Characteristics of SNPs related with high myopia traits in Chinese Han population

• Published in: Forensic science international. Genetics supplement series Vol. 6; pp. e35 - e36
• Main Authors: Xie, Mingkun, Song, Feng, Li, Jienan, Ma, Hong, Wu, Jin, Hou, Yiping
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2017
• Subjects: Forensic DNA phenotyping; High myopia; SNaPshot; SNPs; SNPs; High myopia; SNaPshot; Forensic DNA phenotyping
• ISSN: 1875-1768; 1875-175X
• DOI: 10.1016/j.fsigss.2017.09.012

High myopia, as a kind of phenotypic traits, can be used to enhance the ability of personal identification in forensic case. To elucidate single nucleotide polymorphisms (SNPs) of microRNA related with high myopia in Chinese Han population, five SNPs were investigated with 200 (100 high myopia and 100 normal subjects) unrelated individuals from Sichuan province through SNaPshot method. Two SNPs showed a significantly different (p<0.05) allele-frequency distribution between high myopia and normal subjects. There were no statistical significant differences at other three SNPs. According to this primary research, the genotype frequency for two SNPs (rs8004825 and rs12976445) did correlate with high myopia phenotype. To predict high myopia with high accuracy, more samples and genetic markers should be performed in further study.