Chronic morphine treatment induces sex- and synapse-specific cellular tolerance on thalamo-cortical mu opioid receptor signaling - Jaeckel, Elizabeth R.; Arias-Hervert, Erwin R.; Perez-Medina, Alberto L.; Schulz, Stefan; Birdsong, William T. (Journal of neurophysiology, 2024)
Keywords: Analgesics, Opioid - administration & dosage; Analgesics, Opioid - pharmacology; Animals; Drug Tolerance - physiology; Female; Gyrus Cinguli - drug effects; Gyrus Cinguli - metabolism; Gyrus Cinguli - physiology; Male; Mice; Mice, Inbred C57BL; Morphine - administration & dosage; Morphine - pharmacology; Pyramidal Cells - drug effects; Pyramidal Cells - physiology; Receptors, Opioid, mu - metabolism; Sex Characteristics; Signal Transduction - drug effects; Synapses - drug effects; Synapses - physiology; Thalamus - drug effects; Thalamus - metabolism; Thalamus - physiology; synapse; circuit: anterior cingulate cortex; tolerance; opioid; thalamus