Recent Research Trends of Two‐Photon Photosensitizer for Simultaneous Imaging and Photodynamic Therapy
Imaging and photodynamic therapy through two‐photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption by the tissue. It is the best solution that can complement the shortcomings of conventional photodynamic therapy. In addition, auto‐fluorescen...
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Published in | Bulletin of the Korean Chemical Society Vol. 42; no. 9; pp. 1184 - 1190 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
Wiley‐VCH Verlag GmbH & Co. KGaA
01.09.2021
대한화학회 |
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Online Access | Get full text |
ISSN | 1229-5949 0253-2964 1229-5949 |
DOI | 10.1002/bkcs.12354 |
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Abstract | Imaging and photodynamic therapy through two‐photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption by the tissue. It is the best solution that can complement the shortcomings of conventional photodynamic therapy. In addition, auto‐fluorescence can be minimized, and damage to normal cells can be avoided through spatial and temporal control. To maximize the image realization and the effect of treatment, a single photosensitizer with high fluorescence quantum yields, two‐photon absorption value, and good 1O2 or reactive oxygen species production performance must be developed. Therefore, recent research related to this topic is summarized. In addition, two‐photon photosensitizers that approach selective imaging and treatment for target diseases and future challenges were discussed.
Imaging and photodynamic therapy through two‐photon excitation can be applied deep inside of tissue, and it is the best solution to compensate for the limitation of conventional photodynamic therapy. To maximize the image realization and the effect of therapy, a photosensitizer with high value of two‐photon absorption cross sections, fluorescence quantum yields, and good 1O2 or reactive oxygen species generation yield must be developed. |
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AbstractList | Imaging and photodynamic therapy through two-photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption by the tissue. It is the best solution that can complement the shortcomings of conventional photodynamic therapy. In addition, auto-fluorescence can be minimized, and damage to normal cells can be avoided through spatial and temporal control. To maximize the image realization and the effect of treatment, a single photosensitizer with high fluorescence quantum yields, two-photon absorption value, and good 1 O2 or reactive oxygen species production performance must be developed. Therefore, recent research related to this topic is summarized. In addition, two-photon photosensitizers that approach selective imaging and treatment for target diseases and future challenges were discussed. KCI Citation Count: 6 Imaging and photodynamic therapy through two‐photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption by the tissue. It is the best solution that can complement the shortcomings of conventional photodynamic therapy. In addition, auto‐fluorescence can be minimized, and damage to normal cells can be avoided through spatial and temporal control. To maximize the image realization and the effect of treatment, a single photosensitizer with high fluorescence quantum yields, two‐photon absorption value, and good 1 O 2 or reactive oxygen species production performance must be developed. Therefore, recent research related to this topic is summarized. In addition, two‐photon photosensitizers that approach selective imaging and treatment for target diseases and future challenges were discussed. Imaging and photodynamic therapy through two‐photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption by the tissue. It is the best solution that can complement the shortcomings of conventional photodynamic therapy. In addition, auto‐fluorescence can be minimized, and damage to normal cells can be avoided through spatial and temporal control. To maximize the image realization and the effect of treatment, a single photosensitizer with high fluorescence quantum yields, two‐photon absorption value, and good 1O2 or reactive oxygen species production performance must be developed. Therefore, recent research related to this topic is summarized. In addition, two‐photon photosensitizers that approach selective imaging and treatment for target diseases and future challenges were discussed. Imaging and photodynamic therapy through two‐photon excitation can be applied deep inside of tissue, and it is the best solution to compensate for the limitation of conventional photodynamic therapy. To maximize the image realization and the effect of therapy, a photosensitizer with high value of two‐photon absorption cross sections, fluorescence quantum yields, and good 1O2 or reactive oxygen species generation yield must be developed. |
Author | Lee, Hyo Won Lee, Dong Joon Lim, Chang Su |
Author_xml | – sequence: 1 givenname: Hyo Won surname: Lee fullname: Lee, Hyo Won organization: Ajou University – sequence: 2 givenname: Dong Joon surname: Lee fullname: Lee, Dong Joon organization: Ajou University – sequence: 3 givenname: Chang Su surname: Lim fullname: Lim, Chang Su email: cslim8112@gmail.com organization: Ajou University |
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Snippet | Imaging and photodynamic therapy through two‐photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption... Imaging and photodynamic therapy through two-photon excitation can be applied to medical application of deep inside the tissue by minimizing light absorption... |
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SubjectTerms | Fluorescence imaging Photodynamic therapy Photosensitizer Theranostics Two‐photon microscopy 화학 |
Title | Recent Research Trends of Two‐Photon Photosensitizer for Simultaneous Imaging and Photodynamic Therapy |
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