Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB signaling pathway - Ma, Jiawei; Zhang, Hanwen; Wang, Ze; Xu, Cong; Tan, Hongye; Sun, Yun; Zheng, Rukang; Jin, Zebin; Li, Yuanyuan; Ge, Xinjiang; Wu, Yaosen; Zhou, Yifei (Journal of ethnopharmacology, 2024)
Keywords: analgesics; Animals; Anti-Inflammatory Agents - pharmacology; Apoptosis; Apoptosis - drug effects; cartilage; Cells, Cultured; Cellular Senescence - drug effects; chondrocytes; Chondrocytes - drug effects; Chondrocytes - metabolism; extracellular matrix; fluorescent antibody technique; formononetin; immunohistochemistry; inflammation; Inflammation - drug therapy; Inflammation - pathology; Inflammatory; Interleukin-1beta - metabolism; Lycopodium - chemistry; Lycopodium japonicum; Lycopodium japonicum thunb; Male; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; NF-kappa B - metabolism; Oriental traditional medicine; Osteoarthritis; Osteoarthritis - drug therapy; Osteoarthritis - pathology; pain; pharmacology; Plant Extracts - pharmacology; secretion; Senescence; Signal Transduction - drug effects; sitosterols; stigmasterol; STING; viability; Inflammatory; Lycopodium japonicum thunb; STING; Senescence; Osteoarthritis; Apoptosis