in farmers regularly exposed to these chemicals. Two urine samples, pre-task (0-h) and post-task (24-h), were collected to analyze these biomarkers. No significant immediate changes were observed post-exposure, possibly due to personal protective equipment use. Moderate positive correlations were found between IGFBP7 and KIM-1, and IGFBP7 and TIMP2, suggesting early kidney injury. About 50% of subjects had a biomarker ratio greater than 1, indicating increased levels of IGFBP7, TIMP2, and KIM-1 after GSH exposure. This indicates that farmers who regularly spray GSH are at high risk of exposure, potentially leading to significant renal injury. Further long-term studies are needed to assess the chronic effects and validate these biomarkers for monitoring renal health in populations exposed to glyphosate.Glyphosate-surfactant herbicides (GSH), widely used herbicides, have raised concerns about their potential nephrotoxic effects. Despite extensive studies, the safety of GSH remains debatable. This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biomarkers-specifically DNA methylation, KIM-1, TIMP2, and IGFBP7-in farmers regularly exposed to these chemicals. Two urine samples, pre-task (0-h) and post-task (24-h), were collected to analyze these biomarkers. No significant immediate changes were observed post-exposure, possibly due to personal protective equipment use. Moderate positive correlations were found between IGFBP7 and KIM-1, and IGFBP7 and TIMP2, suggesting early kidney injury. About 50% of subjects had a biomarker ratio greater than 1, indicating increased levels of IGFBP7, TIMP2, and KIM-1 after GSH exposure. This indicates that farmers who regularly spray GSH are at high risk of exposure, potentially leading to significant renal injury. Further long-term studies are needed to assess the chronic effects and validate these biomarkers for monitoring renal health in populations exposed to glyphosate. Glyphosate-surfactant herbicides (GSH), widely used herbicides, have raised concerns about their potential nephrotoxic effects. Despite extensive studies, the safety of GSH remains debatable. This study aimed to determine if occupational exposure to GSH causes detectable changes in renal injury biomarkers-specifically DNA methylation, KIM-1, TIMP2, and IGFBP7-in farmers regularly exposed to these chemicals. Two urine samples, pre-task (0-h) and post-task (24-h), were collected to analyze these biomarkers. No significant immediate changes were observed post-exposure, possibly due to personal protective equipment use. Moderate positive correlations were found between IGFBP7 and KIM-1, and IGFBP7 and TIMP2, suggesting early kidney injury. About 50% of subjects had a biomarker ratio greater than 1, indicating increased levels of IGFBP7, TIMP2, and KIM-1 after GSH exposure. This indicates that farmers who regularly spray GSH are at high risk of exposure, potentially leading to significant renal injury. Further long-term studies are needed to assess the chronic effects and validate these biomarkers for monitoring renal health in populations exposed to glyphosate.
ArticleNumber	105765
Author	Kohsuwan, Kanyapak Intayoung, Unchisa Wunnapuk, Klintean Khacha-ananda, Supakit
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Keywords	KIM-1 TIMP2 DNA methylation IGFBP7 Glyphosate Kidney injury
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Snippet	Glyphosate-surfactant herbicides (GSH), widely used herbicides, have raised concerns about their potential nephrotoxic effects. Despite extensive studies, the...
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SubjectTerms	Adult Biomarkers - urine DNA methylation DNA Methylation - drug effects Farmers Female Glycine - adverse effects Glycine - analogs & derivatives Glycine - toxicity Glyphosate Hepatitis A Virus Cellular Receptor 1 Herbicides - adverse effects Herbicides - toxicity Humans IGFBP7 Kidney - drug effects Kidney Diseases - chemically induced Kidney Diseases - urine Kidney injury KIM-1 Male Middle Aged Occupational Exposure - adverse effects Surface-Active Agents - adverse effects Surface-Active Agents - toxicity TIMP2
Title	Exploring the link: DNA methylation and kidney injury markers in farmers exposed to glyphosate-surfactant herbicides
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