Incompatibility of Clindamycin Palmitate Hydrochloride Dry Syrup in Internal Solutions

Incompatibility of clindamycin palmitate hydrochloride dry syrup (CLDM-P·EHCl-DS) in various internal solutions was studied. Above pH 4.1, hydrochloride was dissociated from clindamycin palmitate, and a white turbidity was produced. CLDM-P·HCl-DS was dissolved in 14 different solutions, where 10 gav...

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Published inByōin yakugaku Vol. 7; no. 3; pp. 192 - 195
Main Authors YAMANAKA, YOU, NODA, MASAYO, SHINKUMA, DENJI, MIZUNO, NOBUYASU, HAMAGUCHI, TUNEO, KITAJIMA, KEIKO
Format Journal Article
LanguageJapanese
Published Japanese Society of Pharmaceutical Health Care and Sciences 1981
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ISSN0389-9098
2185-9477
DOI10.5649/jjphcs1975.7.192

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Summary:Incompatibility of clindamycin palmitate hydrochloride dry syrup (CLDM-P·EHCl-DS) in various internal solutions was studied. Above pH 4.1, hydrochloride was dissociated from clindamycin palmitate, and a white turbidity was produced. CLDM-P·HCl-DS was dissolved in 14 different solutions, where 10 gave a change in appearance. When stored below 5°, CLDM-P·EHCl-DS solution often turned to a white gel.
ISSN:0389-9098
2185-9477
DOI:10.5649/jjphcs1975.7.192