Preparation and Evaluation of Microcapsule Containing Volatile Oil of Herba Schizonepetae by Emulsion Solvent Diffusion Method
Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results...
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| Published in | Transactions of Tianjin University Vol. 20; no. 2; pp. 103 - 111 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Heidelberg
Tianjin University
01.04.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-4982 1995-8196 |
| DOI | 10.1007/s12209-014-2182-1 |
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| Abstract | Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results illustrated that the ratio of ethyl cellulose（EC） to VOHS influenced the property of VOHS microcapsule significantly.GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation.The microcapsules prepared with optimum condition had good fluidity,and the holes on the surface of the microcapsules contributed to the release of VOHS.The particles of the microcapsule conformed to a normal distribution with the diameter of 45—220 μm.In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate,pulegone in VOHS microcapsule showed a certain degree of slow release.Compared with β-cyclodextrin method,the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading.It was beneficial to reduce the dose of Chinese medicines containing volatile oils. |
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| AbstractList | Microcapsules of volatile oil containing Herba Schizonepetae (VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients. Orthogonal assay was applied to optimize the preparation condition of microcapsulation, and the results illustrated that the ratio of ethyl cellulose (EC) to VOHS influenced the property of VOHS microcapsule significantly. GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation. The microcapsules prepared with optimum condition had good fluidity, and the holes on the surface of the microcapsules contributed to the release of VOHS. The particles of the microcapsule conformed to a normal distribution with the diameter of 45-220 μm. In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate, pulegone in VOHS microcapsule showed a certain degree of slow release. Compared withβ-cyclodextrin method, the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading. It was beneficial to reduce the dose of Chinese medicines containing volatile oils. Microcapsules of volatile oil containing Herba Schizonepetae (VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients. Orthogonal assay was applied to optimize the preparation condition of microcapsulation, and the results illustrated that the ratio of ethyl cellulose (EC) to VOHS influenced the property of VOHS microcapsule significantly. GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation. The microcapsules prepared with optimum condition had good fluidity, and the holes on the surface of the microcapsules contributed to the release of VOHS. The particles of the microcapsule conformed to a normal distribution with the diameter of 45–220 μm. In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate, pulegone in VOHS microcapsule showed a certain degree of slow release. Compared with β -cyclodextrin method, the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading. It was beneficial to reduce the dose of Chinese medicines containing volatile oils. Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results illustrated that the ratio of ethyl cellulose（EC） to VOHS influenced the property of VOHS microcapsule significantly.GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation.The microcapsules prepared with optimum condition had good fluidity,and the holes on the surface of the microcapsules contributed to the release of VOHS.The particles of the microcapsule conformed to a normal distribution with the diameter of 45—220 μm.In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate,pulegone in VOHS microcapsule showed a certain degree of slow release.Compared with β-cyclodextrin method,the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading.It was beneficial to reduce the dose of Chinese medicines containing volatile oils. |
| Author | 张立国 欧阳霄雯 倪力军 史万忠 |
| AuthorAffiliation | School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200025, China |
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| CitedBy_id | crossref_primary_10_1016_j_jep_2015_12_052 crossref_primary_10_1080_02652048_2020_1749320 crossref_primary_10_1016_j_jep_2014_07_011 |
| Cites_doi | 10.3109/02652048409031537 10.1002/jssc.200800574 10.1016/j.jconrel.2004.01.005 10.1016/S0169-409X(97)00048-3 10.1016/j.fct.2007.09.106 10.1080/02652040701500632 10.3993/jfbi03200907 10.1248/cpb.31.4476 10.1016/j.seppur.2010.12.012 10.1016/j.fct.2008.11.006 10.3109/03639049109043848 10.1016/S0378-5173(00)00686-4 |
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| Copyright | Tianjin University and Springer-Verlag Berlin Heidelberg 2014 Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Notes | Zhang Liguo;Ouyang Xiaowen;Ni Lijun;Shi Wanzhong;School of Chemistry and Molecular Engineering,East China University of Science and Technology;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Herba Schizonepetae； volatile oils； microencapsulation 12-1248/T Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce the amount of pharmaceutical excipients.Orthogonal assay was applied to optimize the preparation condition of microcapsulation,and the results illustrated that the ratio of ethyl cellulose（EC） to VOHS influenced the property of VOHS microcapsule significantly.GC-MS analysis indicated that some volatile components with low concentration in VOHS were lost after microencapsulation.The microcapsules prepared with optimum condition had good fluidity,and the holes on the surface of the microcapsules contributed to the release of VOHS.The particles of the microcapsule conformed to a normal distribution with the diameter of 45—220 μm.In the simulated intestinal fluid containing 0.2% sodium dodecyl sulfate,pulegone in VOHS microcapsule showed a certain degree of slow release.Compared with β-cyclodextrin method,the microencapsulation used in the present work could reduce the amount of excipients and increase the drug loading.It was beneficial to reduce the dose of Chinese medicines containing volatile oils. |
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| Snippet | Microcapsules of volatile oil containing Herba Schizonepetae（VOHS） were prepared by emulsion solvent diffusion method to improve the drug loading and reduce... Microcapsules of volatile oil containing Herba Schizonepetae (VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce... Microcapsules of volatile oil containing Herba Schizonepetae (VOHS) were prepared by emulsion solvent diffusion method to improve the drug loading and reduce... |
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| Title | Preparation and Evaluation of Microcapsule Containing Volatile Oil of Herba Schizonepetae by Emulsion Solvent Diffusion Method |
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