Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects
Functional drinks enhanced with putatively bioactive polyphenols are receiving extensive interest due to their potential health benefits. A randomized, controlled, double-blind cross-over study design was used to assess postprandial glycemic responses to a basic blackcurrant juice and a blackcurrant...
Saved in:
| Published in | Journal of functional foods Vol. 4; no. 4; pp. 746 - 756 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.10.2012
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1756-4646 |
| DOI | 10.1016/j.jff.2012.05.001 |
Cover
| Abstract | Functional drinks enhanced with putatively bioactive polyphenols are receiving extensive interest due to their potential health benefits. A randomized, controlled, double-blind cross-over study design was used to assess postprandial glycemic responses to a basic blackcurrant juice and a blackcurrant juice fortified with crowberry powder (respective polyphenol contents 159 and 293mg/100mL), both sweetened with sucrose. Concurrently, we studied the presence of polyphenol-derived metabolites in plasma and urine to confirm their bioavailability. Urinary metabolites characteristic of cyanidin anthocyanins (such as dihydroxybenzoic acid sulphate and dihydroxyphenylacetic acid sulphate) increased after intake and were present in higher levels after intake of the fortified juice. Compared to the basic juice, the fortified juice elicited slightly attenuated and sustained plasma glucose and insulin responses. In conclusion, fortification of blackcurrant juice with crowberry doubled the polyphenol content and improved postprandial glycemic control in healthy subjects. This gives encouragement for further functional food development. |
|---|---|
| AbstractList | Functional drinks enhanced with putatively bioactive polyphenols are receiving extensive interest due to their potential health benefits. A randomized, controlled, double-blind cross-over study design was used to assess postprandial glycemic responses to a basic blackcurrant juice and a blackcurrant juice fortified with crowberry powder (respective polyphenol contents 159 and 293mg/100mL), both sweetened with sucrose. Concurrently, we studied the presence of polyphenol-derived metabolites in plasma and urine to confirm their bioavailability. Urinary metabolites characteristic of cyanidin anthocyanins (such as dihydroxybenzoic acid sulphate and dihydroxyphenylacetic acid sulphate) increased after intake and were present in higher levels after intake of the fortified juice. Compared to the basic juice, the fortified juice elicited slightly attenuated and sustained plasma glucose and insulin responses. In conclusion, fortification of blackcurrant juice with crowberry doubled the polyphenol content and improved postprandial glycemic control in healthy subjects. This gives encouragement for further functional food development. |
| Author | Pihlava, Juha-Matti Mattila, Pirjo Karjalainen, Reijo Törrönen, Riitta Hellström, Jarkko McDougall, Gordon J. Koskela, Ali Dobson, Gary Stewart, Derek |
| Author_xml | – sequence: 1 givenname: Riitta surname: Törrönen fullname: Törrönen, Riitta – sequence: 2 givenname: Gordon J. surname: McDougall fullname: McDougall, Gordon J. – sequence: 3 givenname: Gary surname: Dobson fullname: Dobson, Gary – sequence: 4 givenname: Derek surname: Stewart fullname: Stewart, Derek – sequence: 5 givenname: Jarkko surname: Hellström fullname: Hellström, Jarkko – sequence: 6 givenname: Pirjo surname: Mattila fullname: Mattila, Pirjo – sequence: 7 givenname: Juha-Matti surname: Pihlava fullname: Pihlava, Juha-Matti – sequence: 8 givenname: Ali surname: Koskela fullname: Koskela, Ali – sequence: 9 givenname: Reijo surname: Karjalainen fullname: Karjalainen, Reijo |
| BookMark | eNp9kb1u3DAQhFnYQPyTB0jHMoVPISmJOqULjPgHMOAmqYkltcpRoUiFpGDolfyU4eVSuXC1C-w3s8DMJTnzwSMhnzirOOPyy1RN41gJxkXF2ooxfkYueNfKXSMb-YFcpjQxJiWv2QV5vQsx29EayDZ4GkaqHZjfZo0RfKbTag3SF5sP1MTwojHG7St9nBcwmRZ-CW5bDuiDoybMS0j2aHND12g9xI2ebtbQGTPosmVMNxT8UJQpL-XHYMHRX24zOBcsYlqCT0itpwcElw8bTaue0OR0Tc5HcAk__p9X5Ofd9x-3D7un5_vH229POyO6fd71DTbQaTm0LZMNaD0YHMy-EazvGUCt9d4MoGUzAIyyBglDK3rRIzMaeT_WV-TzyXeJ4c-KKavZJoPOgcewJsU7zgQXoq0L2p3QEk5KEUdlbP6XZI5gneJMHRtRkyqNqGMjirWqNFKU_I1yiXYukb2j-QvSXJsA |
| CitedBy_id | crossref_primary_10_3390_metabo11060338 crossref_primary_10_1039_D1FO03169D crossref_primary_10_3390_foods11233859 crossref_primary_10_1080_10408398_2017_1404442 crossref_primary_10_3109_09637486_2013_869798 crossref_primary_10_3389_fnut_2018_00087 crossref_primary_10_1007_s11947_013_1091_y crossref_primary_10_1002_mnfr_201500236 crossref_primary_10_1016_j_lwt_2024_116655 crossref_primary_10_1016_j_jff_2013_02_002 crossref_primary_10_1016_j_jnutbio_2016_09_002 crossref_primary_10_1016_j_tifs_2019_04_011 crossref_primary_10_3390_foods12193707 crossref_primary_10_1016_j_nutres_2013_08_002 crossref_primary_10_1016_j_jff_2013_12_025 crossref_primary_10_1080_10408398_2018_1544883 crossref_primary_10_1021_acs_jafc_3c01142 crossref_primary_10_3390_nu12102930 crossref_primary_10_1080_10408398_2015_1087963 crossref_primary_10_3390_nu13020312 crossref_primary_10_1155_2016_9070537 crossref_primary_10_20289_zfdergi_1433287 crossref_primary_10_3390_antiox10010032 crossref_primary_10_1007_s11306_020_1647_6 crossref_primary_10_1016_j_jff_2015_10_037 crossref_primary_10_3109_10717544_2016_1143058 crossref_primary_10_1111_1541_4337_12109 crossref_primary_10_1016_j_phytol_2017_05_016 crossref_primary_10_3390_pr2030596 crossref_primary_10_1016_j_foodres_2024_114567 crossref_primary_10_1080_01496395_2020_1802485 crossref_primary_10_1007_s13596_021_00612_4 crossref_primary_10_3390_foods9020219 crossref_primary_10_1186_s12263_020_00675_z crossref_primary_10_7759_cureus_44181 crossref_primary_10_3390_foods9010041 crossref_primary_10_3390_nu10040438 crossref_primary_10_3390_molecules25020371 crossref_primary_10_1017_jns_2014_7 crossref_primary_10_1007_s12229_021_09248_0 crossref_primary_10_1016_j_lwt_2021_111173 crossref_primary_10_3390_molecules21121685 |
| Cites_doi | 10.1016/j.ifset.2004.08.003 10.1016/j.foodchem.2009.01.056 10.1093/ajcn/87.2.323 10.1021/jf0615247 10.1093/jn/130.8.2073S 10.1097/MED.0b013e3283471c74 10.1021/jf902693r 10.3945/jn.108.098020 10.3945/jn.109.118216 10.1021/jf901434d 10.1016/j.foodchem.2007.11.052 10.1021/jf902263n 10.1021/jf1037695 10.1002/jsfa.3721 10.1093/jn/137.8.1951 10.1021/jf800406v 10.1093/jn/138.4.747 10.1021/jf0486850 10.1016/j.jnutbio.2007.12.007 10.1002/mnfr.200700092 10.1021/jf00024a011 10.3390/ijms11041365 10.1021/jf904096v 10.1017/S0007114509992868 10.1111/j.1750-3841.2008.00996.x 10.1093/jn/137.9.2043 10.1021/jf8005917 10.1080/1028415031000111282 10.1002/mnfr.201000019 10.1021/jf8035116 10.1080/10715760100301441 10.1093/ajcn/81.1.230S 10.1021/jf071993o 10.1080/10408390500511862 10.1021/jf703676m 10.1111/j.1467-789X.2007.00337.x 10.1016/j.freeradbiomed.2008.04.008 10.1016/j.foodchem.2011.01.129 10.1021/jf8007037 10.1167/iovs.06-0452 10.1021/jf801336s 10.1021/jf020028p 10.1021/jf9027365 10.1021/jf0489926 10.1038/sj.ejcn.1600972 10.1158/1940-6207.CAPR-08-0201 10.1016/j.bcp.2007.08.008 10.1017/S0007114511004557 10.1021/jf9029332 10.1016/j.foodchem.2010.08.005 10.1001/jama.287.18.2414 10.1021/jf900602b 10.1016/j.canlet.2008.05.020 10.1021/jf062897a 10.1016/j.foodchem.2008.11.086 |
| ContentType | Journal Article |
| DBID | AAYXX CITATION 7S9 L.6 |
| DOI | 10.1016/j.jff.2012.05.001 |
| DatabaseName | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EndPage | 756 |
| ExternalDocumentID | 10_1016_j_jff_2012_05_001 |
| GroupedDBID | --K --M .~1 0R~ 1B1 1~. 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ AAEDT AAEDW AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AATLK AATTM AAXKI AAXUO AAYWO AAYXX ABFNM ABGRD ABGSF ABJNI ABMAC ABWVN ABXDB ACDAQ ACGFS ACNNM ACRLP ACRPL ACVFH ADBBV ADCNI ADECG ADEZE ADMUD ADNMO ADQTV ADUVX ADVLN AEBSH AEHWI AEIPS AEKER AENEX AEQOU AEUPX AEXQZ AFJKZ AFPUW AFTJW AFXIZ AFZHZ AGCQF AGHFR AGRNS AGUBO AGYEJ AIEXJ AIGII AIIUN AIKHN AITUG AJSZI AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP AXJTR BKOJK BLXMC BNPGV CITATION EBS EFJIC EJD EP2 EP3 F5P FDB FEDTE FIRID FLBIZ FNPLU FYGXN GBLVA GROUPED_DOAJ HVGLF HZ~ J1W KOM M41 MO0 N9A O-L O9- OAUVE OK1 OZT P-8 P-9 P2P PC. Q38 RIG ROL SDF SES SPC SSA SSH SSK SSU SSZ T5K ~G- 7S9 ACLOT EFKBS EFLBG L.6 ~HD |
| ID | FETCH-LOGICAL-c278t-94e4a7b6d55064abbdcedc8420990aa3bb8cdab64daaf63a6ad52929e0cbe19f3 |
| ISSN | 1756-4646 |
| IngestDate | Sun Sep 28 00:34:53 EDT 2025 Tue Jul 01 03:10:28 EDT 2025 Thu Apr 24 22:58:26 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c278t-94e4a7b6d55064abbdcedc8420990aa3bb8cdab64daaf63a6ad52929e0cbe19f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PQID | 1710212253 |
| PQPubID | 24069 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_1710212253 crossref_citationtrail_10_1016_j_jff_2012_05_001 crossref_primary_10_1016_j_jff_2012_05_001 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-10-00 20121001 |
| PublicationDateYYYYMMDD | 2012-10-01 |
| PublicationDate_xml | – month: 10 year: 2012 text: 2012-10-00 |
| PublicationDecade | 2010 |
| PublicationTitle | Journal of functional foods |
| PublicationYear | 2012 |
| References | Nakamura (10.1016/j.jff.2012.05.001_b0280) 2010; 58 Gonzáles-Molina (10.1016/j.jff.2012.05.001_b0035) 2009; 115 Takikawa (10.1016/j.jff.2012.05.001_b0225) 2010; 140 McDougall (10.1016/j.jff.2012.05.001_b0155) 2005; 53 Milbury (10.1016/j.jff.2012.05.001_b0170) 2007; 48 Erlund (10.1016/j.jff.2012.05.001_b0030) 2008; 87 Jaeger (10.1016/j.jff.2012.05.001_b0065) 2009; 89 Landbo (10.1016/j.jff.2012.05.001_b0115) 2004; 5 Hertog (10.1016/j.jff.2012.05.001_b0055) 1992; 40 Pedersen (10.1016/j.jff.2012.05.001_b0190) 2000; 54 McCormick (10.1016/j.jff.2012.05.001_b0150) 2007; 8 Dikeman (10.1016/j.jff.2012.05.001_b0025) 2006; 46 Laaksonen (10.1016/j.jff.2012.05.001_b0110) 2011; 124 Borges (10.1016/j.jff.2012.05.001_b0015) 2010; 58 Toufektsian (10.1016/j.jff.2012.05.001_b0245) 2008; 138 Walton (10.1016/j.jff.2012.05.001_b0255) 2010; 74 Karlsen (10.1016/j.jff.2012.05.001_b0080) 2007; 137 McGhie (10.1016/j.jff.2012.05.001_b0160) 2007; 51 Koponen (10.1016/j.jff.2012.05.001_b0090) 2007; 55 Törrönen (10.1016/j.jff.2012.05.001_b0285) 2012; 107 Scalbert (10.1016/j.jff.2012.05.001_b0220) 2000; 130 Ludwig (10.1016/j.jff.2012.05.001_b0120) 2002; 287 Ogawa (10.1016/j.jff.2012.05.001_b0185) 2008; 56 Popkin (10.1016/j.jff.2012.05.001_b0195) 2011; 18 Nurmi (10.1016/j.jff.2012.05.001_b0180) 2009; 57 Manach (10.1016/j.jff.2012.05.001_b0125) 2005; 81 Hanhineva (10.1016/j.jff.2012.05.001_b0040) 2010; 11 Mattila (10.1016/j.jff.2012.05.001_b0135) 2002; 50 Wang (10.1016/j.jff.2012.05.001_b0260) 2008; 269 Jing (10.1016/j.jff.2012.05.001_b0070) 2008; 56 Hollands (10.1016/j.jff.2012.05.001_b0060) 2008; 108 Kellogg (10.1016/j.jff.2012.05.001_b0085) 2010; 58 Joseph (10.1016/j.jff.2012.05.001_b0075) 2003; 6 Rayalam (10.1016/j.jff.2012.05.001_b0205) 2008; 19 Vitaglione (10.1016/j.jff.2012.05.001_b0250) 2007; 137 Bantle (10.1016/j.jff.2012.05.001_b0010) 2009; 139 Manzano (10.1016/j.jff.2012.05.001_b0130) 2010; 54 Hellström (10.1016/j.jff.2012.05.001_b0050) 2009; 57 Mattila (10.1016/j.jff.2012.05.001_b0140) 2006; 54 Koponen (10.1016/j.jff.2012.05.001_b0095) 2008; 56 Prior (10.1016/j.jff.2012.05.001_b0200) 2008; 56 Mullen (10.1016/j.jff.2012.05.001_b0175) 2010; 58 Williams (10.1016/j.jff.2012.05.001_b0265) 2008; 45 Woodward (10.1016/j.jff.2012.05.001_b0270) 2009; 57 Krikorian (10.1016/j.jff.2012.05.001_b0105) 2010; 58 Russell (10.1016/j.jff.2012.05.001_b0210) 2009; 115 Thomasset (10.1016/j.jff.2012.05.001_b0230) 2009; 2 Mertens-Talcott (10.1016/j.jff.2012.05.001_b0165) 2008; 56 Hellström (10.1016/j.jff.2012.05.001_b0045) 2008; 56 Törrönen (10.1016/j.jff.2012.05.001_b0235) 2010; 103 Sasaki (10.1016/j.jff.2012.05.001_b0215) 2007; 74 10.1016/j.jff.2012.05.001_b0005 Koskela (10.1016/j.jff.2012.05.001_b0100) 2010; 58 Day (10.1016/j.jff.2012.05.001_b0020) 2001; 35 Mattila (10.1016/j.jff.2012.05.001_b0145) 2011; 127 Wu (10.1016/j.jff.2012.05.001_b0275) 2004; 52 |
| References_xml | – volume: 5 start-page: 503 year: 2004 ident: 10.1016/j.jff.2012.05.001_b0115 article-title: Effects of different enzymatic maceration treatments on enhancement of anthocyanins and other phenolics in black currant juice publication-title: Innovative Food Science and Emerging Technologies doi: 10.1016/j.ifset.2004.08.003 – volume: 115 start-page: 1364 year: 2009 ident: 10.1016/j.jff.2012.05.001_b0035 article-title: A new drink rich in healthy bioactives combining lemon and pomegranate juices publication-title: Food Chemistry doi: 10.1016/j.foodchem.2009.01.056 – volume: 87 start-page: 323 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0030 article-title: Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol publication-title: American Journal of Clinical Nutrition doi: 10.1093/ajcn/87.2.323 – volume: 54 start-page: 7193 year: 2006 ident: 10.1016/j.jff.2012.05.001_b0140 article-title: Phenolic acids in berries, fruits, and beverages publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf0615247 – volume: 130 start-page: 2073S year: 2000 ident: 10.1016/j.jff.2012.05.001_b0220 article-title: Dietary intake and bioavailability of polyphenols publication-title: Journal of Nutrition doi: 10.1093/jn/130.8.2073S – volume: 18 start-page: 328 year: 2011 ident: 10.1016/j.jff.2012.05.001_b0195 article-title: Is the obesity epidemic a national security issue around the globe? publication-title: Current Opinion in Endocrinology, Diabetes, and Obesity doi: 10.1097/MED.0b013e3283471c74 – volume: 58 start-page: 3884 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0085 article-title: Alaskan wild berry resources and human health under the cloud of climate change publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf902693r – volume: 139 start-page: 1263S year: 2009 ident: 10.1016/j.jff.2012.05.001_b0010 article-title: Dietary fructose and metabolic syndrome and diabetes publication-title: Journal of Nutrition doi: 10.3945/jn.108.098020 – volume: 140 start-page: 527 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0225 article-title: Dietary anthocyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice publication-title: Journal of Nutrition doi: 10.3945/jn.109.118216 – volume: 57 start-page: 7899 year: 2009 ident: 10.1016/j.jff.2012.05.001_b0050 article-title: Proanthocyanidins in common food products of plant origin publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf901434d – volume: 108 start-page: 869 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0060 article-title: Processing blackcurrant dramatically reduces the content and does not enhance the urinary yield of anthocyanins in human subjects publication-title: Food Chemistry doi: 10.1016/j.foodchem.2007.11.052 – volume: 58 start-page: 3901 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0015 article-title: Identification of flavonoid and phenolic antioxidants in black currants, blueberries, raspberries, red currants, and cranberries publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf902263n – volume: 58 start-page: 12286 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0100 article-title: Variation in the anthocyanin concentration of wild populations of crowberries (Empetrum nigrum L subsp. hermaphroditum) publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf1037695 – volume: 89 start-page: 2356 year: 2009 ident: 10.1016/j.jff.2012.05.001_b0065 article-title: Polyphenol-rich beverages: insights from sensory and consumer science publication-title: Journal of the Science of Food and Agriculture doi: 10.1002/jsfa.3721 – volume: 137 start-page: 1951 year: 2007 ident: 10.1016/j.jff.2012.05.001_b0080 article-title: Anthocyanins inhibit nuclear factor-kB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults publication-title: Journal of Nutrition doi: 10.1093/jn/137.8.1951 – volume: 56 start-page: 4457 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0185 article-title: Anthocyanin composition and antioxidant activity of the crowberry (Empetrum nigrum) and other berries publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf800406v – volume: 138 start-page: 747 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0245 article-title: Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury publication-title: Journal of Nutrition doi: 10.1093/jn/138.4.747 – volume: 52 start-page: 7846 year: 2004 ident: 10.1016/j.jff.2012.05.001_b0275 article-title: Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf0486850 – volume: 19 start-page: 717 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0205 article-title: Phytochemicals and regulation of the adipocyte life cycle publication-title: Journal of Nutritional Biochemistry doi: 10.1016/j.jnutbio.2007.12.007 – volume: 51 start-page: 702 year: 2007 ident: 10.1016/j.jff.2012.05.001_b0160 article-title: The bioavailability and absorption of anthocyanins: Towards a better understanding publication-title: Molecular Nutrition and Food Research doi: 10.1002/mnfr.200700092 – volume: 40 start-page: 2379 year: 1992 ident: 10.1016/j.jff.2012.05.001_b0055 article-title: Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands publication-title: Journal of Agricultural Food Chemistry doi: 10.1021/jf00024a011 – volume: 11 start-page: 1365 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0040 article-title: Impact of dietary polyphenols on carbohydrate metabolism publication-title: International Journal of Molecular Sciences doi: 10.3390/ijms11041365 – volume: 58 start-page: 2586 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0175 article-title: Identification of metabolites in human plasma and urine after consumption of a polyphenol-rich juice drink publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf904096v – volume: 103 start-page: 1094 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0235 article-title: Berries modify the postprandial plasma glucose response to sucrose in healthy subjects publication-title: British Journal of Nutrition doi: 10.1017/S0007114509992868 – volume: 74 start-page: H22 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0255 article-title: Viscous food matrix influences absorption and excretion but not metabolism of black currant anthocyanins in rats publication-title: Journal of Food Science doi: 10.1111/j.1750-3841.2008.00996.x – volume: 137 start-page: 2043 year: 2007 ident: 10.1016/j.jff.2012.05.001_b0250 article-title: Protocatechuic acid is the major human metabolite of cyanidin glucosides publication-title: Journal of Nutrition doi: 10.1093/jn/137.9.2043 – volume: 56 start-page: 9391 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0070 article-title: Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf8005917 – volume: 6 start-page: 153 year: 2003 ident: 10.1016/j.jff.2012.05.001_b0075 article-title: Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model publication-title: Nutritional Neuroscience doi: 10.1080/1028415031000111282 – volume: 54 start-page: 1773 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0130 article-title: Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells publication-title: Molecular Nutrition and Food Research doi: 10.1002/mnfr.201000019 – volume: 57 start-page: 2274 year: 2009 ident: 10.1016/j.jff.2012.05.001_b0180 article-title: Metabolism of berry anthocyanins to phenolic acids in humans publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf8035116 – volume: 35 start-page: 941 year: 2001 ident: 10.1016/j.jff.2012.05.001_b0020 article-title: Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin publication-title: Free Radical Research doi: 10.1080/10715760100301441 – volume: 81 start-page: 230S issue: Suppl. year: 2005 ident: 10.1016/j.jff.2012.05.001_b0125 article-title: Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies publication-title: American Journal of Clinical Nutrition doi: 10.1093/ajcn/81.1.230S – volume: 56 start-page: 647 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0200 article-title: Whole berries versus berry anthocyanins: Interactions with dietary fat levels in the C57BL/6J mouse model of obesity publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf071993o – volume: 46 start-page: 649 year: 2006 ident: 10.1016/j.jff.2012.05.001_b0025 article-title: Viscosity as related to dietary fiber: A review publication-title: Critical Reviews in Food Science and Nutrition doi: 10.1080/10408390500511862 – volume: 56 start-page: 3136 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0095 article-title: Characterization and fate of black currant and bilberry flavonols in enzyme-aided processing publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf703676m – volume: 8 start-page: 161 issue: Suppl. 1 year: 2007 ident: 10.1016/j.jff.2012.05.001_b0150 article-title: Economic costs of obesity and the case for government intervention publication-title: Obesity Reviews doi: 10.1111/j.1467-789X.2007.00337.x – volume: 45 start-page: 295 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0265 article-title: Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels publication-title: Free Radical Biology and Medicine doi: 10.1016/j.freeradbiomed.2008.04.008 – volume: 127 start-page: 1216 year: 2011 ident: 10.1016/j.jff.2012.05.001_b0145 article-title: Polyphenol and vitamin C contents in European commercial blackcurrant juice products publication-title: Food Chemistry doi: 10.1016/j.foodchem.2011.01.129 – volume: 56 start-page: 7796 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0165 article-title: Pharmacokinetics of anthocyanins and antioxidant effects after the consumption of anthocyanin-rich acai juice and pulp (Euterpe oleracea Mart.) in human healthy volunteers publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf8007037 – volume: 48 start-page: 2343 year: 2007 ident: 10.1016/j.jff.2012.05.001_b0170 article-title: Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in APRE-19 cells publication-title: Investigative Ophthalmology and Visual Science doi: 10.1167/iovs.06-0452 – volume: 56 start-page: 7617 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0045 article-title: HPLC determination of extractable and unextractable proanthocyanidins in plant materials publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf801336s – volume: 50 start-page: 3660 year: 2002 ident: 10.1016/j.jff.2012.05.001_b0135 article-title: Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf020028p – volume: 58 start-page: 1174 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0280 article-title: Development and validation of a liquid chromatography tandem mass spectrometry method for simultaneous determination of four anthocyanins in human plasma after black currant anthocyanins ingestion publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf9027365 – volume: 53 start-page: 2760 year: 2005 ident: 10.1016/j.jff.2012.05.001_b0155 article-title: Different polyphenolic components of soft fruits inhibit α-amylase and α-glucosidase publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf0489926 – volume: 54 start-page: 405 year: 2000 ident: 10.1016/j.jff.2012.05.001_b0190 article-title: Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers publication-title: European Journal of Clinical Nutrition doi: 10.1038/sj.ejcn.1600972 – ident: 10.1016/j.jff.2012.05.001_b0005 – volume: 2 start-page: 625 year: 2009 ident: 10.1016/j.jff.2012.05.001_b0230 article-title: Pilot study of oral anthocyanins for colorectal cancer chemoprevention publication-title: Cancer Prevention Research (Philadelphia, PA) doi: 10.1158/1940-6207.CAPR-08-0201 – volume: 74 start-page: 1619 year: 2007 ident: 10.1016/j.jff.2012.05.001_b0215 article-title: Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice publication-title: Biochemical Pharmacology doi: 10.1016/j.bcp.2007.08.008 – volume: 107 start-page: 1445 year: 2012 ident: 10.1016/j.jff.2012.05.001_b0285 article-title: Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects publication-title: British Journal of Nutrition doi: 10.1017/S0007114511004557 – volume: 58 start-page: 3996 year: 2010 ident: 10.1016/j.jff.2012.05.001_b0105 article-title: Blueberry supplementation improves memory in older adults publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf9029332 – volume: 124 start-page: 1514 year: 2011 ident: 10.1016/j.jff.2012.05.001_b0110 article-title: Orosensory contributing compounds in crowberry (Empetrum nigrum) press by-products publication-title: Food Chemistry doi: 10.1016/j.foodchem.2010.08.005 – volume: 287 start-page: 2414 year: 2002 ident: 10.1016/j.jff.2012.05.001_b0120 article-title: The glycemic index. Physiological mechanisms relating to obesity, diabetes, and cardiovascular disease publication-title: Journal of the American Medical Association doi: 10.1001/jama.287.18.2414 – volume: 57 start-page: 5271 year: 2009 ident: 10.1016/j.jff.2012.05.001_b0270 article-title: Anthocyanin stability and recovery: Implications for the analysis of clinical and experimental samples publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf900602b – volume: 269 start-page: 281 year: 2008 ident: 10.1016/j.jff.2012.05.001_b0260 article-title: Anthocyanins and their role in cancer prevention publication-title: Cancer Letters doi: 10.1016/j.canlet.2008.05.020 – volume: 55 start-page: 1612 year: 2007 ident: 10.1016/j.jff.2012.05.001_b0090 article-title: Contents of anthocyanins and ellagitannins in selected foods consumed in Finland publication-title: Journal of Agricultural and Food Chemistry doi: 10.1021/jf062897a – volume: 115 start-page: 100 year: 2009 ident: 10.1016/j.jff.2012.05.001_b0210 article-title: Phenolic acid content of fruits commonly consumed and locally produced in Scotland publication-title: Food Chemistry doi: 10.1016/j.foodchem.2008.11.086 |
| SSID | ssj0066130 |
| Score | 2.2026508 |
| Snippet | Functional drinks enhanced with putatively bioactive polyphenols are receiving extensive interest due to their potential health benefits. A randomized,... |
| SourceID | proquest crossref |
| SourceType | Aggregation Database Enrichment Source Index Database |
| StartPage | 746 |
| SubjectTerms | anthocyanins beverages bioactive properties bioavailability black currants blood glucose cross-over studies cyanidin experimental design functional foods glycemic control insulin juices metabolites polyphenols sucrose urine |
| Title | Fortification of blackcurrant juice with crowberry: Impact on polyphenol composition, urinary phenolic metabolites, and postprandial glycemic response in healthy subjects |
| URI | https://www.proquest.com/docview/1710212253 |
| Volume | 4 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nj9MwELXKcuGCgAWxfGmQEAd2U7WJ47Tclo9lWQkudKW9RbbjrFqVZJUmh3LgB_Gv-CfM2E6aLixiuaRV6rpN5sXzPH4zZuyFnHLFkywMeMhlwEWEz1w25kFuxCjikdZJTrnDnz6L41N-chafDQY_e6qlplZD_e2PeSX_Y1U8h3alLNlrWLbrFE_ge7QvHtHCePwnGx8hdyapT0f7FIXjdFOhA6r3Fw0OAl5bjpNtZarKlnf66BMjC9qhYU0ar3JppeVev0V3nWLwpKdzn8417TSNcKGE5VUr-MT29UVFaTFo5vPlWludfeVEt7YWiUuyXO-vGkXhntUVTJh8qw9J5mWZdSx_Rqv4b0RVudfC-FIA87runAlFtxtSD9gAP86k8bJOhh09L9vt0T_Ijd75CwUMXarSO1P5asU-8jEOOw1dO1gnsUB4-RCmH815D7S8NzInvplz8omrZv6b_3ChjMVwkdvyrqGt6up_c6tW9yUf2ikbW9HcIsUuUuoiHcUkHLzBboYJ0jsccoffOxWSoOmbzdn1l9IuvFsJ4qV_sU2dtpmDpUOzO-y2tx4cOlDeZQNT3GO7h4Wsy69reAlWWWyXbHbZjy2cQplDH6dgcQqEU-hw-hocSgHbb1AKPZQegMcotBiFHkYPAHEJfYRCi1BoEQrzAjxCoUXofXZ69H729jjwe4QEOkwmdTDlhstEiSymyotSqUybTE84ZYSPpIyUmuhMKsEzKXMRSSGzOMQpgRlpZcbTPHrAdoqyMA8ZGGSvWhhBmQRcGT4RJhTIhxW6LJ4JscdG7e1PtS-gT_u4LNMrjb7HXnVfuXDVY_7W-Hlr0xTHeFq4k4Upm1U6pmnAGD1v9Og6HT5mtzaPzRO2U1eNeYoUulbPLAh_Abwo0aM |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fortification+of+blackcurrant+juice+with+crowberry%3A+Impact+on+polyphenol+composition%2C+urinary+phenolic+metabolites%2C+and+postprandial+glycemic+response+in+healthy+subjects&rft.jtitle=Journal+of+functional+foods&rft.au=T%C3%B6rr%C3%B6nen%2C+Riitta&rft.au=McDougall%2C+Gordon+J.&rft.au=Dobson%2C+Gary&rft.au=Stewart%2C+Derek&rft.date=2012-10-01&rft.issn=1756-4646&rft.volume=4&rft.issue=4&rft.spage=746&rft.epage=756&rft_id=info:doi/10.1016%2Fj.jff.2012.05.001&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_jff_2012_05_001 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-4646&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-4646&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-4646&client=summon |