Pretreatment with repeated electroacupuncture attenuates transient focal cerebral ischemic injury in rats
Objective To investigate whether pretreatment with repeated electroacupuncture(EA)at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats.Methods Thirty male Sprague-Dawley(SD)rats were randomlydivided into 3 groups(n=10 for each):the control g...
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| Published in | Chinese medical journal Vol. 116; no. 1; pp. 108 - 111 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
China
Department of Anesthesiology, Xijing Hospital of the Fourth Military Medical University, Xi'an 710032, China
2003
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0366-6999 2542-5641 |
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| Abstract | Objective To investigate whether pretreatment with repeated electroacupuncture(EA)at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats.Methods Thirty male Sprague-Dawley(SD)rats were randomlydivided into 3 groups(n=10 for each):the control group consisted of animals receiving no treatment,the isoflurane(ISO)goup had animals that inhaled 1.5?isoflurane for 30 min a day for 5 days,and animals in the EA group received electroacupuncture at the Baihui acupoint for 30 min a day for 5 days under 1.5?isoflurane anesthesia.Twenty-four hours after the last treatment,the middle cerebral artery was occluded with No.3 nylon monofilament for 120 min.The neurological outcomes were evaluated 24 h after reperfusion.The infarct volumes were then assessed using 2?triphenyltetrazolium chloride staining after the neurological outcome evaluation.Results The neurological deficit score(NDS)of the EA group[1(0-2] was lower than that of the ISO group [2(1-3)]and the control group[2(1-4)],P<0.05.The infarct volume of the EA group(38.3±25.4mm^3) was significantly smaller than that of the control group(220.5±66.0mm^3)and the ISO group(168.6±57.6mm^3)24h after reperfusion.Conclusion Electroacupuncture at the Baihui acupoint 30 min a day for 5 days significantly reduces neurological injury induced by transient middle cerebral artery occlusion. |
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| AbstractList | Objective To investigate whether pretreatment with repeated electroacupuncture(EA)at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats.Methods Thirty male Sprague-Dawley(SD)rats were randomlydivided into 3 groups(n=10 for each):the control group consisted of animals receiving no treatment,the isoflurane(ISO)goup had animals that inhaled 1.5?isoflurane for 30 min a day for 5 days,and animals in the EA group received electroacupuncture at the Baihui acupoint for 30 min a day for 5 days under 1.5?isoflurane anesthesia.Twenty-four hours after the last treatment,the middle cerebral artery was occluded with No.3 nylon monofilament for 120 min.The neurological outcomes were evaluated 24 h after reperfusion.The infarct volumes were then assessed using 2?triphenyltetrazolium chloride staining after the neurological outcome evaluation.Results The neurological deficit score(NDS)of the EA group[1(0-2] was lower than that of the ISO group [2(1-3)]and the control group[2(1-4)],P<0.05.The infarct volume of the EA group(38.3±25.4mm^3) was significantly smaller than that of the control group(220.5±66.0mm^3)and the ISO group(168.6±57.6mm^3)24h after reperfusion.Conclusion Electroacupuncture at the Baihui acupoint 30 min a day for 5 days significantly reduces neurological injury induced by transient middle cerebral artery occlusion. To investigate whether pretreatment with repeated electroacupuncture (EA) at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats.OBJECTIVETo investigate whether pretreatment with repeated electroacupuncture (EA) at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats.Thirty male Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=10 for each): the control group consisted of animals receiving no treatment, the isoflurane (ISO) group had animals that inhaled 1.5% isoflurane for 30 min a day for 5 days, and animals in the EA group received electroacupuncture at the Baihui acupoint for 30 min a day for 5 days under 1.5% isoflurane anesthesia. Twenty-four hours after the last treatment, the middle cerebral artery was occluded with No. 3 nylon monofilament for 120 min. The neurological outcomes were evaluated 24 h after reperfusion. The infarct volumes were then assessed using 2% triphenyltetrazolium chloride staining after the neurological outcome evaluation.METHODSThirty male Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=10 for each): the control group consisted of animals receiving no treatment, the isoflurane (ISO) group had animals that inhaled 1.5% isoflurane for 30 min a day for 5 days, and animals in the EA group received electroacupuncture at the Baihui acupoint for 30 min a day for 5 days under 1.5% isoflurane anesthesia. Twenty-four hours after the last treatment, the middle cerebral artery was occluded with No. 3 nylon monofilament for 120 min. The neurological outcomes were evaluated 24 h after reperfusion. The infarct volumes were then assessed using 2% triphenyltetrazolium chloride staining after the neurological outcome evaluation.The neurological deficit score (NDS) of the EA group [1 (0-2)] was lower than that of the ISO group [2 (1-3)] and the control group [2 (1-4)], P < 0.05. The infarct volume of the EA group (38.3 +/- 25.4 mm(3)) was significantly smaller than that of the control group (220.5 +/- 66.0 mm(3)) and the ISO group (168.6 +/- 57.6 mm(3)) 24 h after reperfusion.RESULTSThe neurological deficit score (NDS) of the EA group [1 (0-2)] was lower than that of the ISO group [2 (1-3)] and the control group [2 (1-4)], P < 0.05. The infarct volume of the EA group (38.3 +/- 25.4 mm(3)) was significantly smaller than that of the control group (220.5 +/- 66.0 mm(3)) and the ISO group (168.6 +/- 57.6 mm(3)) 24 h after reperfusion.Electroacupuncture at the Baihui acupoint 30 min a day for 5 days significantly reduces neurological injury induced by transient middle cerebral artery occlusion.CONCLUSIONElectroacupuncture at the Baihui acupoint 30 min a day for 5 days significantly reduces neurological injury induced by transient middle cerebral artery occlusion. R74; Objective To investigate whether pretreatment with repeated electroacupuncture (EA)at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats. Methods Thirty male Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=10 for each): the control group consisted of animals receiving no treatment, the isoflurane (ISO) group had animals that inhaled 1.5% isoflurane for 30 min a day for 5 days, and animals in the EA group received electroacupuncture at the Baihui acupoint for 30 min a day for 5 days under 1.5% isoflurane anesthesia. Twenty-four hours after the last treatment, the middle cerebral artery was occluded with No. 3 nylon monofilament for 120 min. The neurological outcomes were evaluated 24 h after reperfusion. The infarct volumes were then assessed using 2% triphenyltetrazolium chloride staining after the neurological outcome evaluation. Results The neurological deficit score (NDS) of the EA group [1 (0-2)] was lower than that of the ISO group [2 (1-3)] and the control group [2 (1-4)], P<0.05. The infarct volume of the EA group (38.3±25.4 mm3) was significantly smaller than that of the control group (220.5±66.0 mm3) and the ISO group (168.6±57.6 mm3) 24 h after reperfusion. Conclusion Electroacupuncture at the Baihui acupoint 30 min a day for 5 days significantly reduces neurological injury induced by transient middle cerebral artery occlusion. To investigate whether pretreatment with repeated electroacupuncture (EA) at the Baihui acupoint could induce ischemic tolerance against transient focal cerebral ischemic injury in rats. Thirty male Sprague-Dawley (SD) rats were randomly divided into 3 groups (n=10 for each): the control group consisted of animals receiving no treatment, the isoflurane (ISO) group had animals that inhaled 1.5% isoflurane for 30 min a day for 5 days, and animals in the EA group received electroacupuncture at the Baihui acupoint for 30 min a day for 5 days under 1.5% isoflurane anesthesia. Twenty-four hours after the last treatment, the middle cerebral artery was occluded with No. 3 nylon monofilament for 120 min. The neurological outcomes were evaluated 24 h after reperfusion. The infarct volumes were then assessed using 2% triphenyltetrazolium chloride staining after the neurological outcome evaluation. The neurological deficit score (NDS) of the EA group [1 (0-2)] was lower than that of the ISO group [2 (1-3)] and the control group [2 (1-4)], P < 0.05. The infarct volume of the EA group (38.3 +/- 25.4 mm(3)) was significantly smaller than that of the control group (220.5 +/- 66.0 mm(3)) and the ISO group (168.6 +/- 57.6 mm(3)) 24 h after reperfusion. Electroacupuncture at the Baihui acupoint 30 min a day for 5 days significantly reduces neurological injury induced by transient middle cerebral artery occlusion. |
| Author | 熊利泽 路志红 侯立朝 郑恒兴 朱正华 王强 陈绍洋 |
| AuthorAffiliation | DepartmentofAnesthesiology,XijingHospitaloftheFourthMilitaryMedicalUniversity,Xi’an710032,China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12667400$$D View this record in MEDLINE/PubMed |
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| Keywords | ischemic preconditioning cerebral ischemia,focal electroacupuncture |
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| SubjectTerms | Animals Electroacupuncture Ischemic Attack, Transient - therapy Male Rats Rats, Sprague-Dawley 局灶性短暂性脑缺血损伤 百会穴 缺血耐受性 重复电针 预处理 |
| Title | Pretreatment with repeated electroacupuncture attenuates transient focal cerebral ischemic injury in rats |
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