Allelic Variants Interaction of CLOCK Gene and G-Protein β3 Subunit Gene with Diurnal Preference
The 3111 C T single nucleotide polymorphism (SNP) in the CLOCK gene and the 825C T SNP in the G-protein β3 subunit gene (GNB3) have been reported to influence diurnal preference. This study has attempted to characterize the association between the CLOCK gene and GNB3 polymorphisms and diurnal prefer...
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| Published in | Chronobiology international Vol. 24; no. 4; pp. 589 - 597 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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Informa UK Ltd
01.01.2007
Taylor & Francis |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0742-0528 1525-6073 |
| DOI | 10.1080/07420520701534632 |
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| Abstract | The 3111 C T single nucleotide polymorphism (SNP) in the CLOCK gene and the 825C T SNP in the G-protein β3 subunit gene (GNB3) have been reported to influence diurnal preference. This study has attempted to characterize the association between the CLOCK gene and GNB3 polymorphisms and diurnal preference in healthy Korean college students. All subjects completed the 13-item Composite Scale for Morningness (CSM). The interaction between the 3111 C T SNP in the CLOCK gene and the 825 C T SNP in the GNB3 gene significantly influenced diurnal preference, according to the CSM Performance subscore (F=10.94, p=0.001). However, when the different polymorphisms of the two genes were analyzed independently, no direct correlations with diurnal preference were detected. The CLOCK gene 3111 C T SNP and GNB3 gene 825 C T SNP were found to manifest a gene-gene interaction that affects diurnal preference. |
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| AbstractList | The 3111 C/T single nucleotide polymorphism (SNP) in the CLOCK gene and the 825C/T SNP in the G-protein β3 subunit gene (GNB3) have been reported to influence diurnal preference. This study has attempted to characterize the association between the CLOCK gene and GNB3 polymorphisms and diurnal preference in healthy Korean college students. All subjects completed the 13-item Composite Scale for Morningness (CSM). The interaction between the 3111 C/T SNP in the CLOCK gene and the 825 C/T SNP in the GNB3 gene significantly influenced diurnal preference, according to the CSM Performance subscore (F=10.94, p=0.001). However, when the different polymorphisms of the two genes were analyzed independently, no direct correlations with diurnal preference were detected. The CLOCK gene 3111 C/T SNP and GNB3 gene 825 C/T SNP were found to manifest a gene-gene interaction that affects diurnal preference. |
| Author | Kang, Seung-Gul Paik, Jong-Woo Lee, Heon-Jeong Lim, Se-Won Kim, Leen |
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| Snippet | The 3111 C T single nucleotide polymorphism (SNP) in the CLOCK gene and the 825C T SNP in the G-protein β3 subunit gene (GNB3) have been reported to influence... The 3111 C/T single nucleotide polymorphism (SNP) in the CLOCK gene and the 825C/T SNP in the G-protein β3 subunit gene (GNB3) have been reported to influence... |
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| SubjectTerms | CLOCK gene Diurnal preference Epistasis G-protein β3 subunit gene Morningness-eveningness |
| Title | Allelic Variants Interaction of CLOCK Gene and G-Protein β3 Subunit Gene with Diurnal Preference |
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