Macrophage-derived CCL1 targets CCR8 receptor in hepatic stellate cells to promote liver fibrosis through JAk/STAT pathway - Diao, Shaoxi; Li, Liangyun; Zhang, Jintong; Ji, Minglu; Sun, Lijiao; Shen, Wenwen; Wu, Shuai; Chen, Zixiang; Huang, Cheng; Li, Jun (Biochemical pharmacology, 2025)
Keywords: Animals; Apoptosis; C-C motif chemokine ligand 1; C-C motif chemokine receptor 8; Chemokine CCL1 - metabolism; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Hepatic Stellate Cells - pathology; Humans; JAK/STAT pathway; Janus Kinases - metabolism; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver fibrosis; Macrophages - metabolism; Male; Mice; Mice, Inbred C57BL; Receptors, CCR8 - genetics; Receptors, CCR8 - metabolism; Signal Transduction - physiology; STAT Transcription Factors - metabolism; C-C motif chemokine ligand 1; DMSO; JAK/STAT pathway; ALT; ddH2O; Liver fibrosis; LPS; BSA; DMEM; α-SMA; 7-AAD; min; FBS; CCR8; HSC; CCL1; cDNA; TEMED; RT-qPCR; PBS; AST; SDS; TBS; IL-4; TBST; siRNA; DEPC; M−CSF; EDTA; IL-1β; NASH; PVDF; COL.I; ECM; rpm; PMSF; HBSS; C-C motif chemokine receptor 8; mL; Apoptosis