Expression of Survivin, CDK4, Ki-67 and Clinical Significance in Pediatric Acute Leukemia

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 26; no. 5; pp. 552 - 554
• Main Author: 张柳清 刘静 林汉华 胡群 刘爱国 胡迎
• Format: Journal Article
• Language: English
• Published: China Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 2006
• Subjects: Adolescent; Apoptosis - physiology; Cell Proliferation; Child; Child, Preschool; Cyclin-Dependent Kinase 4 - metabolism; Female; Humans; Infant; Inhibitor of Apoptosis Proteins - metabolism; Ki-67 Antigen - metabolism; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Acute - pathology; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology; 基因表达; 急性白血病; Ki-67; Survivin; immunohistochemistry; CDK4; acute leukemia
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-006-0517-4

The expression of Survivin, CDK4 and Ki-67 and the clinical significance in pediatric acute leukemia （AL） were investigated. The expression of Survivin, CDK4 and Ki-67 proteins was detected by using immunohistochemical assay in 37 children with AL and l0 children with normal bone marrow as controls. The positive expression rate of Survivin, CDK4 and Ki-67 was 45.9 %, 56.8 %, and 40.5 % respectively in 37 AL children, which was significantly higher than in control group accordingly （P〈0.05）. The expression of Survivin was positively correlated with CDK4 （P=0.007） and Ki-67 （P=0.008）. In conclusion, all Survivin, CDK4 and Ki-67 proteins are over-expressed in pediatric AL and involved in the modulation of apoptosis and proliferation in pediatric AL.