EVALUATION OF THE FUROSEMIDE TEST USING THE ARI CALORIC STIMULATOR

Both the furosemide test, and the glycerol test have been reported as being effective for detection of endolymphatic hydrops. In the furosemide test, the caloric test is performed first, and then repeated 40 minutes after i.v. injection of furosemide, 20mg. The maximum velocities of each caloric nys...

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Published inNippon Jibi Inkoka Gakkai Kaiho Vol. 98; no. 6; pp. 931 - 936,1073
Main Authors FUKAYA, TAKASHI, HATA, YUKO
Format Journal Article
LanguageEnglish
Published The Oto-Rhino-Laryngological Society of Japan, Inc 1995
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ISSN0030-6622
1883-0854
1883-0854
DOI10.3950/jibiinkoka.98.931

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Abstract Both the furosemide test, and the glycerol test have been reported as being effective for detection of endolymphatic hydrops. In the furosemide test, the caloric test is performed first, and then repeated 40 minutes after i.v. injection of furosemide, 20mg. The maximum velocities of each caloric nystagmus are compared, so the caloric stimulus conditions must be constant. In the original method, the caloric test is performed by irrigation with 50ml of water at 30°C or 44°C for 20 seconds. Since it is difficult to accurately maintain the water temperature at a constant level, however, we use the air caloric stimulator NCA-105 (ICS) for the furosemide test. By using this stimulator, we can always perform the caloric test under the same conditions. The conditions of air irrigation in 28 normal subjects were set at 37±11°C, 61/min., and 60 seconds. These conditions were confirmed in other normal subjects to fairly well correspond to water irrigation (30°C or 44°C, 50ml, 20 seconds). Next we reassessed the furosemide test by using the air caloric stimulator in normal subjects. As a result. positive effects were observed in 7.4% of the normal subjects. This finding was similar to that reported in the literature (Futaki et al., 1971). The air caloric test is considered to be a more useful examination than the water caloric test because it is less unpleasant for the subject and easily provides the same conditions before and after furosemide administration.
AbstractList Both the furosemide test, and the glycerol test have been reported as being effective for detection of endolymphatic hydrops. In the furosemide test, the caloric test is performed first, and then repeated 40 minutes after i.v. injection of furosemide, 20mg. The maximum velocities of each caloric nystagmus are compared, so the caloric stimulus conditions must be constant. In the original method, the caloric test is performed by irrigation with 50ml of water at 30°C or 44°C for 20 seconds. Since it is difficult to accurately maintain the water temperature at a constant level, however, we use the air caloric stimulator NCA-105 (ICS) for the furosemide test. By using this stimulator, we can always perform the caloric test under the same conditions. The conditions of air irrigation in 28 normal subjects were set at 37±11°C, 61/min., and 60 seconds. These conditions were confirmed in other normal subjects to fairly well correspond to water irrigation (30°C or 44°C, 50ml, 20 seconds). Next we reassessed the furosemide test by using the air caloric stimulator in normal subjects. As a result. positive effects were observed in 7.4% of the normal subjects. This finding was similar to that reported in the literature (Futaki et al., 1971). The air caloric test is considered to be a more useful examination than the water caloric test because it is less unpleasant for the subject and easily provides the same conditions before and after furosemide administration.
Author FUKAYA, TAKASHI
HATA, YUKO
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References 9) Futaki T, Kitahara M, Morimoto M: The Furosemide test for Ménière's disease. Acta Otolaryngol 79: 419-424, 1975.
1) 二木隆, 北原正章: Frosemide (Lasix) Test. -メニエール病に対する新検査法-. 耳鼻臨床64: 373-389, 1971.
5) 角田玲子, 辺土名仁, 小松崎篤, 畑裕子: 外耳道温度と温度眼振検査の検討: 日常診療における冷温交互試験の問題点. 日耳鼻96: 1933-1939, 1993.
2) Klockhoff I, Lindblom U: Endolymphatic hydrops revealed by Glycerol test. Acta Otolaryngol 61: 459-462, 1966.
11) Matunaga T, Okumura S, Naito T: A new method of detecting endolynphatic hydorops in the inner ear of guinea pigs. -A Frosemide Test-. Medical Journal of Osaka University 29: 169-179, 1978.
12) Futaki T, Kitahara M, Morimoto M: A comparison of the Furosemide and Glycerol tests for Ménière's disease. Acta Otolaryngol 83: 272-278, 1977.
7) 竹田泰三, 北原正章: Air Caloric Test. 耳鼻臨床70: 115-117, 1977.
8) Coats AC, Hebert F, Atwood GR: The Air Caloric Test. A Parametric Study. Arch. Otolaryngol 102: 353-354, 1976.
10) van Deelen GW, Huizing EH: Use of a Diuretic (Dyazide) in the treatment of Ménière's disease. A double-blind cross-over placebo-controlled study. ORL 48: 287-292, 1986.
3) Klockhoff I, Lindblom U: Glycerol test in Ménière disease. Acta Otolaryngol 224: 449-457, 1967.
6) Capps MJ, Preciado MC, Paparella MM: Evaluation of the air caloric test as a routine examination procedure. Laryngoscope 83: 1013-1021, 1973.
4) 山崎晴子, 水越鉄理, 石川和光, 渡辺行雄: Air Caloric Test (判定基準を中心に). 日耳鼻 80: 814-818, 1977.
References_xml – reference: 4) 山崎晴子, 水越鉄理, 石川和光, 渡辺行雄: Air Caloric Test (判定基準を中心に). 日耳鼻 80: 814-818, 1977.
– reference: 7) 竹田泰三, 北原正章: Air Caloric Test. 耳鼻臨床70: 115-117, 1977.
– reference: 6) Capps MJ, Preciado MC, Paparella MM: Evaluation of the air caloric test as a routine examination procedure. Laryngoscope 83: 1013-1021, 1973.
– reference: 1) 二木隆, 北原正章: Frosemide (Lasix) Test. -メニエール病に対する新検査法-. 耳鼻臨床64: 373-389, 1971.
– reference: 11) Matunaga T, Okumura S, Naito T: A new method of detecting endolynphatic hydorops in the inner ear of guinea pigs. -A Frosemide Test-. Medical Journal of Osaka University 29: 169-179, 1978.
– reference: 3) Klockhoff I, Lindblom U: Glycerol test in Ménière disease. Acta Otolaryngol 224: 449-457, 1967.
– reference: 12) Futaki T, Kitahara M, Morimoto M: A comparison of the Furosemide and Glycerol tests for Ménière's disease. Acta Otolaryngol 83: 272-278, 1977.
– reference: 10) van Deelen GW, Huizing EH: Use of a Diuretic (Dyazide) in the treatment of Ménière's disease. A double-blind cross-over placebo-controlled study. ORL 48: 287-292, 1986.
– reference: 8) Coats AC, Hebert F, Atwood GR: The Air Caloric Test. A Parametric Study. Arch. Otolaryngol 102: 353-354, 1976.
– reference: 9) Futaki T, Kitahara M, Morimoto M: The Furosemide test for Ménière's disease. Acta Otolaryngol 79: 419-424, 1975.
– reference: 2) Klockhoff I, Lindblom U: Endolymphatic hydrops revealed by Glycerol test. Acta Otolaryngol 61: 459-462, 1966.
– reference: 5) 角田玲子, 辺土名仁, 小松崎篤, 畑裕子: 外耳道温度と温度眼振検査の検討: 日常診療における冷温交互試験の問題点. 日耳鼻96: 1933-1939, 1993.
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