Fast and accurate generation method of PSF-based system matrix for PET reconstruction
This work investigates the positional single photon incidence response（P-SPIR） to provide an accurate point spread function（PSF）-contained system matrix and its incorporation within the image reconstruction framework.Based on the Geant4 Application for Emission Tomography（GATE） simulation,P-SPIR the...
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| Published in | Chinese physics C Vol. 41; no. 4; pp. 177 - 184 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
01.04.2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1674-1137 0254-3052 |
| DOI | 10.1088/1674-1137/41/4/048201 |
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| Abstract | This work investigates the positional single photon incidence response（P-SPIR） to provide an accurate point spread function（PSF）-contained system matrix and its incorporation within the image reconstruction framework.Based on the Geant4 Application for Emission Tomography（GATE） simulation,P-SPIR theory takes both incidence angle and incidence position of the gamma photon into account during crystal subdivision,instead of only taking the former into account,as in single photon incidence response（SPIR）.The response distribution obtained in this fashion was validated using Monte Carlo simulations.In addition,two-block penetration and normalization of the response probability are introduced to improve the accuracy of the PSF.With the incorporation of the PSF,the homogenization model is then analyzed to calculate the spread distribution of each line-of-response（LOR）.A primate PET scanner,Eplus-260,developed by the Institute of High Energy Physics,Chinese Academy of Sciences（IHEP）,was employed to evaluate the proposed method.The reconstructed images indicate that the P-SPIR method can effectively mitigate the depth-of-interaction（DOI） effect,especially at the peripheral area of field-of-view（FOV）.Furthermore,the method can be applied to PET scanners with any other structures and list-mode data format with high flexibility and efficiency. |
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| AbstractList | This work investigates the positional single photon incidence response（P-SPIR） to provide an accurate point spread function（PSF）-contained system matrix and its incorporation within the image reconstruction framework.Based on the Geant4 Application for Emission Tomography（GATE） simulation,P-SPIR theory takes both incidence angle and incidence position of the gamma photon into account during crystal subdivision,instead of only taking the former into account,as in single photon incidence response（SPIR）.The response distribution obtained in this fashion was validated using Monte Carlo simulations.In addition,two-block penetration and normalization of the response probability are introduced to improve the accuracy of the PSF.With the incorporation of the PSF,the homogenization model is then analyzed to calculate the spread distribution of each line-of-response（LOR）.A primate PET scanner,Eplus-260,developed by the Institute of High Energy Physics,Chinese Academy of Sciences（IHEP）,was employed to evaluate the proposed method.The reconstructed images indicate that the P-SPIR method can effectively mitigate the depth-of-interaction（DOI） effect,especially at the peripheral area of field-of-view（FOV）.Furthermore,the method can be applied to PET scanners with any other structures and list-mode data format with high flexibility and efficiency. |
| Author | 孙校丽 刘双全 贠明凯 李道武 高娟 李默涵 柴培 唐浩辉 章志明 魏龙 |
| AuthorAffiliation | Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 10049, China University of Chinese Academy of Sciences, Beijing 100049, China |
| Author_xml | – sequence: 1 fullname: 孙校丽 刘双全 贠明凯 李道武 高娟 李默涵 柴培 唐浩辉 章志明 魏龙 |
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| CitedBy_id | crossref_primary_10_1016_j_petrol_2019_106283 crossref_primary_10_1002_mp_17469 |
| Cites_doi | 10.1088/0031-9155/60/1/137 10.1088/0031-9155/58/19/6749 10.1007/s00259-009-1156-3 10.1016/j.nima.2004.03.117 10.1109/42.158942 10.1109/TNS.2008.2005903 10.1109/TNS.2005.862979 10.1109/TNS.2015.2421908 10.1109/TNS.2010.2044892 10.1109/TNS.2004.834827 10.1109/TNS.2003.817944 10.1088/0031-9155/55/5/013 10.1063/1.4894085 10.1259/bjr.20150938 10.1109/NSSMIC.2004.1466625 10.1088/0031-9155/57/21/6827 10.1088/0031-9155/59/3/561 10.1088/0031-9155/56/20/015 10.1088/0031-9155/56/1/016 10.1007/s12194-015-0343-0 10.1088/0031-9155/49/19/008 10.1088/0031-9155/43/4/027 |
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| DocumentTitleAlternate | Fast and accurate generation method of PSF-based system matrix for PET reconstruction |
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| Notes | 11-5641/O4 PSF, P-SPIR, system matrix, GATE, PET reconstruction Xiao-Li Sun1,2,3, Shuang-Quan Liu1,2, Ming-Kai Yun1,2, Dao-Wu Li1,2,Juan Gao1,2, Mo-Han Li1,2,3 ,Pei Chai1,2（ 1 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China ;2 Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 10049, China ;3 University of Chinese Academy of Sciences, Beijing 100049, China） This work investigates the positional single photon incidence response（P-SPIR） to provide an accurate point spread function（PSF）-contained system matrix and its incorporation within the image reconstruction framework.Based on the Geant4 Application for Emission Tomography（GATE） simulation,P-SPIR theory takes both incidence angle and incidence position of the gamma photon into account during crystal subdivision,instead of only taking the former into account,as in single photon incidence response（SPIR）.The response distribution obtained in this fashion was validated using Monte Carlo simulations.In addition,two-block penetration and normalization of the response probability are introduced to improve the accuracy of the PSF.With the incorporation of the PSF,the homogenization model is then analyzed to calculate the spread distribution of each line-of-response（LOR）.A primate PET scanner,Eplus-260,developed by the Institute of High Energy Physics,Chinese Academy of Sciences（IHEP）,was employed to evaluate the proposed method.The reconstructed images indicate that the P-SPIR method can effectively mitigate the depth-of-interaction（DOI） effect,especially at the peripheral area of field-of-view（FOV）.Furthermore,the method can be applied to PET scanners with any other structures and list-mode data format with high flexibility and efficiency. |
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| SubjectTerms | Geant4 PET PSF 模拟验证 生成方法 矩阵 系统 高能物理研究所 |
| Title | Fast and accurate generation method of PSF-based system matrix for PET reconstruction |
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