The chemical process of oxidative stress by copper(II) and iron(III) ions in several neurodegenerative disorders

The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which...

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Bibliographic Details
Published inMonatshefte für Chemie Vol. 142; no. 4; pp. 375 - 384
Main Author Nishida, Yuzo
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.04.2011
Subjects
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Review
Theoretical and Computational Chemistry
ALS
SOD
NTBI
Hydrogen peroxide
Binuclear iron(III) species
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ISSN0026-9247
1434-4475
DOI10.1007/s00706-010-0444-8

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Summary:The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with the involvement of transition metal ions. In this review, amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and prion disease are discussed, with the aim of identifying the common trends underlying these devastating neurological conditions by elucidating the chemical process of the oxidative stress due to copper(II) and iron(III) ions. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-010-0444-8