Incompatibility of Clindamycin Palmitate Hydrochloride Dry Syrup in Internal Solutions
Incompatibility of clindamycin palmitate hydrochloride dry syrup (CLDM-P·EHCl-DS) in various internal solutions was studied. Above pH 4.1, hydrochloride was dissociated from clindamycin palmitate, and a white turbidity was produced. CLDM-P·HCl-DS was dissolved in 14 different solutions, where 10 gav...
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Published in | Byōin yakugaku Vol. 7; no. 3; pp. 192 - 195 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Japanese |
Published |
Japanese Society of Pharmaceutical Health Care and Sciences
1981
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Online Access | Get full text |
ISSN | 0389-9098 2185-9477 |
DOI | 10.5649/jjphcs1975.7.192 |
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Abstract | Incompatibility of clindamycin palmitate hydrochloride dry syrup (CLDM-P·EHCl-DS) in various internal solutions was studied. Above pH 4.1, hydrochloride was dissociated from clindamycin palmitate, and a white turbidity was produced. CLDM-P·HCl-DS was dissolved in 14 different solutions, where 10 gave a change in appearance. When stored below 5°, CLDM-P·EHCl-DS solution often turned to a white gel. |
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AbstractList | Incompatibility of clindamycin palmitate hydrochloride dry syrup (CLDM-P·EHCl-DS) in various internal solutions was studied. Above pH 4.1, hydrochloride was dissociated from clindamycin palmitate, and a white turbidity was produced. CLDM-P·HCl-DS was dissolved in 14 different solutions, where 10 gave a change in appearance. When stored below 5°, CLDM-P·EHCl-DS solution often turned to a white gel. |
Author | MIZUNO, NOBUYASU SHINKUMA, DENJI NODA, MASAYO KITAJIMA, KEIKO YAMANAKA, YOU HAMAGUCHI, TUNEO |
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References | 4) 神代昭, 川邑年四郎, 北沢式文, 清水龍夫, 中島繁美, 二宮英, 福地坦: 薬剤学別冊付録, 38 (1), 24 (1978). 5) 田辺登: 薬局, 26,565 (1975). 3) 南部春生, 村山隆志, 児玉進, 滝本昌俊, 末広忠雄: J. Antibiotics., 26,334 (1973 6) 厚生省薬務局監修;“日本抗生物質医薬品基準解説”, 薬業時報社, 東京, 1978. p.497 藤井良和, 紺野昌俊, 生方公子, 佐久間昭: J. Antibiotics., 26,545 (1973). 1) 石山俊次, 中山一誠, 岩本英男, 岩井重富, 鷹取睦美, 川辺隆道, 坂田育弘, 夏野窓, 秋枝洋三: J. Antibiotics., 26,381 (1973). 2) 小野尚子, 大槻雅子, 中沢昭三: J. Antibiotics., 26,321 (1973). |
References_xml | – reference: 4) 神代昭, 川邑年四郎, 北沢式文, 清水龍夫, 中島繁美, 二宮英, 福地坦: 薬剤学別冊付録, 38 (1), 24 (1978). – reference: 5) 田辺登: 薬局, 26,565 (1975). – reference: 3) 南部春生, 村山隆志, 児玉進, 滝本昌俊, 末広忠雄: J. Antibiotics., 26,334 (1973); – reference: 6) 厚生省薬務局監修;“日本抗生物質医薬品基準解説”, 薬業時報社, 東京, 1978. p.497 – reference: 2) 小野尚子, 大槻雅子, 中沢昭三: J. Antibiotics., 26,321 (1973). – reference: 1) 石山俊次, 中山一誠, 岩本英男, 岩井重富, 鷹取睦美, 川辺隆道, 坂田育弘, 夏野窓, 秋枝洋三: J. Antibiotics., 26,381 (1973). – reference: 藤井良和, 紺野昌俊, 生方公子, 佐久間昭: J. Antibiotics., 26,545 (1973). |
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Title | Incompatibility of Clindamycin Palmitate Hydrochloride Dry Syrup in Internal Solutions |
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