Induction of 8-azaguanine- and ouabain-resistant mutants by cyclophosphamide and 1-(pyridyl-3)-3,3-dimethyltriazene in Chinese hamster cells cultured in diffusion chambers in mice
A host-mediated assay is described for induction of 8-azaguanine-resistant (azg r) and ouabain-resistant (oua rr) mutants in Chinese hamster V79 cells cultured in diffusion chambers (DC) in C3H mice. Injection of the hosts with the indirect mutagen/carcinogen cyclophosphamide (CPP) or 1-(pyridyl-3)-...
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| Published in | Mutation Research/Environmental Mutagenesis and Related Subjects Vol. 64; no. 4; pp. 259 - 267 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.08.1979
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0165-1161 0027-5107 |
| DOI | 10.1016/0165-1161(79)90095-5 |
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| Abstract | A host-mediated assay is described for induction of 8-azaguanine-resistant (azg
r) and ouabain-resistant (oua
rr) mutants in Chinese hamster V79 cells cultured in diffusion chambers (DC) in C3H mice. Injection of the hosts with the indirect mutagen/carcinogen cyclophosphamide (CPP) or 1-(pyridyl-3)-3,3-dimethyltriazene (PyDT) caused a dose-dependent increase in mutation frequency at the loci of azg
r and oua
r in the V79 target cells. Plating efficiency of V79 cells in DC in mice was decreased depending upon the dose of CPP or PyDT given to the hosts. In addition, the relationship between expression time and mutation frequency was examined and discussed. The data support the use of this system as an effective screening procedure for suspected environmental mutagens or carcinogens, especially those that need to be metabolically activated in vivo. |
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| AbstractList | A host-mediated assay is described for induction of 8-azaguanine-resistant (azgr) and ouabain-resistant (ouar) mutants in Chinese hamster V79 cells cultured in diffusion chambers (DC) in C3H mice. Injection of the hosts with the indirect mutagen/carcinogen cyclophosphamide (CPP) or 1-(pyridyl-3)-3,3-dimethyltriazene (PyDT) caused a dose-dependent increase in mutation frequency at the loci of azgr and ouar in the V79 target cells. Plating efficiency of V79 cells in DC in mice was decreased depending upon the dose of CPP or PyDT given to the hosts. In addition, the relationship between expression time and mutation frequency was examined and discussed. The data support the use of this system as an effective screening procedure for suspected environmental mutagens or carcinogens, especially those that need to be metabolically activated in vivo. A host-mediated assay is described for induction of 8-azaguanine-resistant (azg r) and ouabain-resistant (oua rr) mutants in Chinese hamster V79 cells cultured in diffusion chambers (DC) in C3H mice. Injection of the hosts with the indirect mutagen/carcinogen cyclophosphamide (CPP) or 1-(pyridyl-3)-3,3-dimethyltriazene (PyDT) caused a dose-dependent increase in mutation frequency at the loci of azg r and oua r in the V79 target cells. Plating efficiency of V79 cells in DC in mice was decreased depending upon the dose of CPP or PyDT given to the hosts. In addition, the relationship between expression time and mutation frequency was examined and discussed. The data support the use of this system as an effective screening procedure for suspected environmental mutagens or carcinogens, especially those that need to be metabolically activated in vivo. |
| Author | Sirianni, S.R. Huang, C.C. Furukawa, M. |
| Author_xml | – sequence: 1 givenname: S.R. surname: Sirianni fullname: Sirianni, S.R. organization: Department of Biology, Niagara University, Niagara Falls, NY 14109 U.S.A – sequence: 2 givenname: M. surname: Furukawa fullname: Furukawa, M. organization: Department of Experimental Biology, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, NY 14263, USA – sequence: 3 givenname: C.C. surname: Huang fullname: Huang, C.C. organization: Department of Experimental Biology, Roswell Park Memorial Institute, 666 Elm Street, Buffalo, NY 14263, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/481447$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0027-5107(73)90114-0 10.1016/0027-5107(71)90057-1 10.1007/BF00311275 10.3109/03602537408993740 10.1016/0013-9351(77)90103-7 10.1016/0027-5107(77)90047-1 10.1016/0165-1110(76)90005-1 10.1016/0027-5107(71)90114-X 10.1007/BF00343275 10.1016/0165-1161(73)90010-1 10.1016/0014-4827(78)90191-X 10.1002/ijc.2910130308 10.1016/0027-5107(75)90198-0 10.1016/0027-5107(72)90161-3 10.1016/0027-5107(78)90273-7 10.1016/0027-5107(77)90136-1 10.1016/0027-5107(77)90048-3 10.1016/0027-5107(75)90202-X 10.1016/0027-5107(75)90181-5 10.1016/0027-5107(77)90120-8 |
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| Keywords | PDT CPP SCE b.w PyNDT azg r DC oua r PyDT |
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Issue No. 6 year: 1973 ident: 10.1016/0165-1161(79)90095-5_BIB26 article-title: Comparison of the genetic activity of cyclophosphamine, ifosfamide and trofosfamide in host-medicated assay with the gene conversion system of yeast publication-title: Environ. Health Perspect. – volume: 70 start-page: 2281 year: 1973 ident: 10.1016/0165-1161(79)90095-5_BIB1 article-title: Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection – volume: 158 start-page: 269 year: 1978 ident: 10.1016/0165-1161(79)90095-5_BIB27 article-title: Sister chromatid exchange induced by promutagens/carcinogens in Chinese hamster cells cultured in diffusion chambers in mice – volume: Vol. 2 start-page: 535 year: 1971 ident: 10.1016/0165-1161(79)90095-5_BIB6 article-title: Specific locus mutation in mice – volume: 61 start-page: 1306 year: 1968 ident: 10.1016/0165-1161(79)90095-5_BIB7 article-title: Mammalian cell genetics, II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro – volume: 45 start-page: 103 year: 1977 ident: 10.1016/0165-1161(79)90095-5_BIB23 article-title: A quantitative assay of mutation induction at the hypoxanthine-guanine phosphoribosyl transferase locus in Chinese hamster ovary cells (CHO/HGPRT system): Utilization with a variety of mutagenic agents publication-title: Mutation Res. doi: 10.1016/0027-5107(77)90048-3 – volume: 33 start-page: 261 year: 1975 ident: 10.1016/0165-1161(79)90095-5_BIB3 article-title: A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells publication-title: Mutation Res. doi: 10.1016/0027-5107(75)90202-X – volume: 29 start-page: 285 year: 1975 ident: 10.1016/0165-1161(79)90095-5_BIB15 article-title: Correlation between mutagenicity and carcinogenicity: Mammalian cell transformation and cell-mediated mutagenesis by carcinogenic hydrocarbons publication-title: Mutation Res. doi: 10.1016/0027-5107(75)90181-5 – volume: 153 start-page: 536 year: 1976 ident: 10.1016/0165-1161(79)90095-5_BIB10 article-title: Enhanced effect of cyclophosphamide on Burkitt lymphoma cell lines in vivo – volume: 44 start-page: 119 year: 1977 ident: 10.1016/0165-1161(79)90095-5_BIB14 article-title: Dilution of hypoxanthine-guanine phosphoribosyl transferase and other factors affecting the frequency of 6-thioguanine resistance in Chinese hamster lung cells publication-title: Mutation Res. doi: 10.1016/0027-5107(77)90120-8 |
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| Snippet | A host-mediated assay is described for induction of 8-azaguanine-resistant (azg
r) and ouabain-resistant (oua
rr) mutants in Chinese hamster V79 cells cultured... A host-mediated assay is described for induction of 8-azaguanine-resistant (azgr) and ouabain-resistant (ouar) mutants in Chinese hamster V79 cells cultured in... |
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| SubjectTerms | Animals Azaguanine - pharmacology Cell Line Cricetinae Cyclophosphamide - pharmacology Dose-Response Relationship, Drug Drug Evaluation, Preclinical - methods Drug Resistance Micropore Filters Mutagens Ouabain - pharmacology Phenotype Pyridines - pharmacology Triazenes - pharmacology |
| Title | Induction of 8-azaguanine- and ouabain-resistant mutants by cyclophosphamide and 1-(pyridyl-3)-3,3-dimethyltriazene in Chinese hamster cells cultured in diffusion chambers in mice |
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