Inhibition of matrix metalloproteases by a chemical cross-linker to halt the corneal degradation in keratoconus - Gopalakrishnan, Adhithya Subramanian; Sirajudeen, Sumaiya; Banu, Nasrin; Nunes, Jessica; Rajendran, Divya T.; Yadav, Seema; Prajna, Namperumalsamy Venkatesh; Williams, Rachel; Kuppamuthu, Dharmalingam; Giridhara Gopalan, Ramprasad Obula (Experimental eye research, 2025)
Keywords: Carbodiimide chemistry; Carbodiimides - pharmacology; Cells, Cultured; Chemical cross-linker; Collagen; Collagen - metabolism; Cornea; Cornea - drug effects; Corneal stiffening; Corneal Stroma - drug effects; Corneal Stroma - metabolism; Corneal Stroma - ultrastructure; Cross-Linking Reagents - pharmacology; Epithelium, Corneal - drug effects; Epithelium, Corneal - enzymology; Humans; Keratoconus; Keratoconus - drug therapy; Keratoconus - enzymology; Keratoconus - metabolism; Keratoconus - pathology; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Matrix Metalloproteinase Inhibitors - pharmacology; Matrix Metalloproteinases - metabolism; Metalloproteases; Microscopy, Electron, Transmission; Photosensitizing Agents - pharmacology; Riboflavin - pharmacology; Riboflavin - therapeutic use; Ultraviolet Rays; Metalloproteases; Corneal stiffening; Cornea; Keratoconus; Collagen; Carbodiimide chemistry; Chemical cross-linker