Advantages of fully automated AI-enhanced algorithm (5D CNS+™) for generating a fetal neurosonogram in clinical routine

• Published in: Journal of perinatal medicine
• Main Authors: Scharf, Jann Lennard, Gembicki, Michael, Rody, Achim, Welp, Amrei, Weichert, Jan
• Format: Journal Article
• Language: English
• Published: Germany 15.09.2025
• Subjects: 5D CNS; fetal neurosonography; automation; brain; artificial intelligence
• ISSN: 0300-5577; 1619-3997; 1619-3997
• DOI: 10.1515/jpm-2025-0188

The objective was to demonstrate superiority of a fully vs. semi-automated approach (5D CNS+™) and to verify operators could handle and benefit from a fully automated rendering volumetric datasets to generate a complete fetal neurosonogram. A total of 136 stored three-dimensional (3D) volumes of the brain of unselected, structurally normal fetuses were examined. Two operators applied both software versions for detailed assessment of the fetal central nervous system (CNS). The procession time was measured for each operator and for both program versions. The number of correctly calibrated planes were evaluated and necessity for manual adjustment of the planes was registered. The intraclass correlation coefficient was 0.507 (0.307-0.648) for semi-automated and 0.782 (0.693-0.846) for fully automated 5D CNS+™. The acquisition time of application for semi-automated 5D CNS+™ was 27.70 s ± 6.28 s for operator 1 and 33.20 s ± 9.67 s for operator 2, for fully automated 5D CNS+™ 10.89 s ± 0.85 s for operator 1 and 10.79 s ± 0.60 s for operator 2 (p<0.0001). The statistical analysis for manually corrected planes by both operators between both software algorithms showed a Bland-Altman-Bias of 1.44/9 planes for operator 1 and 1.45/9 planes for operator 2. The fully automated 5D CNS+™ algorithm applied on 3D volume datasets provides examiners regardless their expertise not only enormous time efficiency, but also diagnostic confidence in evaluating details of the fetal CNS. This tremendously simplifies application in clinical routine.