Palladium catalyzed tandem alkenyl- and aryl-C–N bond formation: a cascade N-annulation route to 4-, 5-, 6- and 7-chloroindoles
A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the N-nu...
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| Published in | Tetrahedron Vol. 66; no. 33; pp. 6632 - 6638 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
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Elsevier Ltd
14.08.2010
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0040-4020 1464-5416 |
| DOI | 10.1016/j.tet.2010.05.046 |
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| Abstract | A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the
N-nucleophile.
[Display omitted] |
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| AbstractList | A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared; carbamates, anilines and amines can be employed as the
N-nucleophile.
[Display omitted] A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of 1-functionalized mono-chloroindoles. 4-, 5-, 6- and 7-Chloroindoles can all be prepared: carbamates, anilines and amines can be employed as the N-nucleophile. (C) 2010 Elsevier Ltd. All rights reserved. |
| Author | Willis, Michael C. Lindon, Matthew J. Henderson, Luke C. |
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| Keywords | Amination Indole Palladium FUNCTIONALIZATION OXYGEN DIRECT ARYLATION HETEROCYCLES COUPLING REACTIONS HALOGENATED NITROGEN INDOLES |
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| Snippet | A series of trihalogenated alkenylbenzenes undergo consecutive palladium catalyzed inter- and intramolecular amination reactions to deliver a series of... |
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| SubjectTerms | Amination Chemistry Chemistry, Organic Indole Palladium Physical Sciences Science & Technology |
| Title | Palladium catalyzed tandem alkenyl- and aryl-C–N bond formation: a cascade N-annulation route to 4-, 5-, 6- and 7-chloroindoles |
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