Magnifying i-scan Imaging for Endoscopic Diagnosis of Helicobacter pylori Infection: A Prospective Study

• Published in: Journal of digestive endoscopy Vol. 11; no. 2; pp. 112 - 117
• Main Authors: Balekuduru, Avinash Bhat, Rau, Aarathi, Gouri, Mangala, Shetty, Athish, Subbaraj, Satyaprakash Bonthala
• Format: Journal Article
• Language: English
• Published: A-12, Second Floor, Sector -2, NOIDA -201301, India Thieme Medical and Scientific Publishers Private Ltd 01.06.2020; Thieme Medical and Scientific Publishers Pvt. Ltd
• Subjects: helicobacter pylori gastritis; i-scan; magnifying white light endoscopy; Original Article; i-scan; gastritis; magnifying white light endoscopy
• ISSN: 0976-5042; 0976-5050
• DOI: 10.1055/s-0040-1709341

Abstract Background  DEFINA (EPK 3000) plus (with i-scan) is a digital chromoendoscopy. It uses surface/tone/contrast enhancement for detection, demarcation, and characterization of lesions. The aim of this study was to compare the usefulness of i-scan and conventional magnification white light endoscopy (M-WLE) for diagnosing Helicobacter pylori (Hp) infection in stomach. Patients and Methods  Subjects undergoing evaluation for functional dyspepsia were prospectively enrolled at Ramaiah Medical College and Hospitals, Bangalore from November 2018 to February 2019. In total, 68 participants underwent gastroscopy with standard M-WLE followed by i-scan. Two biopsies from greater curve at 3 cm from the angulus were collected for histology. Successful diagnosis of Hp using imaging modality with M-WLE and i-scan were compared with histology. Results  A total of 68 (36 men and 32 women) patients with a mean age of 47 ± 13 years (range 18–75 years) were enrolled in our study. The prevalence of Hp on the biopsies was 41%; 64% of the patients used proton pump inhibitors, 20% were current smokers; 25% of the patients were consuming alcohol. The sensitivity: 96.4%; specificity: 95%; accuracy: 95.5% of i-scan in diagnosis of Hp gastritis is better than the sensitivity: 50%; specificity: 50%; accuracy: 50% with M-WLE. Conclusion  In conclusion, the diagnostic ability of i-scan (95%) for predicting Hp status is acceptable as compared with M-WLE (50%) for accurate diagnosis. The results suggest that i-scan improves endoscopic diagnostic accuracy of Hp infection compared with M-WLE.