Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells
Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion. (CF), the mature fruits of L., have been used for the treatment of gastrointestinal disturbance...
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| Published in | Journal of breast cancer Vol. 20; no. 3; pp. 234 - 239 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean Breast Cancer Society
01.09.2017
한국유방암학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1738-6756 2092-9900 |
| DOI | 10.4048/jbc.2017.20.3.234 |
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| Abstract | Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion.
(CF), the mature fruits of
L., have been used for the treatment of gastrointestinal disturbance in Asia. In this study, the effect of the ethanol extract of CF (CFE) on MMP-9 activity and the invasion of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells was examined.
The cell viability was evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The expression of MMP-9 was examined by Western blotting, zymography, and real-time polymerase chain reaction. An electrophoretic mobility gel shift assay was performed to detect activator protein-1 (AP-1) DNA binding activity and cell invasiveness was measured by an
Matrigel invasion assay.
CFE significantly suppressed MMP-9 expression and activation in a dose-dependent manner. Furthermore, CFE attenuated the TPA-induced activation of AP-1.
The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C δ/p38/c-Jun N-terminal kinase/AP-1 pathway. Therefore, CFE could restrict breast cancer invasiveness owing to its ability to inhibit MMP-9 activity. |
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| AbstractList | Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion.
(CF), the mature fruits of
L., have been used for the treatment of gastrointestinal disturbance in Asia. In this study, the effect of the ethanol extract of CF (CFE) on MMP-9 activity and the invasion of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells was examined.
The cell viability was evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The expression of MMP-9 was examined by Western blotting, zymography, and real-time polymerase chain reaction. An electrophoretic mobility gel shift assay was performed to detect activator protein-1 (AP-1) DNA binding activity and cell invasiveness was measured by an
Matrigel invasion assay.
CFE significantly suppressed MMP-9 expression and activation in a dose-dependent manner. Furthermore, CFE attenuated the TPA-induced activation of AP-1.
The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C δ/p38/c-Jun N-terminal kinase/AP-1 pathway. Therefore, CFE could restrict breast cancer invasiveness owing to its ability to inhibit MMP-9 activity. Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion. Crotonis fructus (CF), the mature fruits of Croton tiglium L., have been used for the treatment of gastrointestinal disturbance in Asia. In this study, the effect of the ethanol extract of CF (CFE) on MMP-9 activity and the invasion of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells was examined.PURPOSEMetastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion. Crotonis fructus (CF), the mature fruits of Croton tiglium L., have been used for the treatment of gastrointestinal disturbance in Asia. In this study, the effect of the ethanol extract of CF (CFE) on MMP-9 activity and the invasion of 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells was examined.The cell viability was evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The expression of MMP-9 was examined by Western blotting, zymography, and real-time polymerase chain reaction. An electrophoretic mobility gel shift assay was performed to detect activator protein-1 (AP-1) DNA binding activity and cell invasiveness was measured by an in vitro Matrigel invasion assay.METHODSThe cell viability was evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The expression of MMP-9 was examined by Western blotting, zymography, and real-time polymerase chain reaction. An electrophoretic mobility gel shift assay was performed to detect activator protein-1 (AP-1) DNA binding activity and cell invasiveness was measured by an in vitro Matrigel invasion assay.CFE significantly suppressed MMP-9 expression and activation in a dose-dependent manner. Furthermore, CFE attenuated the TPA-induced activation of AP-1.RESULTSCFE significantly suppressed MMP-9 expression and activation in a dose-dependent manner. Furthermore, CFE attenuated the TPA-induced activation of AP-1.The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C δ/p38/c-Jun N-terminal kinase/AP-1 pathway. Therefore, CFE could restrict breast cancer invasiveness owing to its ability to inhibit MMP-9 activity.CONCLUSIONThe results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C δ/p38/c-Jun N-terminal kinase/AP-1 pathway. Therefore, CFE could restrict breast cancer invasiveness owing to its ability to inhibit MMP-9 activity. Purpose: Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP- 9) is essential in metastatic cancers owing to its major role in cancer cell invasion. Crotonis fructus (CF), the mature fruits of Croton tiglium L., have been used for the treatment of gastrointestinal disturbance in Asia. In this study, the effect of the ethanol extract of CF (CFE) on MMP-9 activity and the invasion of 12-Otetradecanoylphorbol- 13-acetate (TPA)-treated MCF-7 cells was examined. Methods: The cell viability was evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The expression of MMP-9 was examined by Western blotting, zymography, and real-time polymerase chain reaction. An electrophoretic mobility gel shift assay was performed to detect activator protein-1 (AP-1) DNA binding activity and cell invasiveness was measured by an in vitro Matrigel invasion assay. Results: CFE significantly suppressed MMP-9 expression and activation in a dose-dependent manner. Furthermore, CFE attenuated the TPA-induced activation of AP-1. Conclusion: The results indicated that the inhibitory effects of CFE against TPAinduced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C δ/p38/c-Jun N-terminal kinase/ AP-1 pathway. Therefore, CFE could restrict breast cancer invasiveness owing to its ability to inhibit MMP-9 activity. KCI Citation Count: 4 |
| Author | Ryu, Do-Gon Jung, Sung Hoo Lee, Guem-San Noh, Eun-Mi Youn, Hyun Jo Lee, Young-Rae Song, Hyun-Kyung Park, Sueng Hyuk Kwon, Kang-Beom Kim, Jeong-Mi |
| AuthorAffiliation | 3 Department of Korean Physiology, Wonkwang University School of Korean Medicine, Iksan, Korea 6 Integrated Omics Institute, Wonkwang University, Iksan, Korea 1 Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Korea 4 Department of Surgery, Biomedical Research Institute of Chonbuk National University Hospital, Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, Korea 5 Department of Oral Biochemistry and Institute of Biomaterials-Implant, Wonkwang University School of Dentistry, Iksan, Korea 2 Department of Herbology, Wonkwang University School of Korean Medicine, Iksan, Korea |
| AuthorAffiliation_xml | – name: 2 Department of Herbology, Wonkwang University School of Korean Medicine, Iksan, Korea – name: 4 Department of Surgery, Biomedical Research Institute of Chonbuk National University Hospital, Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, Korea – name: 1 Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Korea – name: 5 Department of Oral Biochemistry and Institute of Biomaterials-Implant, Wonkwang University School of Dentistry, Iksan, Korea – name: 6 Integrated Omics Institute, Wonkwang University, Iksan, Korea – name: 3 Department of Korean Physiology, Wonkwang University School of Korean Medicine, Iksan, Korea |
| Author_xml | – sequence: 1 givenname: Hyun-Kyung surname: Song fullname: Song, Hyun-Kyung organization: Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Korea – sequence: 2 givenname: Guem-San surname: Lee fullname: Lee, Guem-San organization: Department of Herbology, Wonkwang University School of Korean Medicine, Iksan, Korea – sequence: 3 givenname: Sueng Hyuk surname: Park fullname: Park, Sueng Hyuk organization: Department of Korean Physiology, Wonkwang University School of Korean Medicine, Iksan, Korea – sequence: 4 givenname: Eun-Mi surname: Noh fullname: Noh, Eun-Mi organization: Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Korea – sequence: 5 givenname: Jeong-Mi surname: Kim fullname: Kim, Jeong-Mi organization: Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Korea – sequence: 6 givenname: Do-Gon surname: Ryu fullname: Ryu, Do-Gon organization: Department of Korean Physiology, Wonkwang University School of Korean Medicine, Iksan, Korea – sequence: 7 givenname: Sung Hoo surname: Jung fullname: Jung, Sung Hoo organization: Department of Surgery, Biomedical Research Institute of Chonbuk National University Hospital, Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, Korea – sequence: 8 givenname: Hyun Jo surname: Youn fullname: Youn, Hyun Jo organization: Department of Surgery, Biomedical Research Institute of Chonbuk National University Hospital, Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, Korea – sequence: 9 givenname: Young-Rae surname: Lee fullname: Lee, Young-Rae organization: Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Korea., Department of Oral Biochemistry and Institute of Biomaterials-Implant, Wonkwang University School of Dentistry, Iksan, Korea., Integrated Omics Institute, Wonkwang University, Iksan, Korea – sequence: 10 givenname: Kang-Beom surname: Kwon fullname: Kwon, Kang-Beom organization: Center for Metabolic Function Regulation, Wonkwang University School of Medicine, Iksan, Korea., Department of Korean Physiology, Wonkwang University School of Korean Medicine, Iksan, Korea |
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| Cites_doi | 10.1002/mc.20398 10.1159/000468614 10.1038/nrd2372 10.1007/BF02974234 10.1155/2014/780385 10.3748/wjg.v8.i1.103 10.1074/jbc.M413985200 10.1111/j.1365-2559.2007.02615.x 10.1016/S0955-0674(97)80068-3 10.1074/jbc.M002349200 10.1093/jnci/89.17.1260 10.1096/fasebj.5.8.1850705 10.1254/jphs.94.60 10.1016/j.phymed.2012.07.002 10.1046/j.1440-1827.2002.01343.x 10.4049/jimmunol.165.10.5788 10.1002/ijc.29210 10.1097/00006534-200001000-00039 10.1007/BF02978209 |
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| Keywords | Crotonis fructus Neoplasm invasiveness MCF-7 cells Matrix metalloproteinase 9 Transcription factor AP-1 |
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| Snippet | Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers... Purpose: Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP- 9) is essential in metastatic... |
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| Title | Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells |
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