Direct effect of alcohol on the motility and morphology of human spermatozoa
Excessive alcohol consumption has been associated with impaired reproductive function by causing the inhibition of penile tumescence and ejaculatory capability. Alcohol intoxication has also been implicated in impaired spermatogenesis and an increase in sperm structural anomalies. The aim of this st...
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| Published in | Andrologia Vol. 31; no. 1; pp. 43 - 47 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.1999
Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0303-4569 1439-0272 |
| DOI | 10.1111/j.1439-0272.1999.tb02841.x |
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| Abstract | Excessive alcohol consumption has been associated with impaired reproductive function by causing the inhibition of penile tumescence and ejaculatory capability. Alcohol intoxication has also been implicated in impaired spermatogenesis and an increase in sperm structural anomalies. The aim of this study was to determine the direct effects of alcohol on sperm motility and morphology in vitro.
Semen samples from 67 subjects were prepared using density centrifugation. Ethanol was added, at concentrations in serum equivalent to social, moderate and heavy drinking, to the medium in which the spermatozoa were cultured. Sperm motility was assessed using computer assisted semen analysis and morphology was assessed by Tygerberg strict criteria after 0, 15, 30, 60, 120, 180 and 240 min exposure. Each concentration of ethanol produced significant decreases in the percentage progressive motility, straight line velocity and curvilinear velocity. The amplitude of lateral head displacement was also depressed by 300 and 500 mg dL−1 of ethanol. A significant decrease in the number of spermatozoa with normal morphology and an increase in irreversible tail defects were observed after exposure to 300 mg dL−1 ethanol.
When alcohol is added directly to sperm, at concentrations equivalent to those in serum after moderate and heavy drinking, damaging effects are observed in both sperm motility and morphology. |
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| AbstractList | Excessive alcohol consumption has been associated with impaired reproductive function by causing the inhibition of penile tumescence and ejaculatory capability. Alcohol intoxication has also been implicated in impaired spermatogenesis and an increase in sperm structural anomalies. The aim of this study was to determine the direct effects of alcohol on sperm motility and morphology in vitro.
Semen samples from 67 subjects were prepared using density centrifugation. Ethanol was added, at concentrations in serum equivalent to social, moderate and heavy drinking, to the medium in which the spermatozoa were cultured. Sperm motility was assessed using computer assisted semen analysis and morphology was assessed by Tygerberg strict criteria after 0, 15, 30, 60, 120, 180 and 240 min exposure. Each concentration of ethanol produced significant decreases in the percentage progressive motility, straight line velocity and curvilinear velocity. The amplitude of lateral head displacement was also depressed by 300 and 500 mg dL−1 of ethanol. A significant decrease in the number of spermatozoa with normal morphology and an increase in irreversible tail defects were observed after exposure to 300 mg dL−1 ethanol.
When alcohol is added directly to sperm, at concentrations equivalent to those in serum after moderate and heavy drinking, damaging effects are observed in both sperm motility and morphology. Excessive alcohol consumption has been associated with impaired reproductive function by causing the inhibition of penile tumescence and ejaculatory capability. Alcohol intoxication has also been implicated in impaired spermatogenesis and an increase in sperm structural anomalies. The aim of this study was to determine the direct effects of alcohol on sperm motility and morphology in vitro. Semen samples from 67 subjects were prepared using density centrifugation. Ethanol was added, at concentrations in serum equivalent to social, moderate and heavy drinking, to the medium in which the spermatozoa were cultured. Sperm motility was assessed using computer assisted semen analysis and morphology was assessed by Tygerberg strict criteria after 0, 15, 30, 60, 120, 180 and 240 min exposure. Each concentration of ethanol produced significant decreases in the percentage progressive motility, straight line velocity and curvilinear velocity. The amplitude of lateral head displacement was also depressed by 300 and 500 mg dL-1 of ethanol. A significant decrease in the number of spermatozoa with normal morphology and an increase in irreversible tail defects were observed after exposure to 300 mg dL-1 ethanol. When alcohol is added directly to sperm, at concentrations equivalent to those in serum after moderate and heavy drinking, damaging effects are observed in both sperm motility and morphology.Excessive alcohol consumption has been associated with impaired reproductive function by causing the inhibition of penile tumescence and ejaculatory capability. Alcohol intoxication has also been implicated in impaired spermatogenesis and an increase in sperm structural anomalies. The aim of this study was to determine the direct effects of alcohol on sperm motility and morphology in vitro. Semen samples from 67 subjects were prepared using density centrifugation. Ethanol was added, at concentrations in serum equivalent to social, moderate and heavy drinking, to the medium in which the spermatozoa were cultured. Sperm motility was assessed using computer assisted semen analysis and morphology was assessed by Tygerberg strict criteria after 0, 15, 30, 60, 120, 180 and 240 min exposure. Each concentration of ethanol produced significant decreases in the percentage progressive motility, straight line velocity and curvilinear velocity. The amplitude of lateral head displacement was also depressed by 300 and 500 mg dL-1 of ethanol. A significant decrease in the number of spermatozoa with normal morphology and an increase in irreversible tail defects were observed after exposure to 300 mg dL-1 ethanol. When alcohol is added directly to sperm, at concentrations equivalent to those in serum after moderate and heavy drinking, damaging effects are observed in both sperm motility and morphology. Excessive alcohol consumption has been associated with impaired reproductive function by causing the inhibition of penile tumescence and ejaculatory capability. Alcohol intoxication has also been implicated in impaired spermatogenesis and an increase in sperm structural anomalies. The aim of this study was to determine the direct effects of alcohol on sperm motility and morphology in vitro. Semen samples from 67 subjects were prepared using density centrifugation. Ethanol was added, at concentrations in serum equivalent to social, moderate and heavy drinking, to the medium in which the spermatozoa were cultured. Sperm motility was assessed using computer assisted semen analysis and morphology was assessed by Tygerberg strict criteria after 0, 15, 30, 60, 120, 180 and 240 min exposure. Each concentration of ethanol produced significant decreases in the percentage progressive motility, straight line velocity and curvilinear velocity. The amplitude of lateral head displacement was also depressed by 300 and 500 mg dL-1 of ethanol. A significant decrease in the number of spermatozoa with normal morphology and an increase in irreversible tail defects were observed after exposure to 300 mg dL-1 ethanol. When alcohol is added directly to sperm, at concentrations equivalent to those in serum after moderate and heavy drinking, damaging effects are observed in both sperm motility and morphology. |
| Author | McClure, N. Lewis, S. E. M. Donnelly, G. P. Kennedy, M. S. |
| Author_xml | – sequence: 1 givenname: G. P. surname: Donnelly fullname: Donnelly, G. P. organization: Department of Obstetrics and Gynaecology, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road. Belfast, UK – sequence: 2 givenname: N. surname: McClure fullname: McClure, N. organization: Department of Obstetrics and Gynaecology, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road. Belfast, UK – sequence: 3 givenname: M. S. surname: Kennedy fullname: Kennedy, M. S. organization: Department of Obstetrics and Gynaecology, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road. Belfast, UK – sequence: 4 givenname: S. E. M. surname: Lewis fullname: Lewis, S. E. M. organization: Department of Obstetrics and Gynaecology, The Queen's University of Belfast, Institute of Clinical Science, Grosvenor Road. Belfast, UK |
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| Keywords | Human Spermatozoa Fertilizing ability Ethanol Semen Toxicity Alcoholism Mobility Male Germinal cell In vitro Sterility Reproduction Food intake Morphology |
| Language | English |
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| SubjectTerms | Alcoholism and acute alcohol poisoning Biological and medical sciences computer assisted semen analysis ethanol Ethanol - pharmacology Humans infertility Male Medical sciences morphology Sperm Sperm Motility - drug effects Spermatozoa - cytology Spermatozoa - drug effects Toxicology |
| Title | Direct effect of alcohol on the motility and morphology of human spermatozoa |
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