EEG functional connectivity after perinatal stroke

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 33; no. 17; pp. 9927 - 9935
• Main Authors: Kavčič, Alja, Demšar, Jure, Georgiev, Dejan, Meglič, Nuška Pečarič, Šalamon, Aneta Soltirovska
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 23.08.2023
• Subjects: perinatal stroke; functional connectivity; neonatal brain injury; functional brain networks; resting state EEG
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhad255

Abstract Impaired cognitive functioning after perinatal stroke has been associated with long-term functional brain network changes. We explored brain functional connectivity using a 64-channel resting-state electroencephalogram in 12 participants, aged 5–14 years with a history of unilateral perinatal arterial ischemic or haemorrhagic stroke. A control group of 16 neurologically healthy subjects was also included—each test subject was compared with multiple control subjects, matched by sex and age. Functional connectomes from the alpha frequency band were calculated for each subject and the differences in network graph metrics between the 2 groups were analyzed. Our results suggest that the functional brain networks of children with perinatal stroke show evidence of disruption even years after the insult and that the scale of changes appears to be influenced by the lesion volume. The networks remain more segregated and show a higher synchronization at both whole-brain and intrahemispheric level. Total interhemispheric strength was higher in children with perinatal stroke compared with healthy controls.