The Occurrence of Clostridium difficile Toxin in Ulcerative Colitis
The occurrence of Clostridium dificile toxin in feces was studied in 17 cases of ulcerative colitis (mild, 5 ; moderate, 11 ; severe, 1) (initial attack, 1 ; relapsing-remitting, 15 ; chronic persistent, 1). Toxin was demonstrated in only two of the 17 cases (11.8%). In one of these two cases, antib...
Saved in:
| Published in | Nippon Daicho Komonbyo Gakkai Zasshi Vol. 41; no. 6; pp. 860 - 863 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
The Japan Society of Coloproctology
1988
|
| Online Access | Get full text |
| ISSN | 0047-1801 1882-9619 1882-9619 |
| DOI | 10.3862/jcoloproctology.41.860 |
Cover
| Abstract | The occurrence of Clostridium dificile toxin in feces was studied in 17 cases of ulcerative colitis (mild, 5 ; moderate, 11 ; severe, 1) (initial attack, 1 ; relapsing-remitting, 15 ; chronic persistent, 1). Toxin was demonstrated in only two of the 17 cases (11.8%). In one of these two cases, antibiotics had been administered beforehand and the diagnosis made was ulcerative colitis with antibiotic-associated pseudomembranous colitis. In the other case, toxin was positive only on admission and became negative three days later without treatment. There was no correlation between the presence of the toxin and the severity of ulectative colitis. Since toxin was negative in all of 11 cases treated with sulfasalazine, administration of this agent was unrelated to the presence of the toxin. Our results suggest that Clostridium difficite toxin is not related to the onset or relapse of ulcerative colitis. |
|---|---|
| AbstractList | The occurrence of Clostridium dificile toxin in feces was studied in 17 cases of ulcerative colitis (mild, 5 ; moderate, 11 ; severe, 1) (initial attack, 1 ; relapsing-remitting, 15 ; chronic persistent, 1). Toxin was demonstrated in only two of the 17 cases (11.8%). In one of these two cases, antibiotics had been administered beforehand and the diagnosis made was ulcerative colitis with antibiotic-associated pseudomembranous colitis. In the other case, toxin was positive only on admission and became negative three days later without treatment. There was no correlation between the presence of the toxin and the severity of ulectative colitis. Since toxin was negative in all of 11 cases treated with sulfasalazine, administration of this agent was unrelated to the presence of the toxin. Our results suggest that Clostridium difficite toxin is not related to the onset or relapse of ulcerative colitis. |
| Author | Arakawa, H. Masamune, O. Kodama, K. Igarashi, K. Horie, Y. Iizuka, M. Tsurui, N. Chiba, M. |
| Author_xml | – sequence: 1 fullname: Iizuka, M. organization: The First Department of Internal Medicine, Akita University School of Medicine – sequence: 1 fullname: Igarashi, K. organization: The First Department of Internal Medicine, Akita University School of Medicine – sequence: 1 fullname: Chiba, M. organization: The First Department of Internal Medicine, Akita University School of Medicine – sequence: 1 fullname: Kodama, K. organization: The First Department of Internal Medicine, Akita University School of Medicine – sequence: 1 fullname: Tsurui, N. organization: The First Department of Internal Medicine, Akita University School of Medicine – sequence: 1 fullname: Horie, Y. organization: The First Department of Internal Medicine, Akita University School of Medicine – sequence: 1 fullname: Masamune, O. organization: The First Department of Internal Medicine, Akita University School of Medicine – sequence: 1 fullname: Arakawa, H. organization: The First Department of Internal Medicine, Akita University School of Medicine |
| BookMark | eNqN0E1uwjAQBWCrolIp5QpVLhBqO8FxllXUPwmJDawjZzwGIxMjO7Tl9g0KYsGq0mjeZr5ZvEcyan2LhDwzOsuk4C878M4fgoeuz81plrOZFPSOjJmUPC0FK0dkTGlepExS9kCmMdqGUp7LXMznY1KttpgsAY4hYAuYeJNUzscuWG2P-0RbYyxYh8nK_9o26WftAIPq7DcmlXe2s_GJ3BvlIk4vOSHr97dV9Zkulh9f1esiBV5ymgqqVSMMzblShVS8wQYFMCOZBlmUkmcMoeSgtC4z3chCM5kbpRtuCsgakU1IMfw9tgd1-lHO1Ydg9yqcakbrcx31TR11zuq-jl6KQULwMQY0_4fLAe5ipzZ4ZSp0FhzeMlaK4kzFsPoP10vYqlBjm_0BxkKMpw |
| ContentType | Journal Article |
| Copyright | The Japan Society of Coloproctology |
| Copyright_xml | – notice: The Japan Society of Coloproctology |
| DBID | AAYXX CITATION ADTOC UNPAY |
| DOI | 10.3862/jcoloproctology.41.860 |
| DatabaseName | CrossRef Unpaywall for CDI: Periodical Content Unpaywall |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1882-9619 |
| EndPage | 863 |
| ExternalDocumentID | 10.3862/jcoloproctology.41.860 10_3862_jcoloproctology_41_860 article_jcoloproctology1967_41_6_41_6_860_article_char_en |
| GroupedDBID | 123 2WC ABDBF ALMA_UNASSIGNED_HOLDINGS CS3 F5P JSF KQ8 OK1 RJT AAYXX CITATION ADTOC UNPAY |
| ID | FETCH-LOGICAL-c2920-60dab6f042aa78a2bebe6c1f81dc8798231ec92cadd93db87d184fadb2f7c3b63 |
| IEDL.DBID | UNPAY |
| ISSN | 0047-1801 1882-9619 |
| IngestDate | Tue Aug 19 23:20:56 EDT 2025 Tue Jul 01 03:53:55 EDT 2025 Wed Sep 03 06:31:28 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English Japanese |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c2920-60dab6f042aa78a2bebe6c1f81dc8798231ec92cadd93db87d184fadb2f7c3b63 |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://www.jstage.jst.go.jp/article/jcoloproctology1967/41/6/41_6_860/_pdf |
| PageCount | 4 |
| ParticipantIDs | unpaywall_primary_10_3862_jcoloproctology_41_860 crossref_primary_10_3862_jcoloproctology_41_860 jstage_primary_article_jcoloproctology1967_41_6_41_6_860_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 1900 |
| PublicationDate | 1988 1988-00-00 |
| PublicationDateYYYYMMDD | 1988-01-01 |
| PublicationDate_xml | – year: 1988 text: 1988 |
| PublicationDecade | 1980 |
| PublicationTitle | Nippon Daicho Komonbyo Gakkai Zasshi |
| PublicationTitleAlternate | Nippon Daicho Komonbyo Gakkai Zasshi |
| PublicationYear | 1988 |
| Publisher | The Japan Society of Coloproctology |
| Publisher_xml | – name: The Japan Society of Coloproctology |
| References | 10) Keighley MRB, Young D, Johnson M, et al : Clostridium difficle toxin in acute dirrhoea complicating inflammatory bowel disease. Gut 23 : 410-414, 1982 16) Truelove SC, Witts IJ : Cortisone in ulcerative colitis. Report on therapeutic trial. Br Med J 2, 375, 1953 19) Hall IC, O'Toole E : Intestinal flora in new-born infants with a description of a new pathogenic anaerobe Bacillus difficile.Am J Dis Child 49 : 309-402, 1935 21) Banno Y, Kobayashi T, Kono H, et al : Biochemical characterization and biologic action of two toxins (D-1 and D-2) from Clostridium difficle. Rev Infect Dis 6 : S11-S20, 1984 5) Trnka YM, Lamont JT : Association of clostridium difficile toxin with symptomatic relapse of chronic inflammatory bowel disease. Gastroenterology 80 : 693-696, 1981 6) Bolton RP, Sherriff RJ, Read AE : Clostridium difficile associated diarrhea : a role in inflammatory bowel disease? Lancet I 383-384, 1980 9) Meyers S, Mayer L, Bottone E, et al : Occurrence of Clostridium difficle toxin during the course of inflammatory bowel disease.Gastroenterology 80 : 697-700, 1981 14) 小島孝雄,中村俊之,吉田貴,ほか:糞便からclostridium difficile toxinを検出した潰瘍性大腸炎の一例.日消病会誌78 : 1298-1302, 1981 4) Lamont JT, Trnka YM : Therapeutic implications of Clostridium difficile toxin during relapse of chronic inflammatory bowel disease. Lancet I : 381-383, 1980 13) 福田博英,井出孝,市村経敏ほか:Clostridium difficleを検出した13症例の臨床的検討.日消病会誌80 : 954-962, 1981 2) Bartlett JG, Moon N, Chang TW, et al:Role of clostridium difficile in antibiotic-associated pseudomembranous colitis. Gastro-enterology 75 : 778-782, 1978 20) Sullivian NM, Pellet S, Wilkins TD :Purification and characterization of toxin A and B of Clostridium difficile. Infect Immunity 35 : 1032-1040, 1982 7) Greenfield C, Ramirez JRA, Pounder RE,et al : Clostridium difficile and inflammatory bowel disease. Gut 24 : 713-717, 1983 1) Larson HE, Price AB, Honour P : Clostridium difficile and etiology of pseudomembranous colitis. Lancet I : 1063-1066, 1978 17)古川清憲,山口裕通,足立憲治,ほか;抗生物質におけるClostridium difficle toxinの簡易同定法.最新医38 : 2475-2480, 1983 12) Hyams JS, McLaughlin JC : Lack of relationship between Clostridium difficle toxin and inflammatory bowel disease in children. J Clin Gastroenterol 7 : 387-390, 1985 3) Bartlett JG, Chang TW, Gurwith M, et al : Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 298 : 531-534, 1978 11) Rolny P, Järnerot G, Möllby R : Occurrence of Clostridium difficle toxin in inflammatory bowel disease. Scand J Gastroenterol 18 : 61-64, 1983 18)稲松孝思:Clostridium difficleの毒素迅速同定.目医師会誌96 : 1896-1897, 1986 8) Lee DKF, Cooper BT, Barbezat GO, et al : Clostridium difficle toxin in chronic idiopathic colitis. NZ Med J 99 : 620-622, 1986 15) 千葉満郎,長沼敏雄,後藤充男,ほか:抗生物質投与後偽膜性大腸炎を合併した潰瘍性大腸炎の1例―Basedow病の合併についての考察も含めて―.Gastroenterol Endosc 27 : 2797-2805, 1985 |
| References_xml | – reference: 15) 千葉満郎,長沼敏雄,後藤充男,ほか:抗生物質投与後偽膜性大腸炎を合併した潰瘍性大腸炎の1例―Basedow病の合併についての考察も含めて―.Gastroenterol Endosc 27 : 2797-2805, 1985 – reference: 8) Lee DKF, Cooper BT, Barbezat GO, et al : Clostridium difficle toxin in chronic idiopathic colitis. NZ Med J 99 : 620-622, 1986 – reference: 20) Sullivian NM, Pellet S, Wilkins TD :Purification and characterization of toxin A and B of Clostridium difficile. Infect Immunity 35 : 1032-1040, 1982 – reference: 7) Greenfield C, Ramirez JRA, Pounder RE,et al : Clostridium difficile and inflammatory bowel disease. Gut 24 : 713-717, 1983 – reference: 19) Hall IC, O'Toole E : Intestinal flora in new-born infants with a description of a new pathogenic anaerobe Bacillus difficile.Am J Dis Child 49 : 309-402, 1935 – reference: 14) 小島孝雄,中村俊之,吉田貴,ほか:糞便からclostridium difficile toxinを検出した潰瘍性大腸炎の一例.日消病会誌78 : 1298-1302, 1981 – reference: 5) Trnka YM, Lamont JT : Association of clostridium difficile toxin with symptomatic relapse of chronic inflammatory bowel disease. Gastroenterology 80 : 693-696, 1981 – reference: 12) Hyams JS, McLaughlin JC : Lack of relationship between Clostridium difficle toxin and inflammatory bowel disease in children. J Clin Gastroenterol 7 : 387-390, 1985 – reference: 4) Lamont JT, Trnka YM : Therapeutic implications of Clostridium difficile toxin during relapse of chronic inflammatory bowel disease. Lancet I : 381-383, 1980 – reference: 16) Truelove SC, Witts IJ : Cortisone in ulcerative colitis. Report on therapeutic trial. Br Med J 2, 375, 1953 – reference: 17)古川清憲,山口裕通,足立憲治,ほか;抗生物質におけるClostridium difficle toxinの簡易同定法.最新医38 : 2475-2480, 1983 – reference: 11) Rolny P, Järnerot G, Möllby R : Occurrence of Clostridium difficle toxin in inflammatory bowel disease. Scand J Gastroenterol 18 : 61-64, 1983 – reference: 21) Banno Y, Kobayashi T, Kono H, et al : Biochemical characterization and biologic action of two toxins (D-1 and D-2) from Clostridium difficle. Rev Infect Dis 6 : S11-S20, 1984 – reference: 3) Bartlett JG, Chang TW, Gurwith M, et al : Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med 298 : 531-534, 1978 – reference: 10) Keighley MRB, Young D, Johnson M, et al : Clostridium difficle toxin in acute dirrhoea complicating inflammatory bowel disease. Gut 23 : 410-414, 1982 – reference: 6) Bolton RP, Sherriff RJ, Read AE : Clostridium difficile associated diarrhea : a role in inflammatory bowel disease? Lancet I 383-384, 1980 – reference: 13) 福田博英,井出孝,市村経敏ほか:Clostridium difficleを検出した13症例の臨床的検討.日消病会誌80 : 954-962, 1981 – reference: 18)稲松孝思:Clostridium difficleの毒素迅速同定.目医師会誌96 : 1896-1897, 1986 – reference: 1) Larson HE, Price AB, Honour P : Clostridium difficile and etiology of pseudomembranous colitis. Lancet I : 1063-1066, 1978 – reference: 2) Bartlett JG, Moon N, Chang TW, et al:Role of clostridium difficile in antibiotic-associated pseudomembranous colitis. Gastro-enterology 75 : 778-782, 1978 – reference: 9) Meyers S, Mayer L, Bottone E, et al : Occurrence of Clostridium difficle toxin during the course of inflammatory bowel disease.Gastroenterology 80 : 697-700, 1981 |
| SSID | ssib002484655 ssib002671002 ssj0064967 |
| Score | 1.2692362 |
| Snippet | The occurrence of Clostridium dificile toxin in feces was studied in 17 cases of ulcerative colitis (mild, 5 ; moderate, 11 ; severe, 1) (initial attack, 1 ;... |
| SourceID | unpaywall crossref jstage |
| SourceType | Open Access Repository Index Database Publisher |
| StartPage | 860 |
| Title | The Occurrence of Clostridium difficile Toxin in Ulcerative Colitis |
| URI | https://www.jstage.jst.go.jp/article/jcoloproctology1967/41/6/41_6_860/_article/-char/en https://www.jstage.jst.go.jp/article/jcoloproctology1967/41/6/41_6_860/_pdf |
| UnpaywallVersion | publishedVersion |
| Volume | 41 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Nippon Daicho Komonbyo Gakkai Zasshi, 1988, Vol.41(6), pp.860-863 |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1882-9619 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0064967 issn: 0047-1801 databaseCode: KQ8 dateStart: 19670101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8NAEB60FcSDD1SsqOTgNe9kNzmWYikKomChnsK-UlpjUmyD1l_vbJJW6UlBCEkOu0n2283sN-zsNwDXVIuMMRWYSGWVqdVRTE5jz8SZlnIXXaJQVAGy92QwDG5H4ahJBzRvwiqnyIvGSl-scWFNZ3YDoj3VQs7asFepXZc4eKgduDbBU0KSiDh2MpPpNrRJiMS8Be3h_UP3uV5jpqYbVcmQXc0pY_Qb6v3CPlL6zQdbgWtFlWjl91S1U3_VHuyW-Ywt31mW_ZiI-geQrZpQx5-8WOWCW-JzQ93xn9p4CPsNYTW6dcUj2FL5MfRwdBmFEJW4k8Db1OhlhU4BIiflq6GzrkwE2htjUXxMcgOPMhOqFhk3RBVyNz-BYf_mqTcwm3QMptAprUziSMZJin85YzRiHsf-J8JNkfGKiMZ6PVGJ2BNoMWNf8ohK9B5TJrmXUuFz4p9CKy9ydQZG4ElfcSdUKXMCwd1YOjKUIeEyFSRwog7YK-STWa26kaC3ovsq2QAoQVwQlQ4MakjX5RtAN8trQJMKyxWg65J6nxsaiw446y7-5dvP_17lAlqLt1JdIqVZ8CvYvnuMrpoB-wXckAIZ |
| linkProvider | Unpaywall |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NS8MwFA-6CeLBD1ScqPTgtd9t0h7HUIaH4cHBPJV8dWzWtrgWnX-9L003pScFobQ9JG3zS_rye-Tl9xC6JUpkjMrABCorTaWOYjISeybMtIS54BKFvAmQneDxNHiYhbM2HdCqDatcAi-aS3Wx5oW1LO0WRHuphJyVYW9Su65h8BA7cG0MpwQnEXbspBTpLurjEIh5D_Wnk8fhs15jJqYbNcmQXcUpY_Ab9H5hHyh998FW4FpRI1r5PVXt6a86QPt1XtL1O82yHxPR_RHKNk3Q8ScvVl0xi3921B3_qY3H6LAlrMZQVzxBOzI_RSMYXUbBeSPuxOE2NUZZoVKAiEX9aqisKwsO9saoio9FbsBRZ1xqkXGDNyF3qzM0vb97Go3NNh2DyVVKKxM7gjKcwl9OKYmox6D_MXdTYLw8IrFaT5Q89jhYzNgXLCICvMeUCualhPsM--eolxe5vEBG4AlfMieUKXUCztxYOCIUIWYi5ThwogGyN8gnpVbdSMBbUX2VdABKABdAZYDGGtJt-RbQbnkFaNJguQF0W1LtcwNjMUDOtot_-fbLv1e5Qr3qrZbXQGkqdtMO1S_VtQEk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Occurrence+of+Clostridium+difficile+Toxin+in+Ulcerative+Colitis&rft.jtitle=Nippon+Daicho+Komonbyo+Gakkai+Zasshi&rft.au=Iizuka%2C+M.&rft.au=Igarashi%2C+K.&rft.au=Chiba%2C+M.&rft.au=Kodama%2C+K.&rft.date=1988&rft.pub=The+Japan+Society+of+Coloproctology&rft.issn=0047-1801&rft.eissn=1882-9619&rft.volume=41&rft.issue=6&rft.spage=860&rft.epage=863&rft_id=info:doi/10.3862%2Fjcoloproctology.41.860&rft.externalDocID=article_jcoloproctology1967_41_6_41_6_860_article_char_en |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0047-1801&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0047-1801&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0047-1801&client=summon |