Disturbing Effects of Chronic Low-dose 4-Nonylphenol exposing on Gonadal Weight and Reproductive Outcome over One-generation

• Published in: Balsaeng'gwa saengsig Vol. 21; no. 2; pp. 121 - 130
• Main Authors: Cha, Sunyeong, Baek, Jeong Won, Ji, Hye Jin, Choi, Jun Hee, Kim, Chaelim, Lee, Min Young, Hwang, Yeon Jeong, Yang, Eunhyeok, Lee, Sung-Ho, Jung, Hyo-il, Cheon, Yong-Pil
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국발생생물학회 01.06.2017; The Korean Society of Developmental Biology
• Subjects: Original Research Paper; 생물학; Reproduction; Nonylphenol; Sperm count; Endocrine disrupting; Chronic low-dose nonylphenol
• ISSN: 2465-9525; 2465-9541; 2465-9541
• DOI: 10.12717/DR.2017.21.2.121

4-Nonylphenol (NP) is a surfactant that is a well-known and widespread estrogenic endocrine disrupting chemical (EDC). Although it has been known that the affinity of NP to ERs is low, it has been suggested that low-dose NP has toxicity. In the present study, the endocrine disrupting effects on reproduction, and the weight of gonads, epididymis, and uterus were evaluated with the chronic lower-dose NP exposing. This study was designed by following the OECD test guideline 443 and subjected to a complete necropsy. In male, NP had an effect on the weight of the testis and epididymis in both F and F . In females, NP decreased the weight of ovary and uterus in F but not in pre-pubertal F pubs. Fertility of male and female in F or F was no related with NP administration. The number of caudal-epididymal sperm by body weight (BW) was not different between groups in both F and F . Besides, the difference of the sperm number between generations was not detected. The number of ovulated oocytes was similar between groups in F , but significantly decreased in NP 50 group of F . The litter size and sex ratios of offspring in F and F were not different. The accumulated mating rate and gestation period were not affected by the NP administration. Those results shows that chronic lower-dose NP administration has an effect of endocrine disruptor on the weight of gonads and epididymis of F and F but not in reproduction. Based on the results, it is suggested that chronic lower-dose NP exposing causes endocrine disruption in the weight of gonad and epididymis but not in the reproductive ability of next generations.