Water, Collagen, and Lipid Content in the Human Skin and Muscles Assessed with Near‐Infrared Diffuse Reflectance Spectroscopy and Multi‐Spectral Optoacoustic Tomography
Infrared spectroscopy can quantify individual body components such as lipids, water, and proteins, but extending it to a comprehensive assessment of overall body composition is hampered by high variability and optical heterogeneity of biological tissues. Here, a theoretical and experimental strategy...
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| Published in | Advanced science p. e05619 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
13.08.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 2198-3844 2198-3844 |
| DOI | 10.1002/advs.202505619 |
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| Abstract | Infrared spectroscopy can quantify individual body components such as lipids, water, and proteins, but extending it to a comprehensive assessment of overall body composition is hampered by high variability and optical heterogeneity of biological tissues. Here, a theoretical and experimental strategy merging multi‐spectral optoacoustic tomography (MSOT) and diffuse reflectance spectroscopy (DRS) is introduced to characterize skin and subcutaneous tissue composition in the near‐infrared range. Water, lipids, and collagen exhibit distinct absorption peaks, with lipids demonstrating significantly higher absorption than collagen at comparable mass concentrations. Diminished lipid absorption in subjects with thin hypodermis allows the DRS method to detect distinct collagen band at 910 nm, whose magnitude correlates with the muscle mass, as confirmed by bioimpedance analysis. Conversely, strong lipid peak at 930 nm in subjects with pronounced hypodermis overshadows collagen signals by an order of magnitude, making DRS characterization insufficient. MSOT overcomes this limitation by offering high‐resolution depth‐resolved 3D imaging to accurately delineate the dermis, hypodermis, and muscle layers in vivo and quantify each chromophore's contribution individually. The findings demonstrate the complementary capabilities of MSOT and DRS for molecularly specific, noninvasive body composition analysis, potentially enhancing diagnostic approaches for a number of conditions, such as obesity and sarcopenia. |
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| AbstractList | Infrared spectroscopy can quantify individual body components such as lipids, water, and proteins, but extending it to a comprehensive assessment of overall body composition is hampered by high variability and optical heterogeneity of biological tissues. Here, a theoretical and experimental strategy merging multi-spectral optoacoustic tomography (MSOT) and diffuse reflectance spectroscopy (DRS) is introduced to characterize skin and subcutaneous tissue composition in the near-infrared range. Water, lipids, and collagen exhibit distinct absorption peaks, with lipids demonstrating significantly higher absorption than collagen at comparable mass concentrations. Diminished lipid absorption in subjects with thin hypodermis allows the DRS method to detect distinct collagen band at 910 nm, whose magnitude correlates with the muscle mass, as confirmed by bioimpedance analysis. Conversely, strong lipid peak at 930 nm in subjects with pronounced hypodermis overshadows collagen signals by an order of magnitude, making DRS characterization insufficient. MSOT overcomes this limitation by offering high-resolution depth-resolved 3D imaging to accurately delineate the dermis, hypodermis, and muscle layers in vivo and quantify each chromophore's contribution individually. The findings demonstrate the complementary capabilities of MSOT and DRS for molecularly specific, noninvasive body composition analysis, potentially enhancing diagnostic approaches for a number of conditions, such as obesity and sarcopenia. Infrared spectroscopy can quantify individual body components such as lipids, water, and proteins, but extending it to a comprehensive assessment of overall body composition is hampered by high variability and optical heterogeneity of biological tissues. Here, a theoretical and experimental strategy merging multi-spectral optoacoustic tomography (MSOT) and diffuse reflectance spectroscopy (DRS) is introduced to characterize skin and subcutaneous tissue composition in the near-infrared range. Water, lipids, and collagen exhibit distinct absorption peaks, with lipids demonstrating significantly higher absorption than collagen at comparable mass concentrations. Diminished lipid absorption in subjects with thin hypodermis allows the DRS method to detect distinct collagen band at 910 nm, whose magnitude correlates with the muscle mass, as confirmed by bioimpedance analysis. Conversely, strong lipid peak at 930 nm in subjects with pronounced hypodermis overshadows collagen signals by an order of magnitude, making DRS characterization insufficient. MSOT overcomes this limitation by offering high-resolution depth-resolved 3D imaging to accurately delineate the dermis, hypodermis, and muscle layers in vivo and quantify each chromophore's contribution individually. The findings demonstrate the complementary capabilities of MSOT and DRS for molecularly specific, noninvasive body composition analysis, potentially enhancing diagnostic approaches for a number of conditions, such as obesity and sarcopenia.Infrared spectroscopy can quantify individual body components such as lipids, water, and proteins, but extending it to a comprehensive assessment of overall body composition is hampered by high variability and optical heterogeneity of biological tissues. Here, a theoretical and experimental strategy merging multi-spectral optoacoustic tomography (MSOT) and diffuse reflectance spectroscopy (DRS) is introduced to characterize skin and subcutaneous tissue composition in the near-infrared range. Water, lipids, and collagen exhibit distinct absorption peaks, with lipids demonstrating significantly higher absorption than collagen at comparable mass concentrations. Diminished lipid absorption in subjects with thin hypodermis allows the DRS method to detect distinct collagen band at 910 nm, whose magnitude correlates with the muscle mass, as confirmed by bioimpedance analysis. Conversely, strong lipid peak at 930 nm in subjects with pronounced hypodermis overshadows collagen signals by an order of magnitude, making DRS characterization insufficient. MSOT overcomes this limitation by offering high-resolution depth-resolved 3D imaging to accurately delineate the dermis, hypodermis, and muscle layers in vivo and quantify each chromophore's contribution individually. The findings demonstrate the complementary capabilities of MSOT and DRS for molecularly specific, noninvasive body composition analysis, potentially enhancing diagnostic approaches for a number of conditions, such as obesity and sarcopenia. |
| Author | Subochev, Pavel Fadeev, Nikolay Urusova, Liliya Shirshin, Evgeny Davydov, Denis Razansky, Daniel Filippov, Ivan Mokrysheva, Natalia Kurnikov, Alexey Budylin, Gleb |
| Author_xml | – sequence: 1 givenname: Denis surname: Davydov fullname: Davydov, Denis organization: Laboratory of Clinical Biophotonics Institute for Regenerative Medicine I.M. Sechenov First Moscow State Medical University Moscow 119048 Russia, Medical research and Educational Institute Lomonosov Moscow State University Moscow 119991 Russia – sequence: 2 givenname: Alexey surname: Kurnikov fullname: Kurnikov, Alexey organization: Laboratory of ultrasound and optoacoustic diagnostics Division of radiophysics methods in medicine A.V. Gaponov‐Grekhov Institute of Applied Physics RAS Nizhny Novgorod 603950 Russia – sequence: 3 givenname: Pavel surname: Subochev fullname: Subochev, Pavel organization: Laboratory of ultrasound and optoacoustic diagnostics Division of radiophysics methods in medicine A.V. Gaponov‐Grekhov Institute of Applied Physics RAS Nizhny Novgorod 603950 Russia – sequence: 4 givenname: Gleb surname: Budylin fullname: Budylin, Gleb organization: Laboratory of Clinical Biophotonics Institute for Regenerative Medicine I.M. Sechenov First Moscow State Medical University Moscow 119048 Russia – sequence: 5 givenname: Nikolay surname: Fadeev fullname: Fadeev, Nikolay organization: Faculty of Рhysics M.V. Lomonosov Moscow State University Moscow 119991 Russia – sequence: 6 givenname: Ivan surname: Filippov fullname: Filippov, Ivan organization: Faculty of Рhysics M.V. Lomonosov Moscow State University Moscow 119991 Russia – sequence: 7 givenname: Natalia surname: Mokrysheva fullname: Mokrysheva, Natalia organization: Laboratory of Endocrine Biophotonics Endocrinology Research Center Moscow 117292 Russia – sequence: 8 givenname: Liliya surname: Urusova fullname: Urusova, Liliya organization: Laboratory of Endocrine Biophotonics Endocrinology Research Center Moscow 117292 Russia – sequence: 9 givenname: Daniel surname: Razansky fullname: Razansky, Daniel organization: Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology Faculty of Medicine University of Zurich Zurich 8057 Switzerland, Institute for Biomedical Engineering Department of Information Technology and Electrical Engineering ETH Zurich Zurich 8093 Switzerland – sequence: 10 givenname: Evgeny surname: Shirshin fullname: Shirshin, Evgeny organization: Faculty of Рhysics M.V. Lomonosov Moscow State University Moscow 119991 Russia, Laboratory of Endocrine Biophotonics Endocrinology Research Center Moscow 117292 Russia |
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| Keywords | collagen lipids diffuse reflectance spectroscopy muscles multi‐spectral optoacoustic tomography |
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| Title | Water, Collagen, and Lipid Content in the Human Skin and Muscles Assessed with Near‐Infrared Diffuse Reflectance Spectroscopy and Multi‐Spectral Optoacoustic Tomography |
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