Severe Acute Respiratory Syndrome Coronavirus 2 Spreads to Lymph Nodes and Strongly Expands CD4+ Effector Memory RA Cells in a Patient With Mild Coronavirus Disease 2019

Abstract A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mi...

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Published inClinical infectious diseases Vol. 73; no. 11; pp. e3970 - e3973
Main Authors Roldán-Santiago, Ernesto, Benito-Berlinches, Amparo, Martínez-García, Laura, Quereda, Carmen, Rodríguez-Martín, Eulalia, Pérez-Elías, Pilar, López-Pintor, Jose María, Walo-Delgado, Paulette Esperanza, Moreno-Zamora, Ana, Fernández-Velasco, Jose Ignacio, García-Abellás, Patricia, Ballester-González, Rubén, Villar, Luisa M, Pérez-Elías, María Jesús
Format Journal Article
LanguageEnglish
Published US Oxford University Press 06.12.2021
Subjects
SARS-CoV-2
CD4
cells
T
coinfection
lymph node
Online AccessGet full text
ISSN1058-4838
1537-6591
1537-6591
DOI10.1093/cid/ciaa1422

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Abstract Abstract A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.
AbstractList A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.
Abstract A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.
A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine needle aspiration, and demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in lymph nodes even in mild disease along with a strong expansion of terminally differentiated effector memory CD4+ T cells, a cell population that is practically absent in lymph nodes.
Author Ballester-González, Rubén
Walo-Delgado, Paulette Esperanza
Villar, Luisa M
Quereda, Carmen
López-Pintor, Jose María
Martínez-García, Laura
Pérez-Elías, Pilar
Pérez-Elías, María Jesús
Fernández-Velasco, Jose Ignacio
Benito-Berlinches, Amparo
Rodríguez-Martín, Eulalia
García-Abellás, Patricia
Moreno-Zamora, Ana
Roldán-Santiago, Ernesto
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  surname: Roldán-Santiago
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  organization: Immunology, Hospital Ramón y Cajal Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
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  surname: Benito-Berlinches
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  givenname: Laura
  surname: Martínez-García
  fullname: Martínez-García, Laura
  organization: Microbiology, Hospital Ramón y Cajal IRYCIS, Madrid, Spain
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  fullname: Quereda, Carmen
  organization: Infectious Diseases, Hospital Ramón y Cajal IRYCIS, Madrid, Spain
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  givenname: Jose María
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  organization: Microbiology, Hospital Ramón y Cajal IRYCIS, Madrid, Spain
– sequence: 8
  givenname: Paulette Esperanza
  surname: Walo-Delgado
  fullname: Walo-Delgado, Paulette Esperanza
  organization: Immunology, Hospital Ramón y Cajal Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
– sequence: 9
  givenname: Ana
  surname: Moreno-Zamora
  fullname: Moreno-Zamora, Ana
  organization: Infectious Diseases, Hospital Ramón y Cajal IRYCIS, Madrid, Spain
– sequence: 10
  givenname: Jose Ignacio
  surname: Fernández-Velasco
  fullname: Fernández-Velasco, Jose Ignacio
  organization: Immunology, Hospital Ramón y Cajal Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain
– sequence: 11
  givenname: Patricia
  surname: García-Abellás
  fullname: García-Abellás, Patricia
  organization: Pathology, Hospital Ramón y Cajal IRYCIS, Madrid, Spain
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  givenname: Rubén
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  givenname: María Jesús
  orcidid: 0000-0001-5700-5257
  surname: Pérez-Elías
  fullname: Pérez-Elías, María Jesús
  email: mjperez90@gmail.com
  organization: Infectious Diseases, Hospital Ramón y Cajal IRYCIS, Madrid, Spain
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Cites_doi 10.1038/s41467-017-01728-5
10.1038/s41591-020-0819-2
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ContentType Journal Article
Copyright The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020
The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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– notice: The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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coinfection
lymph node
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Snippet Abstract A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed...
A woman with mild coronavirus disease 2019 developed cervical adenopathy, being diagnosed of Epstein-Barr virus infectious mononucleosis. We performed fine...
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