Fusobacterium nucleatum is not significantly present in eutopic endometrium from patients with minimal-mild and moderate-severe endometriosis
To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared with controls, and assess their association with the disease. Retrospective case-control study. Ninety-two women (55 endometriosis cases and 37 controls) a...
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| Published in | Fertility and sterility |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
28.06.2025
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| ISSN | 0015-0282 1556-5653 1556-5653 |
| DOI | 10.1016/j.fertnstert.2025.06.035 |
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| Abstract | To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared with controls, and assess their association with the disease.
Retrospective case-control study.
Ninety-two women (55 endometriosis cases and 37 controls) aged 18–44 years undergoing gynecologic endoscopy for endometriosis and/or benign conditions at University of Pennsylvania, Endomarker Study (PMID: 29524590).
DNA extraction from eutopic endometrial samples using QIAamp DNA Microbiome and IndiSpin Pathogen Kits. Quantification of Fusobacterium spp. and F. nucleatum by quantitative PCR using genus- and species-specific primers.
Relative abundance of Fusobacterium spp. and F. nucleatum in cases vs. controls, analyzed using the ΔCt method.
No significant difference in Fusobacterium spp. or F. nucleatum abundance was observed between cases and controls (P = .258 for genus-specific primers, P = .738 for species-specific primers). Subgroup analysis by disease severity (minimal-mild: n = 42; moderate-severe: n = 13) also showed no significant differences (Fusobacterium spp.: P = .1465; F. nucleatum: P = .2936).
Fusobacterium spp. is not differentially present in eutopic endometrium of women with endometriosis, regardless of disease severity according to revised American Society for Reproductive Medicine classification. This contrasts with prior findings in eutopic endometrium in patients with ovarian endometriosis, suggesting that Fusobacterium has limited diagnostic or prognostic value in endometriosis. |
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| AbstractList | To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared with controls, and assess their association with the disease.
Retrospective case-control study.
Ninety-two women (55 endometriosis cases and 37 controls) aged 18-44 years undergoing gynecologic endoscopy for endometriosis and/or benign conditions at University of Pennsylvania, Endomarker Study (PMID: 29524590).
DNA extraction from eutopic endometrial samples using QIAamp DNA Microbiome and IndiSpin Pathogen Kits. Quantification of Fusobacterium spp. and F. nucleatum by quantitative PCR using genus- and species-specific primers.
Relative abundance of Fusobacterium spp. and F. nucleatum in cases vs. controls, analyzed using the ΔCt method.
No significant difference in Fusobacterium spp. or F. nucleatum abundance was observed between cases and controls (P = .258 for genus-specific primers, P = .738 for species-specific primers). Subgroup analysis by disease severity (minimal-mild: n = 42; moderate-severe: n = 13) also showed no significant differences (Fusobacterium spp.: P = .1465; F. nucleatum: P = .2936).
Fusobacterium spp. is not differentially present in eutopic endometrium of women with endometriosis, regardless of disease severity according to revised American Society for Reproductive Medicine classification. This contrasts with prior findings in eutopic endometrium in patients with ovarian endometriosis, suggesting that Fusobacterium has limited diagnostic or prognostic value in endometriosis. To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared to controls, and assess their association with the disease.OBJECTIVETo evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared to controls, and assess their association with the disease.Retrospective case-control study.DESIGNRetrospective case-control study.Ninety-two women (55 endometriosis cases and 37 controls) aged 18-44 undergoing gynecologic endoscopy for endometriosis and/or benign conditions at University of Pennsylvania, Endomarker Study (PMID: 29524590).SUBJECTSNinety-two women (55 endometriosis cases and 37 controls) aged 18-44 undergoing gynecologic endoscopy for endometriosis and/or benign conditions at University of Pennsylvania, Endomarker Study (PMID: 29524590).DNA extraction from eutopic endometrial samples using QIAamp DNA Microbiome and IndiSpin® Pathogen Kits. Quantification of Fusobacterium spp. and F. nucleatum by quantitative PCR using genus- and species-specific primers.EXPOSUREDNA extraction from eutopic endometrial samples using QIAamp DNA Microbiome and IndiSpin® Pathogen Kits. Quantification of Fusobacterium spp. and F. nucleatum by quantitative PCR using genus- and species-specific primers.Relative abundance of Fusobacterium spp. and F. nucleatum in cases versus controls, analyzed using the ΔCt method.MAIN OUTCOME MEASURE(S)Relative abundance of Fusobacterium spp. and F. nucleatum in cases versus controls, analyzed using the ΔCt method.No significant difference in Fusobacterium spp. or F. nucleatum abundance was observed between cases and controls (P = 0.258 for genus-specific primers, P = 0.738 for species-specific primers). Subgroup analysis by disease severity (minimal-mild: n=42; moderate-severe: n=13) also showed no significant differences (Fusobacterium spp.: P = 0.1465; F. nucleatum: P = 0.2936).RESULTSNo significant difference in Fusobacterium spp. or F. nucleatum abundance was observed between cases and controls (P = 0.258 for genus-specific primers, P = 0.738 for species-specific primers). Subgroup analysis by disease severity (minimal-mild: n=42; moderate-severe: n=13) also showed no significant differences (Fusobacterium spp.: P = 0.1465; F. nucleatum: P = 0.2936).Fusobacterium spp. is not differentially present in eutopic endometrium of women with endometriosis, regardless of disease severity according to rASRM classification. This contrasts with prior findings in eutopic endometrium in patients with ovarian endometriosis, suggesting that Fusobacterium has limited diagnostic or prognostic value in endometriosis.CONCLUSIONFusobacterium spp. is not differentially present in eutopic endometrium of women with endometriosis, regardless of disease severity according to rASRM classification. This contrasts with prior findings in eutopic endometrium in patients with ovarian endometriosis, suggesting that Fusobacterium has limited diagnostic or prognostic value in endometriosis. |
| Author | Legro, Richard S. Vilella, Felipe Simon, Carlos Moreno, Inmaculada Graciano-España, María Carmen Rush, Margaret A. Barnhart, Kurt Arenas-Barrero, Marta Fernández-Sánchez, Manuel Thomas, Tracey R. Gonzalez-Monfort, Marta |
| Author_xml | – sequence: 1 givenname: María Carmen surname: Graciano-España fullname: Graciano-España, María Carmen organization: Carlos Simon Foundation, Valencia, Spain – sequence: 2 givenname: Kurt surname: Barnhart fullname: Barnhart, Kurt organization: Penn Medicine Women's Health Clinical Research Center, University of Pennsylvania, Philadelphia, Pennsylvania – sequence: 3 givenname: Marta surname: Gonzalez-Monfort fullname: Gonzalez-Monfort, Marta organization: Carlos Simon Foundation, Valencia, Spain – sequence: 4 givenname: Marta surname: Arenas-Barrero fullname: Arenas-Barrero, Marta organization: Carlos Simon Foundation, Valencia, Spain – sequence: 5 givenname: Richard S. surname: Legro fullname: Legro, Richard S. organization: Penn State College of Medicine, Research, Hershey, Pennsylvania – sequence: 6 givenname: Tracey R. surname: Thomas fullname: Thomas, Tracey R. organization: Penn Medicine Women's Health Clinical Research Center, University of Pennsylvania, Philadelphia, Pennsylvania – sequence: 7 givenname: Margaret A. surname: Rush fullname: Rush, Margaret A. organization: Penn Medicine Women's Health Clinical Research Center, University of Pennsylvania, Philadelphia, Pennsylvania – sequence: 8 givenname: Felipe surname: Vilella fullname: Vilella, Felipe organization: Carlos Simon Foundation, Valencia, Spain – sequence: 9 givenname: Manuel surname: Fernández-Sánchez fullname: Fernández-Sánchez, Manuel organization: Vida Recoletas Sevilla, Seville, Spain – sequence: 10 givenname: Carlos surname: Simon fullname: Simon, Carlos email: csimon@fundacioncarlossimon.com organization: Carlos Simon Foundation, Valencia, Spain – sequence: 11 givenname: Inmaculada orcidid: 0000-0001-6910-7509 surname: Moreno fullname: Moreno, Inmaculada email: imoreno@fundacioncarlossimon.com organization: Carlos Simon Foundation, Valencia, Spain |
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| Snippet | To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared with controls,... To evaluate the presence of Fusobacterium spp. and Fusobacterium nucleatum in eutopic endometrial samples from women with endometriosis compared to controls,... |
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| Title | Fusobacterium nucleatum is not significantly present in eutopic endometrium from patients with minimal-mild and moderate-severe endometriosis |
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