Coenzyme Q10 as a potent compound that inhibits Cdt1–geminin interaction - Mizushina, Yoshiyuki; Takeuchi, Toshifumi; Takakusagi, Yoichi; Yonezawa, Yuko; Mizuno, Takeshi; Yanagi, Ken-ichiro; Imamoto, Naoko; Sugawara, Fumio; Sakaguchi, Kengo; Yoshida, Hiromi; Fujita, Masatoshi (Biochimica et biophysica acta, 2008)
Keywords: Animals; Cdt1; Cdt1–geminin complex; Cell Cycle Proteins - antagonists & inhibitors; Cell Cycle Proteins - chemistry; Cell Cycle Proteins - metabolism; Cell Proliferation - drug effects; Coenzyme Q10; Coenzymes - pharmacology; Computer Simulation; Docking simulation; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay - methods; Geminin; Humans; Interaction interface; Mice; Models, Chemical; Protein Conformation; The binding inhibitor; Tumor Cells, Cultured; Ubiquinone - analogs & derivatives; Ubiquinone - pharmacology; PBS; ORC; o-PD; Cdt1; RT; Docking simulation; DMSO; HRP; pre-RC; CoQn; GST; Cdt1–geminin complex; Cdk; The binding inhibitor; APC/C; BSA; Interaction interface; His; Coenzyme Q10; MCM; NP-40; Geminin