TUMOR MARKERS IN RATS WITH RENAL TUMOR INDUCED BY N-ETHYL-N-HYDROXYETHYLNITROSAMINE
Renal carcinomas were induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) followed by trisodium nitrilotriacetate monohydrate (NTA) in Wistar rats. In these rats, various parameters which are clinically used as tumor markers were examined. Renal tumors developed in 6 (37.5%) of 16 rats treated with...
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Published in | Journal of Toxicologic Pathology Vol. 3; no. 2; pp. 239 - 243 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Tokyo
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
1990
Japan Science and Technology Agency |
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Online Access | Get full text |
ISSN | 0914-9198 1881-915X 1347-7404 |
DOI | 10.1293/tox.3.239 |
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Abstract | Renal carcinomas were induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) followed by trisodium nitrilotriacetate monohydrate (NTA) in Wistar rats. In these rats, various parameters which are clinically used as tumor markers were examined. Renal tumors developed in 6 (37.5%) of 16 rats treated with EHEN alone and in 14 (82.4%) of 17 rats treated with EHEN and subsequently with NTA. When various parameters were compared between these two groups and the control group, RBC, Hb Al-P, LDH, BUN, Cr, and Ca in the former two groups differed significantly from those values of the untreated controls. In the EHEN-treated rats (Group 1 and 2), erythropoietin (EP) was higher in the tumor-bearing group than in the tumor-free group (p<0.025), although no other significant difference was observed. As compared to the untreated controls, tumor-bearing rats showed significant elevation in RBC (p<0.005). Cr (p<0.005), and EP (p<0.05) and significant reduction in Hb (p<0.005). Al-P (p<0.005), and LDH (p<0.05). Therefore, the significant difference in RBC, Hb, Al-P, LDH, and Cr seems to be attributable to the effect of EHEN and NTA. These results suggest that EP is specifically elevated in rats with renal tumor. |
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AbstractList | Renal carcinomas were induced by N-ethyl-N-hydroxyethylnitrosamine (EHEN) followed by trisodium nitrilotriacetate monohydrate (NTA) in Wistar rats. In these rats, various parameters which are clinically used as tumor markers were examined. Renal tumors developed in 6 (37.5%) of 16 rats treated with EHEN alone and in 14 (82.4%) of 17 rats treated with EHEN and subsequently with NTA. When various parameters were compared between these two groups and the control group, RBC, Hb Al-P, LDH, BUN, Cr, and Ca in the former two groups differed significantly from those values of the untreated controls. In the EHEN-treated rats (Group 1 and 2), erythropoietin (EP) was higher in the tumor-bearing group than in the tumor-free group (p<0.025), although no other significant difference was observed. As compared to the untreated controls, tumor-bearing rats showed significant elevation in RBC (p<0.005). Cr (p<0.005), and EP (p<0.05) and significant reduction in Hb (p<0.005). Al-P (p<0.005), and LDH (p<0.05). Therefore, the significant difference in RBC, Hb, Al-P, LDH, and Cr seems to be attributable to the effect of EHEN and NTA. These results suggest that EP is specifically elevated in rats with renal tumor. |
Author | Tabata, Shoichi Ozono, Seiichiro Hiasa, Yoshio Samma, Shoji Kitahori, Yoshiteru Okajima, Eigoro Hirao, Yoshihiko Matsuki, Hisashi Yamaguchi, Hisako Uemura, Hirotsugu Kitagawa, Hisayo |
Author_xml | – sequence: 1 fullname: Okajima, Eigoro organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Yamaguchi, Hisako organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Kitahori, Yoshiteru organization: 2nd Department of Pathology, Nara Medical University – sequence: 1 fullname: Hiasa, Yoshio organization: 2nd Department of Pathology, Nara Medical University – sequence: 1 fullname: Matsuki, Hisashi organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Hirao, Yoshihiko organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Uemura, Hirotsugu organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Samma, Shoji organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Ozono, Seiichiro organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Kitagawa, Hisayo organization: Department of Urology, Nara Medical University – sequence: 1 fullname: Tabata, Shoichi organization: Department of Urology, Nara Medical University |
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References | 12. Altaffer, LF and Chenault, OW: Paraneoplastic endocrinopathies associated with renal tumors. J Urol 122: 573-577, 1979. 4. Hiasa, Y, Enoki, N, Kitahori, Y, Konishi, N, and Shimoyama, T: DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats. J Natl Cancer Inst 73: 297-299, 1984. 8. Sufrin, G, Golio, A, and Murphy, GP: 4. Serologic markers, paraneoplastic syndromes, and ectopic hormone production in renal adenocarcinoma. In: Tumors of the Kidney, JB deKernion and M Pavone-Macaluso Ed, pp. 51-71, Williams & Wilkins, Baltimore, 1986. 2. Hiasa, Y, Ohshima, M, Kitahori, Y, Konishi, N, Fujita, T, and Yuasa, T: β-Cyclodextrin: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethylN-hydroxyethyl-nitrosamine. J Natl Cancer Inst 69: 963-967, 1982. 9. Suzuki, A, Masuda, H, Ohtawara, Y, Suzuki, K, Tajima, A, and Aso, Y: Serum tumor markers in renal cell carcinoma (in Japanese). Jpn J Urol 77: 87-91, 1986. 13. Sufrin, G, Mirand, EA, Moore, RH, Chu,TM, and Murphy, GP: Hormones in renal cancer. J Urol 117: 433-438, 1977. 16. Toyama, K, Fujiyama, N, Suzuki, H, Chen, TP, Tamaoki, N, and Ueyama. Y: Erythropoietin levels in the course of a patient with erythropoietin-producing renal cell carcinoma and transplantation of this tumor in nude mice. Blood 54: 245-253, 1979. 10. Okajima, E, Hirao, Y, Ozono, S, and Samma, S: Tumor markers in renal cell carcinoma (in Japanese). Jpn J Urol Surg 2: 423-426, 1989. 14. Chisholm, GD and Roy, RR: The systemic effects of malignant renal tumors. Br J Urol 43: 687-700, 1971. 5. Hiasa, Y and Ito, N: Experimental induction of renal tumors. CRC Clin Rev Toxicol 17: 279-343, 1987. 1. Scott. RE, Wille, JJ Jr, and Wier, ML: Mechanisms for the initiation and promotion of carcinogenesis: a review and a new concept. Mayo Clin Proc 59: 107-117, 1984. 3. Hiasa, Y, Ohshima, M, Kitahori, Y, Fujita, T, Yuasa T, and Miyashiro, A: Basic lead acetate: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine. J Natl Cancer Inst 70: 761-765, 1983. 6. Hiasa, Y, Kitahori, Y, Konishi, N. Enoki, N, Shimoyama, T, and Miyashiro, A: Trisodium nitrilotriacetate monohydrate: promoting effects on the development of renal tubular cell tumors in rats treated with N-ethyl-N- hydroxyethylnitrosamine. J Nail Cancer Inst 72: 483-489, 1984. 15. Katsuoka, Y, McGonigle, R, Rege, AB, Beckman, B, and Fisher, JW: Erythropoietin production in human renal carcinoma cells passaged in nude mice and in tissue culture. Gann 74: 534-541, 1983. 11. Nseyo, UO, Williams, PD, and Murphy, GP: Clinical significance of erythropoietin levels in renal carcinoma. Urology 28: 301-306, 1986. 7. Hiasa, Y, Kitahori, Y, Konishi, N, and Shimoyama, T: Dose related effect of trisodium nitrilotriacetate monohydrate on renal tumorigenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats. Carcinogenesis 6: 907-910, 1985. |
References_xml | – reference: 3. Hiasa, Y, Ohshima, M, Kitahori, Y, Fujita, T, Yuasa T, and Miyashiro, A: Basic lead acetate: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine. J Natl Cancer Inst 70: 761-765, 1983. – reference: 2. Hiasa, Y, Ohshima, M, Kitahori, Y, Konishi, N, Fujita, T, and Yuasa, T: β-Cyclodextrin: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethylN-hydroxyethyl-nitrosamine. J Natl Cancer Inst 69: 963-967, 1982. – reference: 4. Hiasa, Y, Enoki, N, Kitahori, Y, Konishi, N, and Shimoyama, T: DL-Serine: promoting activity on renal tumorigenesis by N-ethyl-N-hydroxyethylnitrosamine in rats. J Natl Cancer Inst 73: 297-299, 1984. – reference: 6. Hiasa, Y, Kitahori, Y, Konishi, N. Enoki, N, Shimoyama, T, and Miyashiro, A: Trisodium nitrilotriacetate monohydrate: promoting effects on the development of renal tubular cell tumors in rats treated with N-ethyl-N- hydroxyethylnitrosamine. J Nail Cancer Inst 72: 483-489, 1984. – reference: 11. Nseyo, UO, Williams, PD, and Murphy, GP: Clinical significance of erythropoietin levels in renal carcinoma. Urology 28: 301-306, 1986. – reference: 7. Hiasa, Y, Kitahori, Y, Konishi, N, and Shimoyama, T: Dose related effect of trisodium nitrilotriacetate monohydrate on renal tumorigenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats. Carcinogenesis 6: 907-910, 1985. – reference: 16. Toyama, K, Fujiyama, N, Suzuki, H, Chen, TP, Tamaoki, N, and Ueyama. Y: Erythropoietin levels in the course of a patient with erythropoietin-producing renal cell carcinoma and transplantation of this tumor in nude mice. Blood 54: 245-253, 1979. – reference: 14. Chisholm, GD and Roy, RR: The systemic effects of malignant renal tumors. Br J Urol 43: 687-700, 1971. – reference: 13. Sufrin, G, Mirand, EA, Moore, RH, Chu,TM, and Murphy, GP: Hormones in renal cancer. J Urol 117: 433-438, 1977. – reference: 8. Sufrin, G, Golio, A, and Murphy, GP: 4. Serologic markers, paraneoplastic syndromes, and ectopic hormone production in renal adenocarcinoma. In: Tumors of the Kidney, JB deKernion and M Pavone-Macaluso Ed, pp. 51-71, Williams & Wilkins, Baltimore, 1986. – reference: 15. Katsuoka, Y, McGonigle, R, Rege, AB, Beckman, B, and Fisher, JW: Erythropoietin production in human renal carcinoma cells passaged in nude mice and in tissue culture. Gann 74: 534-541, 1983. – reference: 1. Scott. RE, Wille, JJ Jr, and Wier, ML: Mechanisms for the initiation and promotion of carcinogenesis: a review and a new concept. Mayo Clin Proc 59: 107-117, 1984. – reference: 5. Hiasa, Y and Ito, N: Experimental induction of renal tumors. CRC Clin Rev Toxicol 17: 279-343, 1987. – reference: 10. Okajima, E, Hirao, Y, Ozono, S, and Samma, S: Tumor markers in renal cell carcinoma (in Japanese). Jpn J Urol Surg 2: 423-426, 1989. – reference: 9. Suzuki, A, Masuda, H, Ohtawara, Y, Suzuki, K, Tajima, A, and Aso, Y: Serum tumor markers in renal cell carcinoma (in Japanese). Jpn J Urol 77: 87-91, 1986. – reference: 12. Altaffer, LF and Chenault, OW: Paraneoplastic endocrinopathies associated with renal tumors. J Urol 122: 573-577, 1979. |
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