SOME HINTS ON OPEN READING FRAME STATISTICS — HOW ORF LENGTH DEPENDS ON SELECTION

Coding sequences of DNA generate Open Reading Frames (ORFs) inside them with much higher frequency than random DNA sequences do, especially in the antisense strand. This is a specific feature of the genetic code. Since coding sequences are selected for their length, the generated ORFs are indirect r...

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Bibliographic Details
Published inInternational journal of modern physics. C, Computational physics, physical computation Vol. 10; no. 4; pp. 635 - 643
Main Authors GIERLIK, AGNIESZKA, MACKIEWICZ, PAWEŁ, KOWALCZUK, MARIA, CEBRAT, STANISŁAW, DUDEK, MIROSŁAW R.
Format Journal Article
LanguageEnglish
Published World Scientific Publishing Company 01.06.1999
Subjects
Coding density
Genetic code properties
ORF generation
ORF length
Open reading frame
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ISSN0129-1831
1793-6586
DOI10.1142/S0129183199000474

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Summary:Coding sequences of DNA generate Open Reading Frames (ORFs) inside them with much higher frequency than random DNA sequences do, especially in the antisense strand. This is a specific feature of the genetic code. Since coding sequences are selected for their length, the generated ORFs are indirect results of this selection and their length is also influenced by selection. That is why ORFs found in any genome, even much longer ones than those spontaneously generated in random DNA sequences, should be considered as two different sets of ORFs: The first one coding for proteins, the second one generated by the coding ORFs. Even intergenic sequences possess greater capacity for generating ORFs than random DNA sequences of the same nucleotide composition, which seems to be a premise that intergenic sequences were generated from coding sequences by recombinational mechanisms.
ISSN:0129-1831
1793-6586
DOI:10.1142/S0129183199000474